MPD: Project measures / variables set: Wiltshire2 fluoxetine

Project measures / variables set: Wiltshire2 fluoxetine

ID, description, units	MPD:38007 fluoxetine drug and metabolite concentration [ng/mL] fluoxetine study
Measures	• fluoxetine • norfluoxetine
Data set, strains	Wiltshire2 inbred 30 strains sex: m age: 10-11wks
Procedure	drug and metabolite quantification
Comparison	control group vs. treated group
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0012692 abnormal fluoxetine metabolism

Values Means Δ Means Z-scores

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Wiltshire2 - drug and metabolite concentration

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	499128.5204	499128.5204	3.1229	0.0777
strain	29	56067533.7493	1933363.2327	12.0965	< 0.0001
group:strain	29	8147029.6602	280932.0572	1.7577	0.0089
Residuals	618	98773825.5863	159828.1967

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Wiltshire2	38007	drug and metabolite quantification	fluoxetine	drug and metabolite concentration [ng/mL] fluoxetine fluoxetine	inbred	30	m	10-11wks
Wiltshire2	38008	drug and metabolite quantification	fluoxetine	drug and metabolite concentration [ng/mL] norfluoxetine norfluoxetine	inbred	30	m	10-11wks