Chesler6: Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J x 129S1/SvImJ inbred mouse cross (2012)

Chesler EJ, Plitt A, Fisher D, Hurd B, Lederle L, Bubier JA, Kiselycznyk C, Holmes A. Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J × 129S1/SvImJ inbred mouse cross. Mamm Genome. 2012 Jun;23(5-6):305-2Epub 2012 Feb 28.   PubMed 22371272  


       
Individual variation in sensitivity to acute ethanol (EtOH) challenge is associated with alcohol drinking and abuse. Inbred strain C57BL/6J (B6) and 129S1/SvImJ (S1) showed different responses on certain measures of acute EtOH intoxication. To gain insight into genetic factors contributing to these differences, a QTL analysis of EtOH traits was performed in B6x129S1 F2 population. The result revealed several additive and interacting loci, and the QTLs for different EtOH phenotypes were largely non-overlapping. For detailed protocols, see Chesler et al 2012.

Note on studied population: C57BL/6J x 129S1/SvImJ

Procedures conducted:
• study archive  Sensitivity to ethanol. Baseline and ethanol.

Chesler6 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Investigators Elissa J Chesler       The Jackson Laboratory,  Bar Harbor, ME
Participants Plitt A, Fisher D, Hurd B, Lederle L, Bubier JA, Kiselycznyk C, Holmes A
ContactElissa J Chesler     elissa.chesler@jax.org
Affiliated CenterQTL Archive
AcknowledgementsResearch supported by the National Institute of Alcohol Abuse and Alcoholism Intramural Research Program (Z01 AA000411). EJC is supported by The Jackson Laboratory and R01 AA18776.
Project type QTL Archive data set
MPD identifiersChesler6     MPD:271
Data changelog No updates/corrections.       Initial release date: 03/2012.
QTL data set parameters:
Progenitor strains 129S1/SvImJ     C57BL/6J    
Cross typeF2 reciprocal intercross
Population size 178 ♀     195 ♂
Notesone mouse was missing sex infomation
Age9-34wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Eih3   Eih4   Eih5   Elorr3  


Project / data set:   Chesler6     a.k.a. Chesler_2012
Excel file:   Data_Description_B6x129S_Chesler2012.xlsx
CSV file:   Chesler2012_B6x129S_B37_Data.csv
Readme / text file:   readme_Chesler2012.txt
QC plots, figures, etc.:   Chr12RFplot_Chesler2012.png
QC plots, figures, etc.:   MapComparison_Chesler2012.png
QC plots, figures, etc.:   Mapplot_Chesler2012.png
QC plots, figures, etc.:   MissingGeno_Chesler2012.png
QC plots, figures, etc.:   RFplot_Chesler2012.png