News


Recent web app / tool updates:

September 2024: Added data for ITP cohort 2018

September 2024: Added data for ITP cohort 2019

August 2023: Updated GenomeMUSter: imputed genotype resource

April 2023: Fuji Plot available within GWAS Meta-Analysis tool

April 2023: ITP Cohort 2017 information available in ITP dataset

March 2022: GWAS Meta-analysis tool

March 2022: GenomeMUSter: new imputed genotype resource

January 2022: Highlights :
    • SIP : Measures can be selected as Private or Public within a SIP Project.
    • SIP : Private measures not displayed for Public Released Projects.
    • MPD : Latest CSNA03 Data loaded from LIMS.
    • MPD : Moved latest KOMP data from mpdpreview to phenome.
    • MPD : IPT1: C2016 data imported to phenome.

September 2021: Bug fixes for phenomedoc.jax.org Phenome documentation site.

June 2021: Message added About Ontology descendants on Measure Results page. Automate KOMP data loading.

View earlier news items


April 2021: Production Release of ITP C2015. CSNA data upload.

March 2021 Hotfix: Some measures from Ontologies were not displayed in Measure table. (MP:00080777)

March 2021: Field Length Limitation in Database was removed. MPD single measure, repeated, and multicohort analytics should be enabled (in their current state) for any measure that has 2 strains and up. Exclude informational measures from sample sizes view.

17 Nov 2020: Navigation: the toolbar for phenotype display and analysis is now available directly below the blue table of measures on many pages in the application. Select measure checkboxes then scroll down and apply the desired tool.

17 Nov 2020: New 'Compare Measure Metadata' tool.

14 Sep 2020:   We've released a large data and functionality package: Multisystem phenotyping of KOMP strains and C57BL/6NJ controls. JaxKOMP-EAP (early adult, 1800+ genotypes and 360+ phenotypes) and JaxKOMP-LAP (late adult, 175+ genotypes and 280+ phenotypes). Phenotyping and data collection are ongoing; updates will be done here periodically.

2 July 2020:   We've upgraded our facilities for signing in to MyMPD. Most non-Jax users should be able to use their existing MyMPD credentials but if not you can either register again or contact us for assistance. Jax users must now use the "Continue with Jax Single Sign On" button.

19 Mar 2020:   We have updated the pyLMM tool to omit SNPs with minor allele frequency (MAF) < 0.05. This will therefore reduce the number of SNPs in the analysis but avoid spurious peaks.

21 Oct 2019:   Animal IDs were modified in 50 MPD projects, so that animal IDs are now unique within a project. Original IDs were retained and a qualifier was appended where necessary.

19 Aug 2019:   PyLMM GWAS analyses have been added.

31 May 2019:   Ontology navigation has been added.

31 May 2019:   Some new API endpoints have been added.

11 Mar 2019:   Various new data sets (see list below) and functionality improvements.

30 Jan 2019:   A new visualization is available for DO phenotype measures... here's an example. A new Ratios and Differences View is now available via the phenotype tools page.

27 Nov 2018:   A new Curves Comparison View is now present on measure series views and via the phenotype tools page.

27 Nov 2018:   MPD's individual strain pages link to MGI's new strain pages.

12 Oct 2018:   Data for a number of new compounds has been added to MPD's portal (ITP1) for National Institute on Aging's Interventions Testing Program (effects of various treatments on lifespan and related phenotypes).


07 Aug 2018:   A new Multivariate Outlier Detection tool has been added. Available via the phenotype tools page. See our statistical analysis glossary for more info.

24 July 2018:   Various new data sets (see list below) and functionality improvements.

24 April 2018:   A new updated phenotype tool has been added. From the phenotype tools page click on either the "Strain means table and downloads" or "Find strains by criteria fit" buttons. The tool can be used to view strain means from an arbitrary set of measures in a sortable table, download arbitrary strain means as CSV or JSON, as well as perform criteria fit analysis to find strains that best meet one or more "high", "medium", "low" criteria.

29 December, 2017:   Web app update

This update includes enhancements to phenotype correlations and scatterplot tools, including support for individual animal data points and unadjusted strain means, as well as look and feel updates. We also upgraded our infrastructure to use Python 3.6.


18 September, 2017:   Web app update

Enhanced phenotype tools usage, including ways to deploy several tools together on one page.


