Dickson2: Novelty-related behaviors and intravenous cocaine self-administration in a Diversity Outbred (DO) mouse population (2015)

Dickson PE, Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin DT, Chesler EJ. Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice. Psychopharmacology (Berl). 2015 Mar;232(6):1011-24. doi: 10.1007/s00213-014-3737-5. Epub 2014 Sep 20.   PubMed 25238945     FullText


         
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Investigators Price E Dickson       The Jackson Laboratory,  Bar Harbor, ME
Elissa J Chesler       The Jackson Laboratory,  Bar Harbor, ME
Participants Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin D-T
ContactPrice E Dickson     price.dickson@jax.org
Affiliated CenterCenter for Systems Neurogenetics of Addiction (CSNA)
AcknowledgementsFunding provided by NIH CA034196, GM076468; acknowledge support from NIDA Drug Supply Program
Project type Phenotype strain survey data set
MPD identifiersDickson2     MPD:548
Data changelog No updates/corrections.       Initial release date: 06/2016.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
FR = fixed ratio; PR = progressive ratio;

Procedures conducted:
• open field test  Locomotor activity and exploratory behavior. 20 min test.
• hole board test  Exploratory behavior. 10 min test.
• monitoring system  Novelty preference test (preference for novel side vs. familiar side). 10 min test.
• operant conditioning chamber  Intravenous self-administration of cocaine via activation of levers.

Mice: DO population   ♀♂   age 12-16wks   1 experimental group

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Dickson2 open field test (none) total distance traveled, 20 min test   [cm]  OFT_distance   54801 DO population both 12-16wks N=48
    Dickson2 open field test (none) time spent in center, 20 min test   [s]  OFT_center   54802 DO population both 12-16wks N=48
    Dickson2 monitoring system (none) percentage of total time spent in chamber with novel wall, 10 min test   [%]  novel_wall   54811 DO population both 12-16wks N=48
    Dickson2 hole board test (none) number of hole pokes, 10 min test   [n]  hole_pokes   54821 DO population both 12-16wks N=46
    Dickson2 operant conditioning chamber cocaine intravenous self-administration, mean number of infusions (fixed ratio 1 (FR1) schedule), over ten 120 min sessions   [n]  FR1_infusions_mean   54831 DO population both 12-16wks N=35
    Dickson2 operant conditioning chamber cocaine intravenous self-administration, mean number of responses on the active lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions   [n]  FR1_active_mean   54832 DO population both 12-16wks N=35
    Dickson2 operant conditioning chamber cocaine intravenous self-administration, mean number of responses on the inactive lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions   [n]  FR1_inactive_mean   54833 DO population both 12-16wks N=35
    Dickson2 operant conditioning chamber cocaine intravenous self-administration, breakpoint for infusions (progressive ratio (PR) schedule), one 6h test   [n]  PR_infusions_breakpoint   54841 DO population both 12-16wks N=31
    Dickson2 operant conditioning chamber cocaine intravenous self-administration, number of presses on the active lever (progressive ratio (PR) schedule), one 6h test   [n]  PR_active   54842 DO population both 12-16wks N=31
    Dickson2 operant conditioning chamber cocaine intravenous self-administration, number of presses on the inactive lever (progressive ratio (PR) schedule), one 6h test   [n]  PR_inactive   54843 DO population both 12-16wks N=31
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