Graham1: West Nile virus infection in males of F1 hybrids (RIX) of Collaborative Cross strains of mice (2015)

Graham JB, Thomas S, Swarts J, McMillan AA, Ferris MT, Suthar MS, Treuting PM, Ireton R, Gale M Jr, Lund JM. Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes. MBio. 2015 May 5;6(3):e00493-15. doi: 10.1128/mBio.00493-15.   PubMed 25944860  


         
Graham1 downloads
• Download Graham1 project data set     animal data, as uploaded
• Download Graham1 animal data matrix     with factor-related expansion applied as necessary
• Download Graham1 strain means, SD, N, etc.     one row per strain/sex/measure
• Graham1 supplementary data
Investigators Jessica B Graham       Fred Hutchinson Cancer Research Center,  Seattle, WA
Sunil Thomas       University of Washington,  Seattle, WA
Michael Gale Jr.       University of Washington,  Seattle, WA
Jennifer M Lund       Fred Hutchinson Cancer Research Center,  Seattle, WA
Participants Swarts J, McMillan AA, Ferris MT, Suthar MS, Treuting PM, Ireton R
ContactJessica B Graham     jgraham@fredhutch.org     Lab web site
AcknowledgementsFunding provided by NIH AI100625, AI04002, AI083019
Project type Phenotype strain survey data set
MPD identifiersGraham1     MPD:633
Data changelog No updates/corrections.       Initial release date: 11/2018.
Formatted citation
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Experimental groups in this study:
• None     • None     • None     • None     • None     • None     • None     • None     • None    

Procedures conducted:
• body weight 
• health assessment  Clinical score.
• immune cell quantification  T cell populations in brain and spleen.
• RNA expression profiling  Viral load and expression of Ifnb1 and Ifit1 in brain, kidney and spleen.

Mice: CC RIX   5 strains   ♂   age 8-10wks   9 experimental groups

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Graham1 body weight West Nile virus body weight, post infection   [g]  bw   63301     day 0    day 3    day 6    day 8    day 9    day 10    day 11    day 12    day 13    day 14    (4 more)... CC RIX 5 m 8-10wks N=12
    Graham1 health assessment West Nile virus clinical score (0=healthy, 1=lethargic, 2=altered gait, 3=no movement, 4=moribund), post infection   [score]  clin_score   63315     day 0    day 3    day 6    day 8    day 9    day 10    day 11    day 12    day 13    day 14    (4 more)... CC RIX 5 m 8-10wks N=12
    Graham1 immune cell quantification West Nile virus percentage of CD3+ T cells that are CD4+ in brain, post infection   [%]  CD4_brain   63329     day 7    day 12    day 21    day 28 CC RIX 5 m 8-10wks N=3
    Graham1 immune cell quantification West Nile virus percentage of CD3+ T cells that are CD4+ in spleen, post infection   [%]  CD4_spleen   63333     day 7    day 12    day 21    day 28 CC RIX 2 m 8-10wks N=3
    Graham1 immune cell quantification West Nile virus percentage of CD4+ T cells that are Foxp3+ in the brain, post infection   [%]  Treg_brain   63337     day 7    day 12    day 21    day 28 CC RIX 5 m 8-10wks N=3
    Graham1 immune cell quantification West Nile virus percentage of CD4+ T cells that are Foxp3+ in the spleen, post infection   [%]  Treg_spleen   63341     day 7    day 12    day 21    day 28 CC RIX 2 m 8-10wks N=3
    Graham1 immune cell quantification West Nile virus percentage of CD3+ T cells that are CD8+ in brain, post infection   [%]  CD8_brain   63345     day 7    day 12    day 21    day 28 CC RIX 5 m 8-10wks N=3
    Graham1 immune cell quantification West Nile virus percentage of CD3+ T cells that are CD8+ in spleen, post infection   [%]  CD8_spleen   63349     day 7    day 12    day 21    day 28 CC RIX 2 m 8-10wks N=3
    Graham1 immune cell quantification West Nile virus percentage of CD3+ T cells that are NS4b+ in brain, post infection   [%]  NS4b_brain   63353     day 7    day 12    day 21    day 28 CC RIX 5 m 8-10wks N=3
    Graham1 immune cell quantification West Nile virus percentage of CD3+ T cells that are NS4b+ in spleen, post infection   [%]  NS4b_spleen   63357     day 7    day 12    day 21    day 28 CC RIX 2 m 8-10wks N=3
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