MPD: Project measures / variables set: Paigen2 CHOL

Project measures / variables set: Paigen2 CHOL

ID, description, units	MPD:9906 CHOL total cholesterol (plasma) [mg/dL] high-fat diet study
Measures	• baseline • after 17wks on diet • Δchange
Data set, strains	Paigen2 inbred w/CC7 42 strains sex: both age: 7-9wks
Procedure	lipid profile
Comparison	repeated measures, baseline then treated, same cohort
Ontology mappings	VT:0000180 blood cholesterol amount MA:0002501 plasma MP:0000180 abnormal circulating cholesterol level

Values Means Δ Means Z-scores

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Paigen2 - total cholesterol (plasma)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	35076.027	35076.027	7.4344	0.0066
between strain	33	11815340.9412	358040.6346	75.8867	< 0.0001
between sex:strain	33	1234319.4178	37403.6187	7.9277	< 0.0001
between Residuals	505	2382636.6104	4718.0923
within group	1	8634447.3613	8634447.3613	1852.993	< 0.0001
within group:sex	1	5839.2839	5839.2839	1.2531	0.2635
within group:strain	33	11601059.4881	351547.2572	75.4437	< 0.0001
within group:sex:strain	33	1217753.1505	36901.6106	7.9193	< 0.0001
within Residuals	505	2353163.7163	4659.7301

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Paigen2	9906	lipid profile	high-fat diet	total cholesterol (plasma) [mg/dL] baseline CHOL	inbred w/CC7	42	both	7-9wks
Paigen2	9909	lipid profile	high-fat diet	total cholesterol (plasma) [mg/dL] after 17wks on diet CHOL_fat17	inbred w/CC7	41	both	7-9wks
Paigen2	9912	lipid profile	high-fat diet	total cholesterol (plasma) [mg/dL] fold change CHOL_chg	inbred w/CC7	41	both	7-9wks	(supplemental / summary measure)