MPD: Project measures / variables set: Berndt2 insp

Project measures / variables set: Berndt2 insp_flow

ID, description, units	MPD:35141 insp_flow inspiratory flow rate [mL/kg/s] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - inspiratory flow rate

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	21.2361	21.2361	29.999	< 0.0001
between strain	28	641.9374	22.9263	32.3867	< 0.0001
between sex:strain	28	42.6536	1.5233	2.1519	0.0007
between Residuals	412	291.6522	0.7079
within group	3	920.3597	306.7866	916.5177	< 0.0001
within group:sex	3	1.0958	0.3653	1.0913	0.3517
within group:strain	84	242.6642	2.8889	8.6304	< 0.0001
within group:sex:strain	84	42.0164	0.5002	1.4943	0.0033
within Residuals	1236	413.7271	0.3347

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35141	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] saline insp_flow_saline	inbred	29	both	9-12wks
Berndt2	35142	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] 5 MCh insp_flow_mch5	inbred	29	both	9-12wks
Berndt2	35143	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] 10 MCh insp_flow_mch10	inbred	29	both	9-12wks
Berndt2	35144	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] 20 MCh insp_flow_mch20	inbred	29	both	9-12wks
Berndt2	35145	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] response index insp_flow_slope	inbred	29	both	9-12wks	(supplemental / summary measure)