MPD: Project measures / variables set: Threadgill1 BUN

Project measures / variables set: Threadgill1 BUN

ID, description, units	MPD:19412 BUN blood urea nitrogen (serum BUN) [mg/dL] acetaminophen study
Measures	• dose (mg/kg) control • 100 • 200 • 300
Data set, strains	Threadgill1 inbred w/CC7 37 strains sex: m age: 8-17wks
Procedure	metabolic panel
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0005265 blood urea nitrogen amount VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0005265 abnormal blood urea nitrogen level MP:0008872 abnormal physiological response to xenobiotic

SIDE-BY-SIDE STRAIN CURVES

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	7855.2849	2618.4283	5.9588	0.0017
strain	4	8957.0145	2239.2536	5.0959	0.0019
dose:strain	12	13410.3316	1117.5276	2.5432	0.0124
Residuals	43	18895.0833	439.4205

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

	Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
	Threadgill1	19412	metabolic panel	acetaminophen	blood urea nitrogen (serum BUN) [mg/dL] control BUN_ctrl	inbred w/CC7	36	m	8-17wks
	Threadgill1	19413	metabolic panel	acetaminophen	blood urea nitrogen (serum BUN) [mg/dL] dose: 100 mg/kg BUN_Rx100	inbred w/CC7	7	m	8-17wks
	Threadgill1	19443	metabolic panel	acetaminophen	blood urea nitrogen (serum BUN) [mg/dL] dose: 200 mg/kg BUN_Rx200	inbred w/CC7	8	m	8-17wks
	Threadgill1	19473	metabolic panel	acetaminophen	blood urea nitrogen (serum BUN) [mg/dL] dose: 300 mg/kg BUN_Rx300	inbred w/CC7	37	m	8-17wks