MPD: Project measures / variables set: Threadgill1 liver

Project measures / variables set: Threadgill1 liver_necrosis

ID, description, units	MPD:19404 liver_necrosis necrosis [%] acetaminophen study
Measures	• dose (mg/kg): control • 100 • 200 • 300
Data set, strains	Threadgill1 inbred w/CC7 37 strains sex: m age: 8-17wks
Procedure	histopathology
Comparison	control group vs. multiple treatment / dosage groups
Ontology mappings	VT:0000598 liver morphology trait VT:0010487 response to xenobiotic stimulus trait MA:0000358 liver MP:0001654 hepatic necrosis MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

Graph Type Points Bars

Dimensions Width: × Height: px

Plot Options Hide Error Bars Strains on X-axis

Strains

measured value [%]

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
dose	3	39853.3613	13284.4538	38.0802	< 0.0001
strain	5	16390.5599	3278.112	9.3968	< 0.0001
dose:strain	15	21517.2393	1434.4826	4.112	< 0.0001
Residuals	58	20233.5833	348.8549

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill1	19404	histopathology	acetaminophen	necrosis [%] control liver_necrosis_ctrl	inbred w/CC7	37	m	8-17wks
Threadgill1	19405	histopathology	acetaminophen	necrosis [%] dose: 100 mg/kg liver_necrosis_Rx100	inbred w/CC7	6	m	8-17wks
Threadgill1	19435	histopathology	acetaminophen	necrosis [%] dose: 200 mg/kg liver_necrosis_Rx200	inbred w/CC7	7	m	8-17wks
Threadgill1	19465	histopathology	acetaminophen	necrosis [%] dose: 300 mg/kg liver_necrosis_Rx300	inbred w/CC7	37	m	8-17wks