ITP: ITP2019: Interventions Testing Program: Lifespan effects in UM-HET3 mice treated with 4-phenylbutarate, astaxanthin, dimethyl fumarate, meclizine, mycophenolic acid, and SG1002 (2024)

Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. Geroscience. 2024 Feb;46(1):795-816. doi: 10.1007/s11357-023-01011-0. Epub 2023 Dec 2.   PubMed 38041783     FullText


         
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Investigators Richard A Miller       University of Michigan,  Ann Arbor, MI
Randy Strong       University of Texas Health Science Center,  San Antonio, TX
Ron Korstanje       The Jackson Laboratory,  Bar Harbor, ME
David E Harrison       The Jackson Laboratory,  Bar Harbor, ME
Nadia A Rosenthal       The Jackson Laboratory,  Bar Harbor, ME
ContactRichard A Miller     millerr@umich.edu     Lab web site
Affiliated CenterNational Institute on Aging Interventions Testing Program (ITP)
AcknowledgementsFunding provided by NIH AG022303, AG022307, AG022308, AG066346
Project type Phenotype strain survey data set
MPD identifiersITP2019     MPD:1225
Data changelog No updates/corrections.       Initial release date: 03/2025.
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Study results by compound and year

Compound name and (abbreviation) Year
cohort		 Dose in food Age at initiation Compound's
effect on lifespan*		 Other phenotypes Ref#
4-phenylbutyrate (PBA) C2019 1000 ppm 9 mo View survival analysis   New [18]
astaxanthin (Asta) C2019 4000 ppm 12 mo View survival analysis   New
males p = 0.003 		[18]
dimethyl fumarate (DMF) C2019 120 ppm 9 or 16 mo View survival analysis   New [18]
meclizine (Mec) C2019 800 ppm 12 mo View survival analysis   New
males p = 0.027 		[18]
mycophenolic acid (MPA) C2019 6.7 ppm 9 mo View survival analysis   New [18]
SG1002 (SG1002) C2019 240 ppm 6 mo View survival analysis   New [18]

* Log-rank test p-value on treated vs. control, shown when p ≤ 0.05 for each sex separately. Statistical definitions