7 August, 2017:   Web app update
    • new data sets added and several SNP data sets reinstated
    • new user feedback form (via web page footers)
    • a new way to list phenotype measure sets by study design type (via Menu pulldown)
    • new SNP strains selection feature (when a specific data set is selected)
    • incremental enhancements to data displays and visualizations
    • urls are now https

7 June, 2017:   A completely new version of MPD's web application released

All aspects of our resource have been revisited. All pages have updated navigation patterns and appearance. Some new data visualizations are included; development of new tools, visualizations, and new data sharing capabilities is ongoing.

Regular MPD users will note the following differences that could impact their activities: MPD's customized phenotype categorization has been discontinued in favor of standard ontologies. Individual strain pages now emphasize searching for desired data rather than category listings. Most gene expression functionality has been discontinued. The old app's "shopping cart" has been replaced by "MyMPD". MyMPD can be used in guest mode or by registering. Old shopping cart contents are not automatically brought forward into MyMPD; users with needs in this area should contact us.

Please contact us if we can help with transitionary issues. Our goal is to accommodate user needs during this transition to the extent possible.


Current publication
An article about MPD appears in the Nucleic Acids Research 2023 Database Issue



Recent data set releases / history
• Data changelog

08 / 2024:     ITP1
Interventions Testing Program: Effects of various treatments on lifespan and related phenotypes in genetically heterogeneous mice (UM-HET3)

12 / 2023:     CSNA02
Reward sensitivity, impulse action and choice, and drinking in the dark in Collaborative Cross strains of mice and 8 founder inbred strains

02 / 2023:     Xenakis2
Effects of inorganic arsenic exposure on body composition and type 2 diabetes indicators in Diversity Outbred (DO) male mice

01 / 2023:     Mooney1
Cerebellum and hippocampus acetylcholinesterase activity in males of 20 inbred strains of mice

01 / 2023:     Nadeau3
Diet-induced metabolic syndrome measures in males of C57BL/6J and A/J inbred strains of mice

01 / 2023:     Nadeau4
Diet-induced body weight gain in males of C57BL/6J-Chr6A/J/NaJ chromosome substitution mice along with parental strains

09 / 2022:     Schoonjans1
Changes in bile acid pool size and composition in plasma, feces and liver; body and organ weights; and blood glucose levels in male mice of 34 BXD recombinant inbred strains and two parental strains fed chow or high-fat diet

06 / 2022:     Auwerx2
Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in Collaborative Cross founder strains of mice

04 / 2022:     Bennett4
Diet effects on body composition, plasma chemistry, lipid profile, metabolism, activity, and food intake in females of 22 Collaborative Cross strains of mice

02 / 2022:     CSNA03
Behavioral phenotypes on cocaine self-administration, acute drug response, impulsivity, reward seeking, and circadian dysregulation in Collaborative Cross strains of mice, Diversity Outbred mice, and their 8 founder inbred strains

12 / 2021:     Kumar4
Gait and whole body posture measures in 52 inbred strains of mice and 10 F1 hybrid lines

04 / 2021:     Graham2
SARS-CoV infection in females of 117 F1 hybrid lines of Collaborative Cross strains of mice (CC RIX)

04 / 2021:     Graham3
Baseline T cell immune phenotypes in males of 104 F1 hybrid lines of Collaborative Cross strains of mice (CC RIX) predict virologic and disease control upon SARS-CoV infection

04 / 2021:     Kumar3
Grooming behavior and locomotor activity in 51 inbred strains of mice and 11 F1 hybrid lines

03 / 2021:     Noll1
Immunoglobulin response to influenza A virus (H1N1) in females of 46 F1 hybrids of Collaborative Cross strains of mice (CC RIX)

12 / 2020:     Bubier3
Drug study: Opioid induced respiratory depression in 8 inbred founder strains of the Collaborative Cross

11 / 2020:     Auwerx1
Diet effects on metabolic phenotypes in males of 55 BXD recombinant inbred strains of mice fed a high-fat diet

11 / 2020:     Zimmermann1
Voluntary activity and energy expenditure in light and dark periods in 30 inbred strains of mice

10 / 2020:     Attie2
Diet effects on Type 2 diabetes associated physiological traits in a Diversity Outbred (DO) mouse population on a high-fat high-sucrose diet

09 / 2020:     JaxKOMP-EAP
Multisystem phenotyping of KOMP strains and C57BL/6NJ controls, early adult mice

