MPD: Data set: Kliethermes1

Kliethermes1: Novelty seeking behavior in 14 inbred strains of mice (2006)

Kliethermes CL, Crabbe JC. Genetic independence of mouse measures of some aspects of novelty seeking. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5018-23. Epub 2006 Mar 21. PubMed 16551746 FullText

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Ontology terms mapped to Kliethermes1 measures:

MP:0000436 abnormal head movements
MP:0001392 abnormal locomotor behavior
MP:0003107 abnormal response to novelty
MP:0003461 abnormal response to novel object
MP:0013189 abnormal exploration in a new environment
VT:0001392 locomotor behavior trait
VT:0010459 behavioral response to novel environment trait
VT:0010471 exploratory behavior trait
VT:0010709 behavioral response to novel object trait
VT:0010732 head movement trait

Investigators	Christopher L Kliethermes Drake University, Des Moines, IA John C Crabbe Oregon Health & Science University, Portland, OR
Contact	Christopher L Kliethermes christopher.kliethermes@drake.edu Lab web site
Acknowledgements	Funding provided by NIH AA10760, AA015015, AA13519, AA12714; US Department of Veterans Affairs
Project type	Phenotype strain survey data set
MPD identifiers	Kliethermes1 MPD:599
Data changelog	No updates/corrections. Initial release date: 08/2017.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

High novelty seeking is correlated with risk for substance abuse. Mice were tested serially through the following five tests to assess novelty seeking: activity in a novel environment, novel environment preference, head dipping on a hole board, object preference on a hole board, and spontaneous alternation in a Y-maze.

Procedures conducted:

• monitoring system		Activity in a novel environment. Distance traveled, number of rears. 30 min test.
• two chamber assay		Novel environment preference. Activity in familiar and novel compartments. 20 min test.
• hole board test		Head dipping and other activity measures, hole board with and without objects in two of the holes. 10 min test.
• Y-maze		Spontaneous alternation.

Mice: inbred 14 strains ♀♂ age 8wks 1 experimental group

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)

Kliethermes1:1	Kliethermes1	monitoring system	(none)	distance traveled in a task to assess novelty seeking, 30 min test [cm] distance_MS 59901	inbred	14	both	8wks	N=6

Kliethermes1:2	Kliethermes1	monitoring system	(none)	number of rears in a task to assess novelty seeking, 30 min test [n] num_rears_MS 59902	inbred	14	both	8wks	N=6

Kliethermes1:3	Kliethermes1	monitoring system	(none)	time spent rearing in a task to assess novelty seeking, 30 min test [s] time_rears_MS 59903	inbred	14	both	8wks	N=6

Kliethermes1:4	Kliethermes1	monitoring system	(none)	residual score from regression of rears on horizontal activity in a task to assess novelty seeking, 30 min test [score] regression_MS 59904	inbred	14	both	8wks	N=6

Kliethermes1:11	Kliethermes1	two chamber assay	(none)	activity (beam breaks) in familiar compartment of novelty preference apparatus prior to preference test [n] activity_fam_prior_NP 59911	inbred	14	both	8wks	N=6

Kliethermes1:12	Kliethermes1	two chamber assay	(none)	activity (beam breaks) in familiar compartment of novelty preference apparatus, 20 min test [n] activity_fam_NP 59912	inbred	14	both	8wks	N=6

Kliethermes1:13	Kliethermes1	two chamber assay	(none)	activity (beam breaks) in novel compartment of novelty preference apparatus, 20 min test [n] activity_novel_NP 59913	inbred	14	both	8wks	N=6

Kliethermes1:16	Kliethermes1	two chamber assay	(none)	time spent in novel compartment of novelty preference apparatus, 20 min test [s] time_novel_NP 59916	inbred	14	both	8wks	N=6

Kliethermes1:17	Kliethermes1	two chamber assay	(none)	total activity (beam breaks) in novelty preference apparatus, 20 min test [n] tot_activity_NP 59917	inbred	14	both	8wks	N=6

Kliethermes1:18	Kliethermes1	two chamber assay	(none)	number of transitions between novel and familiar compartments in novelty preference apparatus, 20 min test [n] transitions_NP 59918	inbred	8	both	8wks	N=6

Kliethermes1:19	Kliethermes1	two chamber assay	(none)	residual score from regression of time spent in novel compartment on total activity in novelty preference apparatus, 20 min test [score] regression_time_NP 59919	inbred	14	both	8wks	N=6

Kliethermes1:20	Kliethermes1	two chamber assay	(none)	residual score from regression of activity in novel compartment on total activity in novelty preference apparatus, 20 min test [score] regression_activity_NP 59920	inbred	14	both	8wks	N=6

Kliethermes1:31	Kliethermes1	hole board test	(none)	distance traveled in head dip task to assess novelty seeking, 10 min test [cm] distance_HD 59931	inbred	14	both	8wks	N=6

Kliethermes1:32	Kliethermes1	hole board test	(none)	activity (beam breaks) in head dip task to assess novelty seeking, 10 min test [n] activity_HD 59932	inbred	14	both	8wks	N=6

Kliethermes1:33	Kliethermes1	hole board test	(none)	number of head dips in head dip task to assess novelty seeking, 10 min test [n] dips_HD 59933	inbred	14	both	8wks	N=6

Kliethermes1:34	Kliethermes1	hole board test	(none)	time spent head dipping in head dip task to assess novelty seeking, 10 min test [s] time_HD 59934	inbred	14	both	8wks	N=6

Kliethermes1:37	Kliethermes1	hole board test	(none)	residual score from regression of head dip count on horizontal activity in head dip task to assess novelty seeking, 10 min test [score] regression_HD 59937	inbred	14	both	8wks	N=6

Kliethermes1:38	Kliethermes1	hole board test	(none)	distance traveled in object preference task to assess novelty seeking, 10 min test [cm] distance_OP 59938	inbred	14	both	8wks	N=6

Kliethermes1:39	Kliethermes1	hole board test	(none)	activity (beam breaks) in object preference task to assess novelty seeking, 10 min test [n] activity_OP 59939	inbred	14	both	8wks	N=6

Kliethermes1:40	Kliethermes1	hole board test	(none)	number of head dips in object preference task to assess novelty seeking, 10 min test [n] dips_OP 59940	inbred	14	both	8wks	N=6

Kliethermes1:41	Kliethermes1	hole board test	(none)	time spent head dipping in object preference task to assess novelty seeking, 10 min test [s] time_OP 59941	inbred	14	both	8wks	N=6

Kliethermes1:42	Kliethermes1	hole board test	(none)	percentage of time spent head dipping during object preference task to assess novelty seeking, 10 min test [%] pct_time_OP 59942	inbred	14	both	8wks	N=6

Kliethermes1:43	Kliethermes1	hole board test	(none)	percentage of counts of head dipping at holes with objects during object preference task to assess novelty seeking, 10 min test [%] pct_num_OP 59943	inbred	14	both	8wks	N=6

Kliethermes1:44	Kliethermes1	hole board test	(none)	residual score from regression of object preference (count) on horizontal activity in object preference task to assess novelty seeking, 10 min test [score] regression_OP 59944	inbred	14	both	8wks	N=6

Kliethermes1:51	Kliethermes1	Y-maze	(none)	alternations during spontaneous alternation task to assess novelty seeking (0=same arm, 1=alternate arm) [n] alternation_Y 59951	inbred	14	both	8wks	N=6

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