Project measures / variables set:   Thomsen1   activ_cocaine2

ID, description, units MPD:40707   activ_cocaine2   total activity, test 2, 3h test   [n]  
cocaine study
Measures
• baseline    • dose mg/kg i.p.:    • 3    • 10    • 32
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
Comparisonrepeated measures, baseline then treated multiple doses, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES


  OVERLAPPING STRAIN CURVES
Data
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Thomsen1 - total activity, test 2, 3h test
Created with Highcharts 6.0.7measureChart context menuFemale129S1/SvImJ129S6/SvEvTac129X1/SvJA/JBALB/cByJBALB/cJC3H/HeJC57BL/6JCAST/EiJCrl:CD-1(ICR)DBA/2JFVB/NJSJL/JSPRET/EiJTac:SWbaselinedose 3 mg/kgdose 10 mg/kgdose 32 mg/kg-2.5k02.5k5k7.5k10k12.5k15k17.5k
n

Created with Highcharts 6.0.7measureChart context menuMale129S1/SvImJ129S6/SvEvTac129X1/SvJA/JBALB/cByJBALB/cJC3H/HeJC57BL/6JCAST/EiJCrl:CD-1(ICR)DBA/2JFVB/NJSJL/JSPRET/EiJTac:SWbaselinedose 3 mg/kgdose 10 mg/kgdose 32 mg/kg-2.5k02.5k5k7.5k10k12.5k15k
n


  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   sex 1 49719199.432 49719199.432 4.1815 0.0422
between   strain 14 5545869624.3091 396133544.5935 33.3158 < 0.0001
between   sex:strain 14 459863717.6634 32847408.4045 2.7625 0.0009
between   Residuals 200 2378050806.8824 11890254.0344
within   dose 3 857769311.6609 285923103.887 157.128 < 0.0001
within   dose:sex 3 23160331.4139 7720110.4713 4.2426 0.0056
within   dose:strain 42 424052721.3645 10096493.3658 5.5485 < 0.0001
within   dose:sex:strain 42 105085014.0206 2502024.1433 1.375 0.0617
within   Residuals 600 1091809386.5402 1819682.3109

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDTreatmentMeasure / Variable Description PanelStrains
tested		SexAge
Thomsen1 40707 open field test cocaine total activity, test 2, 3h test   [n]   baseline  activ_cocaine2_0 inbred 15 both 8-10wks
Thomsen1 40708 open field test cocaine total activity, test 2, 3h test   [n]   dose 3 mg/kg  activ_cocaine2_3 inbred 15 both 8-10wks
Thomsen1 40709 open field test cocaine total activity, test 2, 3h test   [n]   dose 10 mg/kg  activ_cocaine2_10 inbred 15 both 8-10wks
Thomsen1 40710 open field test cocaine total activity, test 2, 3h test   [n]   dose 32 mg/kg  activ_cocaine2_32 inbred 15 both 8-10wks



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