MPD: Data set: Petkova1

Petkova SB, Yuan R, Tsaih SW, Schott W, Roopenian DC, Paigen B. Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages. Physiol Genomics. 2008 Aug 15;34(3):304-14. Epub 2008 Jun 10. PubMed 18544662 FullText

An investigation of aging effects on immune system. Animals were evaluated using flow cytometry.

Procedures conducted:

• complete blood count		Hematology. Aging study, 6mo, 12mo, 18mo, 24mo.
• immune cell quantification		Aging study, 6mo, 12mo, 18mo, 24mo.

Petkova1 downloads
• Download Petkova1 project data set animal data, as uploaded
• Download Petkova1 animal data matrix with factor-related expansion applied as necessary
• Download Petkova1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Petkova1 measures:

MA:0000059 blood
MP:0000217 abnormal leukocyte cell number
MP:0000717 abnormal lymphocyte cell number
MP:0002458 abnormal B cell number
MP:0002602 abnormal eosinophil cell number
MP:0008043 abnormal NK cell number
MP:0008073 abnormal CD4-positive, alpha beta T cell number
MP:0008077 abnormal CD8-positive, alpha-beta T cell number
MP:0010849 abnormal effector memory CD8-positive, alpha-beta T cell number
MP:0012440 abnormal neutrophil cell number
MP:0012441 abnormal monocyte cell number
MP:0012769 abnormal CD4-positive, alpha-beta memory T cell number
MP:0012770 abnormal effector memory CD4-positive, alpha-beta T cell number
MP:0012772 abnormal central memory CD8-positive, alpha-beta T cell number
VT:0000217 leukocyte quantity
VT:0000222 neutrophil quantity
VT:0000223 monocyte quantity
VT:0000717 lymphocyte quantity
VT:0002458 B cell quantity
VT:0002602 eosinophil quantity
VT:0008043 natural killer cell quantity
VT:0008073 CD4-positive T cell quantity
VT:0008077 CD8-positive T cell quantity

Investigators	Stefka Petkova The Jackson Laboratory, Bar Harbor, ME Derry Roopenian The Jackson Laboratory, Bar Harbor, ME
Participants	Schultz D, Godfrey D
Contact	Derry Roopenian derry.roopenian@jax.org Lab web site
Affiliated Center	JAX Nathan Shock Aging Center
Acknowledgements	Funding provided by NIH AG025707 (NIA Nathan Shock Center for Aging Research); The Ellison Medical Foundation
Project type	Phenotype strain survey data set
MPD identifiers	Petkova1 MPD:242
Data changelog	1 update/correction. Initial release date: 06/2009.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Sample Size (Avg)
Petkova1:1	Petkova1	immune cell quantification	(none)	white blood cell count (WBC; per volume x 10³) [n/µL] WBC 24201 6mo 12mo 18mo 24mo	inbred	32	both	N=7

Petkova1:6	Petkova1	immune cell quantification	(none)	lymphocyte differential (LYM; percentage of total WBC) [%] LYM 24206 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:11	Petkova1	immune cell quantification	(none)	neutrophil differential (NEUT; percentage of total WBC) [%] NEUT 24211 6mo 12mo 18mo 24mo	inbred	32	both	N=7

Petkova1:16	Petkova1	immune cell quantification	(none)	eosinophil differential (EOS; percentage of total WBC) [%] EOS 24216 6mo 12mo 18mo 24mo	inbred	32	both	N=7

Petkova1:21	Petkova1	immune cell quantification	(none)	monocyte differential (MONO; percentage of total WBC) [%] MONO 24221 6mo 12mo 18mo 24mo	inbred	32	both	N=7

Petkova1:25	Petkova1	immune cell quantification	(none)	B cells, as percentage of total lymphocytes [%] B_cells 24225 6mo 12mo 18mo 24mo	inbred	32	both	N=7

Petkova1:29	Petkova1	immune cell quantification	(none)	CD4 T cells, as percentage of total lymphocytes [%] CD4_all 24229 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:33	Petkova1	immune cell quantification	(none)	CD4 T cells, naive, as percentage of total CD4 T cells [%] CD4_naive 24233 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:37	Petkova1	immune cell quantification	(none)	CD4 T cells, central memory, as percentage of total CD4 T cells [%] CD4_mem_central 24237 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:41	Petkova1	immune cell quantification	(none)	CD4 T cells, effector memory, as percentage of total CD4 T cells [%] CD4_mem_effector 24241 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:46	Petkova1	immune cell quantification	(none)	CD4 T cells, effector, as percentage of total CD4 T cells [%] CD4_effector 24246 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:51	Petkova1	immune cell quantification	(none)	CD8 T cells, as percentage of total lymphocytes [%] CD8_all 24251 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:56	Petkova1	immune cell quantification	(none)	CD8 T cells, naive, as percentage of total CD8 T cells [%] CD8_naive 24256 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:61	Petkova1	immune cell quantification	(none)	CD8 T cells, central memory, as percentage of total CD8 T cells [%] CD8_mem_central 24261 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:66	Petkova1	immune cell quantification	(none)	CD8 T cells, effector memory, as percentage of total CD8 T cells [%] CD8_mem_effector 24266 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:71	Petkova1	immune cell quantification	(none)	CD8 T cells, effector, as percentage of total CD8 T cells [%] CD8_effector 24271 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1:76	Petkova1	immune cell quantification	(none)	natural killer (NK) cells, as percentage of total lymphocytes [%] NK 24276 6mo 12mo 18mo 24mo	inbred	32	both	N=8

Petkova1: Aging study: Peripheral blood leukocytes (PBL profiles) in 32 inbred strains of mice (2007)