09 / 2020:     JaxKOMP-LAP
Multisystem phenotyping of KOMP strains and C57BL/6NJ controls, late adult mice

07 / 2020:     Hallgrimsson1
Facial shape and allometry in a Diversity Outbred (DO) mouse population

06 / 2020:     Shorter4
Male reproduction in 12 Collaborative Cross strains of mice: Organ weights and sperm count, motility, and morphology

06 / 2020:     Shorter5
Male reproduction in 28 F1 hybrids of Collaborative Cross strains of mice (RIX): Organ weights and sperm count, motility, and morphology

06 / 2020:     Shorter6
Male reproduction in 12 Collaborative Cross strains of mice: Sperm motility (CASA)

06 / 2020:     Shorter7
Male reproduction in 28 F1 hybrids of Collaborative Cross strains of mice (RIX): Sperm motility (CASA)

06 / 2020:     Shorter8
Male reproduction in Diversity Outbred mice: Organ weights and sperm count, motility, and morphology

05 / 2020:     Molenhuis1
Social interaction and locomotor activity, digging, and grooming in males of 52 Collaborative Cross strains of mice

02 / 2020:     GMC01
Locomotor activity and exploratory and anxiety-related behaviors assessed by the open field test in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC02
Grip strength in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC03
Dysmorphology and SHIRPA behavioral and neuromuscular assessment in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC04
Motor coordination and balance assessed by the rotarod test in 7 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC05
Acoustic startle response and prepulse inhibition in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC06
Glucose levels and lipid profiles after fasting in 5 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC07
Thermal nociception assessed by the hot plate test in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC08
Transepidermal water loss in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC09
Energy metabolism evaluated through indirect calorimetry in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC10
Body composition assessed by NMR at two ages in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC11
Glucose tolerance test in 6 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC12
Heart function assessed by echocardiography in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC13
Heart function assessed by electrocardiography in 6 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC14
Eye morphology and vision assessment in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC15
Hematological parameters in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC16
Clinical blood chemistry for 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC17
Auditory brainstem response in 7 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC18
Bone mineral density, body composition, and X-ray analysis of 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC19
Lung function of females of 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC20
Circulating immunoglobulins, rheumatoid factor, and anti-DNA antibodies in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC21
Tibia length and heart, liver, and spleen weights in 8 inbred founder strains of the Collaborative Cross

02 / 2020:     GMC22
Growth curves for 8 inbred founder strains of the Collaborative Cross

02 / 2020:     UNC-GMUGA1
SNPs for 69 Collaborative Cross strains plus 8 founder strains, 130,000+ locations

01 / 2020:     HMDPpheno11
Diet effects on aortic lesion size in 103 Hybrid Mouse Diversity Panel strains that are transgenic for human APOE*3Leiden and human CETP (F1 hybrids)

11 / 2019:     Hadsell2
Analysis of milk minerals in 31 inbred strains of mice

11 / 2019:     Neuner1
Motor function, spatial learning and memory function, anxiety-related behaviors, and beta-amyloid levels in Alzheimer’s Disease mouse models (AD-BXD)

10 / 2019:     Zaytseva1
IgG glycome: Glycan levels in 111 Collaborative Cross strains of mice

10 / 2019:     Zaytseva2
IgG glycome: N-glycan profiles of IgG subclasses in 95 Collaborative Cross strains of mice

09 / 2019:     Recla2
Late phase formalin pain response in a Diversity Outbred (DO) mouse population

09 / 2019:     Xenakis1
Drug study: Haloperidol antipsychotic effects on behavioral phenotypes in 73 F1 hybrids of Collaborative Cross strains of mice (RIX)

04 / 2019:     Brinkmeyer1
Susceptibility to Theiler's murine encephalomyelitis virus in 5 Collaborative Cross strains of mice

04 / 2019:     JaxCC1
Multisystem phenotyping of 18 Collaborative Cross strains

04 / 2019:     Kumar2
Locomotor activity in 47 inbred strains of mice and 11 F1 hybrids

04 / 2019:     Sunde1
Selenium regulation of selenoprotein enzyme activity and transcripts in 8 inbred founder strains of the Collaborative Cross

03 / 2019:     Bolivar3
Intra-strain social interactions in 7 inbred strains of mice

03 / 2019:     Bolivar4
Intrasession and intersession changes in locomotor activity in response to a novel environment over time (habituation) in 14 inbred strains of mice

