Vanderlinden1: Drinking in the dark alcohol consumption in 43 ILSXISS recombinant inbred strains of mice (2015)

Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff . Influence of sex on genetic regulation of 'drinking in the dark' alcohol consumption. Mamm Genome. 2015 Feb;26(1-2):43-56. doi: 10.1007/s00335-014-9553-8. Epub 2015 Jan 6.   PubMed 25559016     FullText


         
ILSXISS recombinant inbred mice were used to investigate genetic influences of alcohol consumption in the "drinking in the dark" model. Mice were given access to 20% ethanol during the early phase of their circadian dark cycle for four consecutive days. Alcohol-preferring strains of mice consume an amount of alcohol during this time that produces blood ethanol levels that are comparable to the levels that define binge drinking in humans.

Procedures conducted:
• body weight 
• intake monitoring  Ethanol consumed during 2h availability during dark phase. 4 days/trials with variations.

Vanderlinden1 downloads
• Download Vanderlinden1 project data set     animal data, as uploaded
• Download Vanderlinden1 animal data matrix     with factor-related expansion applied as necessary
• Download Vanderlinden1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Lauren A Vanderlinden       University of Colorado,  Aurora, CO
Laura Saba       University of Colorado Denver School of Medicine,  Aurora, CO
Beth Bennett       University of Colorado Denver School of Medicine,  Aurora, CO
Paula A Hoffman       University of Colorado Denver School of Medicine,  Aurora, CO
Boris Tabakoff       University of Colorado Denver School of Medicine,  Aurora, CO
ContactLauren A Vanderlinden     lauren.vanderlinden@ucdenver.edu
AcknowledgementsFunding provided by NIH AA013162, AA16649; Banbury Fund
Project type Phenotype strain survey data set
MPD identifiersVanderlinden1     MPD:543
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
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Mice: ILSXISS   43 strains   ♀♂   age 8-23wks   1 experimental group

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Vanderlinden1 body weight (none) body weight at start of experiment on day 1   [g]  bw   54301 ILSXISS 43 both 8-23wks N=8
    Vanderlinden1 intake monitoring (none) ethanol consumed 'drinking in the dark'   [g]  EtOH   54311     day2    day3    day4 ILSXISS 43 both 8-23wks N=8
    Vanderlinden1 intake monitoring (none) ethanol consumed 'drinking in the dark', log transformed   [log(g)]  EtOH_log   54321     day2    day3    day4 ILSXISS 43 both 8-23wks N=8
    Vanderlinden1 intake monitoring (none) first principal component on log transformed 'drinking in the dark' measurements (days 2, 3, 4)  PC1   54331 ILSXISS 43 both 8-23wks N=8
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