MPD: Project measures / variables set: Wiltshire4 Tcells

Project measures / variables set: Wiltshire4 Tcells_Dox

ID, description, units	MPD:52427 Tcells_Dox T cells, percent viability [%] doxorubicin study
Measures	• dose [µM]: • control • 0.046 • 0.137 • 1.235 • 11.1 • 100
Data set, strains	Wiltshire4 inbred w/CC7 35 strains sex: m age: 10wks
Procedure	immune cell quantification
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0006387 T cell quantity VT:0010487 response to xenobiotic stimulus trait MA:0000141 spleen MP:0006387 abnormal T cell number MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Wiltshire4 - T cells, percent viability

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	5	98867.4594	19773.4919	355.6268	< 0.0001
strain	33	51210.4266	1551.8311	27.9097	< 0.0001
dose:strain	165	88833.3575	538.384	9.6829	< 0.0001
Residuals	593	32971.8729	55.6018

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Wiltshire4	52427	immune cell quantification	doxorubicin	T cells, percent viability [%] control Tcells_Dox_ctrl	inbred w/CC7	35	m	10wks
Wiltshire4	52428	immune cell quantification	doxorubicin	T cells, percent viability [%] dose: 0.046 µM Tcells_Dox_A	inbred w/CC7	35	m	10wks
Wiltshire4	52429	immune cell quantification	doxorubicin	T cells, percent viability [%] dose: 0.137 µM Tcells_Dox_B	inbred w/CC7	35	m	10wks
Wiltshire4	52430	immune cell quantification	doxorubicin	T cells, percent viability [%] dose: 1.235 µM Tcells_Dox_C	inbred w/CC7	35	m	10wks
Wiltshire4	52431	immune cell quantification	doxorubicin	T cells, percent viability [%] dose: 11.1 µM Tcells_Dox_D	inbred w/CC7	35	m	10wks
Wiltshire4	52432	immune cell quantification	doxorubicin	T cells, percent viability [%] dose: 100 µM Tcells_Dox_E	inbred w/CC7	35	m	10wks