03 / 2019:     Lesage1
Immunological variation in 68 Collaborative Cross strains of mice and 8 founder strains

01 / 2019:     Bolivar1
Locomotor activity and exploratory behavior in 10 strains of mice

01 / 2019:     Bolivar2
Contextual and cued fear conditioning behavior in 8 inbred strains of mice

01 / 2019:     Jaxpheno18
Multi-system assessment of B6.129P2-Apoetm1Unc/J and B6.129S7-Ldlrtm1Her/J mice

01 / 2019:     Jaxpheno19
Multi-system assessment of MRL/MpJ-Faslpr/J mice

01 / 2019:     Payseur2
Hybrid male sterility in F2 progeny from a WSB/EiJ x PWD/PhJ intercross

01 / 2019:     Powell1
Susceptibility of 8 inbred founder strains of the Collaborative Cross to colonization by Neisseria musculi

12 / 2018:     JaxKOMP-Cre
Multi-system assessment of 7 Cre driver mouse strains

12 / 2018:     Jaxpheno20
Multi-system assessment of NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice

11 / 2018:     Graham1
West Nile virus infection in males of F1 hybrids (RIX) of Collaborative Cross strains of mice

11 / 2018:     Lazear1
Male reproductive traits in 12 Collaborative Cross strains of mice

11 / 2018:     Parker1
Superovulation in 6 commonly used mouse strains

10 / 2018:     Shorter3
Litter size and composition in a diallel of Collaborative Cross founder strains

10 / 2018:     Stahl1
Blood reference levels for hematology and clinical chemistry for C57BL/6J mice

07 / 2018:     Crusio1
Spatial learning, grooming, response to novelty, inter-male aggression, and hippocampal neuroanatomy in 53 BXD recombinant inbred strains of mice

07 / 2018:     McMullan4
Body weight and composition after voluntary exercise in females of 13 Collaborative Cross strains of mice

07 / 2018:     McMullan5
Activity levels, body weight and composition after voluntary exercise in females of 2 Collaborative Cross strains of mice

07 / 2018:     McMullan6
Body weight and composition after forced exercise in 4 Collaborative Cross strains of mice

07 / 2018:     McMullan7
Energy balance traits after forced exercise in 4 Collaborative Cross strains of mice

06 / 2018:     Jaxpheno17
Multi-system assessment of BKS.cg-Dock7m-Leprdb/J mice

06 / 2018:     UCLA1
SNP data, 132,000+ locations for 248 inbred and RI strains of mice

05 / 2018:     Bubier2
Gut microbial abundance QTL in Collaborative Cross emerging lines of mice

05 / 2018:     Chesler5
Intestinal microbiota in 10 inbred strains of mice

04 / 2018:     Rusyn10
Trichloroethylene metabolism in males of two inbred strains and an F1 hybrid

04 / 2018:     Rusyn11
Tetrachloroethylene metabolism in males of two inbred strains and an F1 hybrid

04 / 2018:     Schoenrock1
Perinatal nutrition effects on anxiety- and depression-related behaviors in females of F1 hybrids (RIX) of Collaborative Cross strains of mice

02 / 2018:     Jaxpheno12
Type 1 diabetes incidence and other phenotypes in NOD/ShiLtJ mice on a 6% fat diet

02 / 2018:     Jaxpheno13
Multi-system assessment of BALB/cJ mice

02 / 2018:     Jaxpheno14
Multi-system assessment of BALB/cByJ mice

02 / 2018:     Jaxpheno15
Multi-system assessment of B6.Cg-Lepob/J mice

02 / 2018:     Jaxpheno16
Multi-system assessment of B6.BKS(D)-Leprdb/J mice

02 / 2018:     McMullan1
Body composition and forced endurance in aging females of 50 Collaborative Cross strains of mice

02 / 2018:     McMullan2
Voluntary exercise traits in aging females of 43 Collaborative Cross strains of mice

02 / 2018:     McMullan3
Body composition responses following voluntary exercise in aging females of 43 Collaborative Cross strains of mice

09 / 2017:     Palmer3
Behavioral and metabolic traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/- for the Tcf7l2 gene

09 / 2017:     Palmer4
Behavioral traits in a panel of F1 hybrids involving 30 inbred strains and C57BL/6J males, where mice are +/- for the Cacna1c gene



Many other data sets have been released since MPD began in 2001.