MPD: Project measures / variables set: Gould3 EPM_pct

Project measures / variables set: Gould3 EPM_pct_closed

ID, description, units	MPD:47321 EPM_pct_closed withdrawal study group, percentage of time in closed arms [%] nicotine study
Measures	• control • nicotine dose (mg) • 3 • 6.3 • 12
Data set, strains	Gould3 inbred 8 strains sex: m age: 8-12wks
Procedure	elevated plus maze
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0010471 exploratory behavior trait VT:0010716 anxiety-related behavior trait VT:0010721 response to nicotine trait VT:0010722 withdrawal response to addictive substance trait MP:0001362 abnormal anxiety-related response MP:0009774 abnormal behavioral withdrawal response MP:0013189 abnormal exploration in a new environment MP:0020160 abnormal behavioral response to nicotine

Values Means Δ Means Z-scores

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Gould3 - withdrawal study group, percentage of time in closed arms

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	1872.2765	624.0922	1.9571	0.1205
strain	7	62848.7769	8978.3967	28.155	< 0.0001
dose:strain	21	9081.4897	432.4519	1.3561	0.1385
Residuals	302	96305.2743	318.8916

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould3	47321	elevated plus maze	nicotine	withdrawal study group, percentage of time in closed arms [%] control EPM_pct_closed_0	inbred	8	m	8-12wks
Gould3	47322	elevated plus maze	nicotine	withdrawal study group, percentage of time in closed arms [%] dose: 3 mg EPM_pct_closed_3	inbred	8	m	8-12wks
Gould3	47323	elevated plus maze	nicotine	withdrawal study group, percentage of time in closed arms [%] dose: 6.3 mg EPM_pct_closed_6	inbred	8	m	8-12wks
Gould3	47324	elevated plus maze	nicotine	withdrawal study group, percentage of time in closed arms [%] dose: 12 mg EPM_pct_closed_12	inbred	8	m	8-12wks