MPD: Data set: Korstanje3

Korstanje3: HDL cholesterol and phospholipid transfer activity in F2 progeny from an SM/J x NZB/BlNJ intercross (2004) [Pending]

Korstanje R, Albers JJ, Wolfbauer G, Li R, Tu AY, Churchill GA, Paigen BJ. Quantitative Trait Locus Mapping of Genes That Regulate Phospholipid Transfer Activity in SM/J and NZB/BlNJ Inbred Mice. Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):155-60. Epub 2003 Oct 30. PubMed 14592843

Korstanje R, Li R, Howard T, Kelmenson P, Marshall J, Paigen B, Churchill G. Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population. J Lipid Res. 2004 May;45(5):881-8. Epub 2004 Mar 1. PubMed 14993241

Korstanje3 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Korstanje3 measures:

MA:0002501 plasma
MP:0000180 abnormal circulating cholesterol level
MP:0000184 abnormal circulating HDL cholesterol level
MP:0012780 abnormal phospholipid transfer protein activity
VT:0000180 blood cholesterol amount
VT:0000184 blood HDL cholesterol amount
VT:0006084 blood phospholipid amount

Investigators	Ron Korstanje The Jackson Laboratory, Bar Harbor, ME
Participants	Albers JJ, Wolfbauer G, Li R, Tu AY, Churchill GA, Paigen BJ
Contact	Ron Korstanje ron.korstanje@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Funding provided by NIH HL30086, HL66611
Project type	QTL Archive data set
MPD identifiers	Korstanje3 MPD:141
Data changelog	This project has not yet been released.

An intercross between SM/J x NZB/BlNJ inbred mouse strains was generated to identify QTLs that are involved in regulating phospholipid transfer activity (PLTP) and HDL cholesterol levels. PLTP activity, total cholesterol, and HDL cholesterol were measured in mice administered a high-fat (15%) diet from 8-24 wks of age (16 wks on high fat diet). Plasma was obtained from fasted mice (4 hr) at 8 wks (baseline), 14, 20, and 24 wks. For detailed protocols see publications (below).

QTL data set parameters:

Progenitor strains	NZB/BlNJ SM/J
Cross type	F2 intercross
Population size	258 ♀ 258 ♂

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Korstanje3	protein activity assessment	(none)	plasma PLTP activity, chow [µmol/mL/h] PLTP_chow 14101	QTL population	both	8wks	N=258

Korstanje3	protein activity assessment	high-fat diet	plasma PLTP activity, high-fat diet [µmol/mL/h] PLTP_fat 14102	QTL population	both	14wks	N=258

Korstanje3	protein activity assessment	high-fat diet	plasma PLTP, ratio of chow to high-fat diet, log transformed [log(ratio)] PLTP_ratio 14103	QTL population	both	14wks	N=258

Korstanje3	protein activity assessment	high-fat diet	plasma PLTP, difference between high-fat and chow diets [µmol/mL/h] PLTP_diff 14104	QTL population	both	14wks	N=258

Korstanje3	protein activity assessment	high-fat diet	plasma PLTP, percent change between chow and high-fat diet [%] PLTP_chg 14105	QTL population	both	14wks	N=258

Korstanje3	lipid profile	(none)	total cholesterol (plasma), chow [mg/dL] chol_chow 14106	QTL population	both	8wks	N=258

Korstanje3	lipid profile	high-fat diet	total cholesterol (plasma), high-fat diet 6 wks [mg/dL] chol_fat6 14107	QTL population	both	14wks	N=258

Korstanje3	lipid profile	high-fat diet	total cholesterol (plasma), high-fat diet 12 wks [mg/dL] chol_fat12 14108	QTL population	both	20wks	N=258

Korstanje3	lipid profile	high-fat diet	total cholesterol (plasma), high-fat diet 16 wks [mg/dL] chol_fat16 14109	QTL population	both	24wks	N=258

Korstanje3	lipid profile	(none)	HDL cholesterol (plasma), chow [mg/dL] HDLC_chow 14110	QTL population	both	8wks	N=258

Korstanje3	lipid profile	high-fat diet	HDL cholesterol (plasma), high-fat diet 6 wks [mg/dL] HDLC_fat6 14111	QTL population	both	14wks	N=258

Korstanje3	lipid profile	high-fat diet	HDL cholesterol (plasma), high-fat diet 12 wks [mg/dL] HDLC_fat12 14112	QTL population	both	20wks	N=258

Korstanje3	lipid profile	high-fat diet	HDL cholesterol (plasma), high-fat diet 16 wks [mg/dL] HDLC_fat16 14113	QTL population	both	24wks	N=258

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Project / data set: Korstanje3 a.k.a. Korstanje_2004

QTL file list not available on this MPD instance.