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Project measure / variable:   GMC05   PPI_69

ID, description, units MPD:55432   PPI_69   percent prepulse inhibition (PPI), 110 db sound pressure level   [%]  with 69 dB prepulse stimulus  
Data set, strains GMC05   inbred w/CC8   8 strains     sex: both     age: 9-10wks
Procedure acoustic startle test
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  STRAIN COMPARISON PLOT
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GMC05 - percent prepulse inhibition (PPI), 110 db sound pressure level with 69 dB prepulse stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means35.7   % 32.7   %
Median of the strain means38.0   % 33.5   %
SD of the strain means± 24.8 ± 21.6
Coefficient of variation (CV)0.694 0.659
Min–max range of strain means-7.73   –   76.8   % -3.76   –   62.4   %
Mean sample size per strain17.5   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 733.0038 733.0038 1.7447 0.1877
strain 7 117862.9048 16837.5578 40.0763 < 0.0001
sex:strain 7 4305.2773 615.0396 1.4639 0.1804
Residuals 261 109655.8267 420.1373


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 76.8 12.7   16 3.18 0.165 50.9, 91.0 1.66
129S1/SvImJ m 62.4 12.5   16 3.12 0.2 38.9, 89.6 1.38
A/J f -7.73 34.3   16 8.58 -4.44 -70.4, 43.9 -1.75
A/J m -3.76 28.7   16 7.17 -7.63 -59.2, 39.7 -1.69
C57BL/6J f 50.9 11.3   16 2.82 0.222 34.4, 70.3 0.61
C57BL/6J m 53.4 12.1   16 3.03 0.227 35.1, 75.8 0.96
CAST/EiJ f 41.8 17.2   19 3.93 0.411 -2.3, 62.3 0.25
CAST/EiJ m 41.8 16.4   18 3.87 0.393 3.9, 66.0 0.42
NOD/ShiLtJ f 36.2 21.0   18 4.94 0.579 -1.8, 74.5 0.02
NOD/ShiLtJ m 20.0 20.0   16 5.0 1.0 -12.2, 58.1 -0.59
NZO/HlLtJ f 15.0 20.0   17 4.85 1.33 -18.8, 43.7 -0.84
NZO/HlLtJ m 18.9 25.9   17 6.28 1.37 -18.5, 57.8 -0.64
PWK/PhJ f 32.8 22.3   20 5.0 0.681 -18.7, 64.5 -0.12
PWK/PhJ m 25.1 16.2   22 3.46 0.646 -10.8, 56.8 -0.35
WSB/EiJ f 39.8 18.9   18 4.45 0.474 1.0, 60.2 0.17
WSB/EiJ m 43.8 24.9   16 6.22 0.568 -25.2, 67.4 0.51


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 76.8312 5.1243 86.9215 66.741
129S1/SvImJ m 62.3688 5.1243 72.459 52.2785
A/J f -7.725 5.1243 2.3653 -17.8153
A/J m -3.7562 5.1243 6.334 -13.8465
C57BL/6J f 50.85 5.1243 60.9403 40.7597
C57BL/6J m 53.4313 5.1243 63.5215 43.341
CAST/EiJ f 41.7789 4.7024 51.0384 32.5195
CAST/EiJ m 41.7611 4.8312 51.2743 32.2479
NOD/ShiLtJ f 36.2 4.8312 45.7132 26.6868
NOD/ShiLtJ m 19.9813 5.1243 30.0715 9.891
NZO/HlLtJ f 14.9941 4.9713 24.7831 5.2051
NZO/HlLtJ m 18.8588 4.9713 28.6478 9.0698
PWK/PhJ f 32.785 4.5833 41.81 23.76
PWK/PhJ m 25.1 4.37 33.705 16.495
WSB/EiJ f 39.7667 4.8312 49.2799 30.2535
WSB/EiJ m 43.8438 5.1243 53.934 33.7535


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 69.6 3.6234 76.7349 62.4651
A/J both -5.7406 3.6234 1.3943 -12.8755
C57BL/6J both 52.1406 3.6234 59.2755 45.0057
CAST/EiJ both 41.77 3.371 48.4078 35.1323
NOD/ShiLtJ both 28.0906 3.5213 35.0245 21.1568
NZO/HlLtJ both 16.9265 3.5152 23.8483 10.0046
PWK/PhJ both 28.9425 3.1664 35.1774 22.7076
WSB/EiJ both 41.8052 3.5213 48.7391 34.8713




  GWAS USING LINEAR MIXED MODELS