Petkova1: Aging study: Peripheral blood leukocytes (PBL profiles) in 32 inbred strains of mice (2007)

Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, Paigen B. Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. Physiol Genomics. 2008 Aug 15;34(3):304-14. Epub 2008 Jun 10.   PubMed 18544662     FullText


         
An investigation of aging effects on immune system. Animals were evaluated using flow cytometry.

Procedures conducted:
• complete blood count  Hematology. Aging study, 6mo, 12mo, 18mo, 24mo.
• immune cell quantification  Aging study, 6mo, 12mo, 18mo, 24mo.

Petkova1 downloads
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Investigators Stefka Petkova       The Jackson Laboratory,  Bar Harbor, ME
Derry Roopenian       The Jackson Laboratory,  Bar Harbor, ME
Participants Schultz D, Godfrey D
ContactDerry Roopenian     derry.roopenian@jax.org     Lab web site
Affiliated CenterJAX Nathan Shock Aging Center
AcknowledgementsFunding provided by NIH AG025707 (NIA Nathan Shock Center for Aging Research); The Ellison Medical Foundation
Project type Phenotype strain survey data set
MPD identifiersPetkova1     MPD:242
Data changelog 1 update/correction.       Initial release date: 06/2009.
Formatted citation
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Mice: inbred   32 strains   ♀♂   age 26, 52, 78, 104 wks   1 experimental group

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Petkova1 immune cell quantification (none) white blood cell count (WBC; per volume x 103)   [n/µL]  WBC   24201     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 immune cell quantification (none) lymphocyte differential (LYM; percentage of total WBC)   [%]  LYM   24206     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 immune cell quantification (none) neutrophil differential (NEUT; percentage of total WBC)   [%]  NEUT   24211     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 immune cell quantification (none) eosinophil differential (EOS; percentage of total WBC)   [%]  EOS   24216     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 immune cell quantification (none) monocyte differential (MONO; percentage of total WBC)   [%]  MONO   24221     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 immune cell quantification (none) B cells, as percentage of total lymphocytes   [%]  B_cells   24225     6mo    12mo    18mo    24mo inbred 32 both N=7
    Petkova1 immune cell quantification (none) CD4 T cells, as percentage of total lymphocytes   [%]  CD4_all   24229     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 immune cell quantification (none) CD4 T cells, naive, as percentage of total CD4 T cells   [%]  CD4_naive   24233     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 immune cell quantification (none) CD4 T cells, central memory, as percentage of total CD4 T cells   [%]  CD4_mem_central   24237     6mo    12mo    18mo    24mo inbred 32 both N=8
    Petkova1 immune cell quantification (none) CD4 T cells, effector memory, as percentage of total CD4 T cells   [%]  CD4_mem_effector   24241     6mo    12mo    18mo    24mo inbred 32 both N=8
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