MPD: Project measures / variables set: Threadgill2 APAP300

Project measures / variables set: Threadgill2 APAP300

ID, description, units	MPD:39632 APAP300 serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] acetaminophen study
Measures	• baseline • 0.5h • 1h • 2h • 3h • 6h
Data set, strains	Threadgill2 inbred 5 strains sex: m age: 6-8wks
Procedure	drug and metabolite quantification
Comparison	timecourse, same cohort
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0012691 abnormal acetaminophen metabolism

Values Means Δ Means Z-scores

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Threadgill2 - serum acetaminophen (APAP), 300 mg/mL dose acetaminophen

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between strain	4	25351.8664	6337.9666	7.1216	0.0013
between Residuals	18	16019.2425	889.9579
within group	5	103446.1486	20689.2297	108.4808	< 0.0001
within group:strain	20	14245.5488	712.2774	3.7347	< 0.0001
within Residuals	90	17164.6041	190.7178

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill2	39632	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] baseline APAP300_0	inbred	5	m	6-8wks
Threadgill2	39633	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] 0.5h APAP300_0.5	inbred	5	m	6-8wks
Threadgill2	39634	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] 1h APAP300_1	inbred	5	m	6-8wks
Threadgill2	39635	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] 2h APAP300_2	inbred	5	m	6-8wks
Threadgill2	39636	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] 3h APAP300_3	inbred	5	m	6-8wks
Threadgill2	39637	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 300 mg/mL dose acetaminophen [µg/mL] 6h APAP300_6	inbred	5	m	6-8wks