MPD: Project measures / variables set: GMC16 ALT

Project measures / variables set: GMC16 ALT

ID, description, units	MPD:56528 ALT alanine transaminase (plasma ALT) [IU/L]
Measures	• age 16-17wks • 20-21wks
Data set, strains	GMC16 inbred w/CC8 8 strains sex: both
Procedure	metabolic panel
Comparison	multiple cohorts measured at two age timepoints
Ontology mappings	VT:0001573 blood alanine transaminase amount MA:0002501 plasma MP:0001573 abnormal circulating alanine transaminase level

Values Means Δ Means Z-scores

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GMC16 - alanine transaminase (plasma ALT)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
age	1	3575.519	3575.519	4.0708	0.0458
sex	1	1447.1961	1447.1961	1.6477	0.2016
strain	4	6996.7811	1749.1953	1.9915	0.0998
age:sex	1	737.0267	737.0267	0.8391	0.3614
age:strain	4	3014.2301	753.5575	0.8579	0.4913
sex:strain	4	15261.3091	3815.3273	4.3438	0.0025
age:sex:strain	4	3606.4493	901.6123	1.0265	0.3963
Residuals	126	110669.4955	878.3293

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
GMC16	56528	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] at age 16-17wks ALT_17	inbred w/CC8	7	both	16-17wks
GMC16	56529	metabolic panel	(none)	alanine transaminase (plasma ALT) [IU/L] at age 20-21wks ALT_21	inbred w/CC8	8	both	20-21wks