MPD: Data set: Frankel1

Frankel WN, Taylor L, Beyer B, Tempel BL, White HS. Electroconvulsive thresholds of inbred mouse strains. Genomics. 2001 Jun 15;74(3):306-12. PubMed 11414758

An electroconvulsive threshold test was applied to assess frontal and transcorneal induced seizures and their suppression with lamotrigene. For each strain/sex/measurement the following summary data were supplied: median value, N, and the 95% confidence interval. (In this project these median values are referred to as "means" in MPD data displays but they are really medians as described). Measurements for individual mice were not supplied. Assays were performed at two sites, Bar Harbor and Salt Lake City. Measurement descriptions use the following abbreviations:
"CC50" = Critical current (milli Amps) for 50% of the mice of a strain to reach seizure response (endpoint)
"CC97" = Critical current (milli Amps) for 97% of the mice of a strain to reach seizure response (endpoint)
"ED50" = Median effective dose (mg/kg)
"BH" = Assays performed in Bar Harbor
"SL" = Assays performed in Salt Lake City

Procedures conducted:

• electroconvulsion test

Electroconvulsive thresholds. Lamotrigine. 2 test sites.

Frankel1 downloads
• Download Frankel1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Frankel1 measures:

MA:0000168 brain
MP:0000950 abnormal seizure response to pharmacological agent
MP:0001650 abnormal seizure response to electrical stimulation
MP:0008872 abnormal physiological response to xenobiotic
VT:0010487 response to xenobiotic stimulus trait
VT:0015058 brain physiology trait

Investigators	Wayne N Frankel The Jackson Laboratory, Bar Harbor, ME H Steve White University of Utah, Salt Lake City, UT
Participants	Taylor L, Beyer B, Tempel BL
Contact	Wayne N Frankel wnf@jax.org
Acknowledgements	Funding provided by NIH NS40246.
Project type	Phenotype strain survey data set
MPD identifiers	Frankel1 MPD:56
Data changelog	1 update/correction. Initial release date: 05/2001.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Frankel1:1	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀) for minimal clonic seizure, frontal stimulation (at BH) [mA] E_MC_BH_FS 5601	inbred	4	m	6-11wks	N=35

Frankel1:2	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀), transcorneal stimulation (at BH) [mA] E_MC_BH_TC 5602	inbred	16	both	6-11wks	N=33

Frankel1:3	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀), transcorneal stimulation (at SL) [mA] E_MC_SL_TC 5603	inbred	8	both	6-11wks	N=29

Frankel1:4	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀) for maximal tonic hindlimb extension seizure, frontal stimulation (at BH) [mA] E_MT_BH_FS 5604	inbred	4	m	6-11wks	N=44

Frankel1:5	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀) for maximal tonic hindlimb extension seizure, transcorneal stimulation (at BH) [mA] E_MT_BH_TC 5605	inbred	16	both	6-11wks	N=38

Frankel1:6	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀) for maximal tonic hindlimb extension seizure, transcorneal stimulation (at SL) [mA] E_MT_SL_TC 5606	inbred	8	both	6-11wks	N=29

Frankel1:7	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀) for psychomotor seizure, frontal stimulation (at BH) [mA] E_PS_BH_FS 5607	inbred	4	m	6-11wks	N=41

Frankel1:8	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀) for psychomotor seizure, transcorneal stimulation (at BH) [mA] E_PS_BH_TC 5608	inbred	14	both	6-11wks	N=41

Frankel1:9	Frankel1	electroconvulsion test	(none)	median critical current (CC₅₀) for psychomotor seizure, transcorneal stimulation (at SL) [mA] E_PS_SL_TC 5609	inbred	7	both	6-11wks	N=39

Frankel1:10	Frankel1	electroconvulsion test	lamotrigine	median effective dose (ED₅₀) against minimal clonic seizures (CC₉₇), transcorneal stimulation (at BH) [mg/kg] L_MC_BH_TC 5610	inbred	3	m	6-11wks	N=63

Frankel1:12	Frankel1	electroconvulsion test	lamotrigine	median effective dose (ED₅₀) against minimal clonic seizures (CC₉₇), transcorneal stimulation (at SL) [mg/kg] L_MC_SL_TC 5612	inbred	3	m	6-11wks	N=51

Frankel1:13	Frankel1	electroconvulsion test	lamotrigine	median effective dose (ED₅₀) against maximal tonic hindlimb extension seizure (CC₉₇), transcorneal stimulation (at BH) [mg/kg] L_MT_BH_TC 5613	inbred	3	m	6-11wks	N=52

Frankel1:14	Frankel1	electroconvulsion test	lamotrigine	median effective dose (ED₅₀) against maximal tonic hindlimb extension seizure (CC₉₇), transcorneal stimulation (at SL) [mg/kg] L_MT_SL_TC 5614	inbred	3	m	6-11wks	N=45

Frankel1: Drug study: Induced seizures and their suppression with lamotrigine in 16 inbred strains of mice (2000)