MPD: Project measures / variables set: Berndt2 penh

Project measures / variables set: Berndt2 penh

ID, description, units	MPD:35161 penh enhanced pause methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

SIDE-BY-SIDE STRAIN CURVES

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	112.2538	112.2538	25.3969	< 0.0001
between strain	28	2302.9114	82.2468	18.608	< 0.0001
between sex:strain	28	499.6404	17.8443	4.0372	< 0.0001
between Residuals	412	1821.0304	4.42
within group	3	6966.5807	2322.1936	954.2126	< 0.0001
within group:sex	3	120.9484	40.3161	16.5663	< 0.0001
within group:strain	84	2801.7108	33.3537	13.7054	< 0.0001
within group:sex:strain	84	777.1579	9.2519	3.8017	< 0.0001
within Residuals	1236	3007.9579	2.4336

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

	Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
	Berndt2	35161	plethysmography	methacholine	enhanced pause saline penh_saline	inbred	29	both	9-12wks
	Berndt2	35162	plethysmography	methacholine	enhanced pause 5 MCh penh_mch5	inbred	29	both	9-12wks
	Berndt2	35163	plethysmography	methacholine	enhanced pause 10 MCh penh_mch10	inbred	29	both	9-12wks
	Berndt2	35164	plethysmography	methacholine	enhanced pause 20 MCh penh_mch20	inbred	29	both	9-12wks
	Berndt2	35165	plethysmography	methacholine	enhanced pause response index penh_slope	inbred	29	both	9-12wks	(supplemental / summary measure)