MPD: Project measures / variables set: Thomsen1 activ

Project measures / variables set: Thomsen1 activ_cocaine2

ID, description, units	MPD:40707 activ_cocaine2 total activity, test 2, 3h test [n] cocaine study
Measures	• baseline • dose mg/kg i.p.: • 3 • 10 • 32
Data set, strains	Thomsen1 inbred 15 strains sex: both age: 8-10wks
Procedure	open field test
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001392 locomotor behavior trait VT:0010716 anxiety-related behavior trait VT:0010718 response to cocaine trait MP:0001362 abnormal anxiety-related response MP:0001392 abnormal locomotor behavior MP:0020158 abnormal behavioral response to cocaine

Values Means Δ Means Z-scores

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Thomsen1 - total activity, test 2, 3h test

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	49719199.432	49719199.432	4.1815	0.0422
between strain	14	5545869624.3091	396133544.5935	33.3158	< 0.0001
between sex:strain	14	459863717.6634	32847408.4045	2.7625	0.0009
between Residuals	200	2378050806.8824	11890254.0344
within dose	3	857769311.6609	285923103.887	157.128	< 0.0001
within dose:sex	3	23160331.4139	7720110.4713	4.2426	0.0056
within dose:strain	42	424052721.3645	10096493.3658	5.5485	< 0.0001
within dose:sex:strain	42	105085014.0206	2502024.1433	1.375	0.0617
within Residuals	600	1091809386.5402	1819682.3109

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Thomsen1	40707	open field test	cocaine	total activity, test 2, 3h test [n] baseline activ_cocaine2_0	inbred	15	both	8-10wks
Thomsen1	40708	open field test	cocaine	total activity, test 2, 3h test [n] dose 3 mg/kg activ_cocaine2_3	inbred	15	both	8-10wks
Thomsen1	40709	open field test	cocaine	total activity, test 2, 3h test [n] dose 10 mg/kg activ_cocaine2_10	inbred	15	both	8-10wks
Thomsen1	40710	open field test	cocaine	total activity, test 2, 3h test [n] dose 32 mg/kg activ_cocaine2_32	inbred	15	both	8-10wks