MPD: Project measures / variables set: Threadgill2 APAP50

Project measures / variables set: Threadgill2 APAP50

ID, description, units	MPD:39609 APAP50 serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] acetaminophen study
Measures	• baseline • 0.5h • 1h • 2h • 3h • 6h
Data set, strains	Threadgill2 inbred 5 strains sex: m age: 6-8wks
Procedure	drug and metabolite quantification
Comparison	timecourse, same cohort
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0012691 abnormal acetaminophen metabolism

Values Means Δ Means Z-scores

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Threadgill2 - serum acetaminophen (APAP), 50 mg/mL dose acetaminophen

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between strain	4	28.0289	7.0072	0.7341	0.5812
between Residuals	17	162.2609	9.5448
within group	5	241.3836	48.2767	14.6187	< 0.0001
within group:strain	20	67.3412	3.3671	1.0196	0.4492
within Residuals	85	280.7039	3.3024

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill2	39609	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] baseline APAP50_0	inbred	5	m	6-8wks
Threadgill2	39610	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] 0.5h APAP50_0.5	inbred	5	m	6-8wks
Threadgill2	39612	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] 1h APAP50_1	inbred	5	m	6-8wks
Threadgill2	39613	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] 2h APAP50_2	inbred	5	m	6-8wks
Threadgill2	39614	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] 3h APAP50_3	inbred	5	m	6-8wks
Threadgill2	39615	drug and metabolite quantification	acetaminophen	serum acetaminophen (APAP), 50 mg/mL dose acetaminophen [µg/mL] 6h APAP50_6	inbred	5	m	6-8wks