Crabbe3: Drug study: Evaluation of ethanol intoxication using the rotarod in 22 inbred strains of mice (2003)

Rustay NR, Wahlsten D, Crabbe JC. Assessment of genetic susceptibility to ethanol intoxication in mice. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2917-22. Epub 2003 Feb 12.   PubMed 12584362  


         
Animals were evaluated on an accelerating and fixed speed rotarod following ethanol administration. This project has a complex study design involving multiple cohorts, as described in the protocol workflow table.

Procedures conducted:
• body weight 
• rotarod  Baseline and ethanol i.p. 3 fixed speeds (several doses) and accelerating.

Crabbe3 downloads
• Download Crabbe3 project data set     animal data, as uploaded
• Download Crabbe3 animal data matrix     with factor-related expansion applied as necessary
• Download Crabbe3 strain means, SD, N, etc.     one row per strain/sex/measure
• Crabbe3 supplementary data
Investigators John C Crabbe       Oregon Health & Science University,  Portland, OR
Douglas Wahlsten       University of Windsor,  Windsor, Ontario CANADA
Participants Rustay NR
ContactJohn C Crabbe     crabbe@ohsu.edu
AcknowledgementsGenerous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type Phenotype strain survey data set
MPD identifiersCrabbe3     MPD:158
Data changelog No updates/corrections.       Initial release date: 02/2010.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Mice: inbred   22 strains   ♀♂   age 9-17wks   9 experimental groups

Select table page: First Prev 1 - 10 / 13 (13) Next Last
Sort/
Pick
Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
    Crabbe3 body weight (none) body weight on test day (local parameter)   [g]  bw   15801 inbred 9 both 9-17wks N=17
    Crabbe3 rotarod ethanol latency to fall, fixed speed 3 rpm rotarod   [s]  FS_3rpm_EtOH   15810     dose (g/kg): 1    2    3 inbred 9 both 9-17wks N=4
    Crabbe3 rotarod ethanol latency to fall, fixed speed 6 rpm rotarod   [s]  FS_6rpm_EtOH   15815     dose (g/kg) 1    2    3 inbred 9 both 9-17wks N=3
    Crabbe3 rotarod ethanol latency to fall, fixed speed 10 rpm rotarod   [s]  FS_10rpm_EtOH   15820     dose (g/kg): 1    2    3 inbred 9 both 9-17wks N=3
    Crabbe3 rotarod (none) accelerating rotarod (ARR1) acquisition trial average over all trials (20 rpm/min)   [s]  ARR1_performance   15830 inbred 8 both 9-17wks N=6
    Crabbe3 rotarod (none) accelerating rotarod (ARR1) acquisition trial average of last 3 trials minus average of first 3 trials (20 rpm/min)   [s]  ARR1_improvement   15831 inbred 8 both 9-17wks N=6
    Crabbe3 rotarod ethanol latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1)   [s]  ARR1_20rpm   15840     baseline    ethanol    difference inbred 8 both 9-17wks N=6
    Crabbe3 rotarod ethanol latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1)   [s]  ARR1_30rpm   15845     baseline    ethanol    difference inbred 8 both 9-17wks N=6
    Crabbe3 rotarod (none) accelerating rotarod (ARR2) acquisition trial average over all trials (20 rpm/min)   [s]  ARR2_performance   15850 inbred 21 both 9-17wks N=9
    Crabbe3 rotarod (none) accelerating rotarod (ARR2) acquisition trial average of first 2 trials minus average of last 2 trials (20 rpm/min)   [s]  ARR2_improvement   15851 inbred 21 both 9-17wks N=9
    All boxes             To see more rows use the paging control at top.