MPD: Data set: CSNA01

Eighty-seven strains of the hybrid mouse diversity panel (HMDP) and 4 wild-derived strains (males only) were characterized for oral sucrose self administration over 3 daily 8 hour sessions. Variation in rates of learning about rewards and motivation to seek them may underlie risk for psychiatric disorders such as substance abuse. Each session included fixed ratio 1 (for first 50 reinforcers) variable ratio 2 (for next 50 reinforcers) and variable ratio 5 schedules (remaining reinforcers). Reinforcers were capped at 500 per session. Mice were placed on food restriction to achieve 90% of free-feed body weight, beginning 6 days prior to sucrose self-administration and continuing through testing. This research was conducted within the inter-laboratory effort of the Center for Systems Neurogenetics of Addiction (CSNA) to characterize mouse strains for multiple, drug abuse related traits.

Procedures conducted:

• operant conditioning chamber		Rewards behavior and learning in a lever-based oral sucrose self-administering system. Daily 8 h sessions for 3 days.
• body weight		Effect on body weight of several days in a lever-based oral sucrose self-administering system.

Notes
Project data set includes supplemental measures.

CSNA01 downloads
• Download CSNA01 project data set animal data, as uploaded
• Download CSNA01 animal data matrix with factor-related expansion applied as necessary
• Download CSNA01 strain means, SD, N, etc. one row per strain/sex/measure
• Download CSNA01 supplementary file, Jentsch Sucrose SA.xlsx Original submission

Ontology terms mapped to CSNA01 measures:

Investigators	J D Jentsch Binghamton University, Binghamton, NY Jared Bagley Binghamton University, Binghamton, NY Alexander S James Binghamton University, Binghamton, NY Leona Gagnon The Jackson Laboratory, Bar Harbor, ME
Contact	J D Jentsch jjentsch@binghamton.edu Lab web site
Affiliated Center	Center for Systems Neurogenetics of Addiction (CSNA)
Acknowledgements	Funding provided by NIH DA27309, DA031852
Project type	Phenotype strain survey data set
MPD identifiers	CSNA01 MPD:602
Data changelog	No updates/corrections. Initial release date: 11/2025.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
CSNA01:1	CSNA01	operant conditioning chamber	sucrose	fixed ratio 1 (FR1), active lever presses, 8 h test [n] FR1active 60201 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:5	CSNA01	operant conditioning chamber	sucrose	fixed ratio 1 (FR1), lever press rate, 8 h test [n/s] FR1rate 60206 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:9	CSNA01	operant conditioning chamber	sucrose	variable ratio 2 (VR2), active lever presses, 8 h test [n] VR2active 60211 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:13	CSNA01	operant conditioning chamber	sucrose	variable ratio 2 (VR2), lever press rate, 8 h test [n] VR2rate 60216 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:17	CSNA01	operant conditioning chamber	sucrose	variable ratio 5 (VR5), active lever presses, 8 h test [n] VR5active 60221 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:21	CSNA01	operant conditioning chamber	sucrose	variable ratio 5 (VR5), lever press rate, 8 h test [n/s] VR5rate 60226 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:25	CSNA01	operant conditioning chamber	sucrose	active lever presses, 8 h test [n] Actives 60231 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:29	CSNA01	operant conditioning chamber	sucrose	reinforcers earned, 8 h test [n] Reinfs 60241 day 1 day 2 day 3 across 3 days	HMDP	91	m	7-22wks	N=4

CSNA01:33	CSNA01	operant conditioning chamber	sucrose	time elapsed before first reinforcer earned, 8 h test [s] FirstReinf 60251	HMDP	91	m	7-22wks	N=4

CSNA01:34	CSNA01	operant conditioning chamber	sucrose	time elapsed between earning first and fiftieth reinforcer, 8 h test [s] Time1to50 60252	HMDP	82	m	7-22wks	N=3

CSNA01:35	CSNA01	operant conditioning chamber	sucrose	whether criterion of 50 reinforcers earned was met, 8 h test (1=yes, 0=no) [score] Learned 60253	HMDP	91	m	7-22wks	N=4

CSNA01:36	CSNA01	body weight	(none)	body weight prior to testing [g] bw_pre 60261	HMDP	85	m	7-22wks	N=4

CSNA01:37	CSNA01	body weight	sucrose	percentage of starting body weight [%] bw 60271 day 1 before day 1 after day 2 before day 2 after day 3 before day 3 after (2 more)...	HMDP	84	m	7-22wks	N=4

CSNA01: Characterization of oral sucrose self administration in males of 87 strains of the Hybrid Mouse Diversity Panel (HMDP) and 4 wild-derived strains (2018)