MPD: Project measures / variables set: Berndt2 min

Project measures / variables set: Berndt2 min_vent

ID, description, units	MPD:35101 min_vent minute ventilation [mL/min] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - minute ventilation

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	20056.8554	20056.8554	35.4598	< 0.0001
between strain	28	458936.3894	16390.5853	28.978	< 0.0001
between sex:strain	28	28150.3951	1005.3713	1.7775	0.0096
between Residuals	412	233036.1805	565.6218
within group	3	58535.0881	19511.696	85.3183	< 0.0001
within group:sex	3	1632.99	544.33	2.3802	0.0681
within group:strain	84	159307.2205	1896.5145	8.2928	< 0.0001
within group:sex:strain	84	27681.1555	329.5376	1.441	0.0069
within Residuals	1236	282664.4035	228.6929

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35101	plethysmography	methacholine	minute ventilation [mL/min] saline min_vent_saline	inbred	29	both	9-12wks
Berndt2	35102	plethysmography	methacholine	minute ventilation [mL/min] 5 MCh min_vent_mch5	inbred	29	both	9-12wks
Berndt2	35103	plethysmography	methacholine	minute ventilation [mL/min] 10 MCh min_vent_mch10	inbred	29	both	9-12wks
Berndt2	35104	plethysmography	methacholine	minute ventilation [mL/min] 20 MCh min_vent_mch20	inbred	29	both	9-12wks
Berndt2	35105	plethysmography	methacholine	minute ventilation [mL/min] response index min_vent_slope	inbred	29	both	9-12wks	(supplemental / summary measure)