Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.
Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2.
| Investigators |
Richard A Miller University of Michigan, Ann Arbor, MI Randy Strong University of Texas Health Science Center, San Antonio, TX Ron Korstanje The Jackson Laboratory, Bar Harbor, ME David E Harrison The Jackson Laboratory, Bar Harbor, ME Nadia A Rosenthal The Jackson Laboratory, Bar Harbor, ME |
| Contact | Richard A Miller millerr@umich.edu
|
| Affiliated Center | National Institute on Aging Interventions Testing Program (ITP) |
| Acknowledgements | Funding provided by NIH AG022303, AG022307, AG022308, AG066346 |
| Phenotype strain survey data set | |
| MPD identifiers | ITP2018 MPD:1224 |
| No updates/corrections. Initial release date: 03/2025. | |
|
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Compound name and |
Year cohort |
Dose in food |
Age at initiation |
Compound's effect on lifespan* |
Other phenotypes |
|
|---|---|---|---|---|---|---|
| fisetin |
C2018 | 600 ppm | 20 mo (3 days on/11 days off) and 20 mo (continuous) | [18] | ||
| SG1002 |
C2018 | 240 ppm | 18 mo | [18] |
* Log-rank test p-value on treated vs. control, shown when p ≤ 0.05 for each sex separately. Statistical definitions