Project measure / variable:   Rusyn6   DCA_liver_tce

ID, description, units MPD:51218   DCA_liver_tce   dichloroacetic acid (liver DCA)   [nmol/g]  
trichloroethylene study
Data set, strains Rusyn6   inbred   7 strains     sex: m     age: 6-7wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Rusyn6 - dichloroacetic acid (liver DCA)

NOD/ShiLtJBTBR T<+> Itpr3<tf>/JNZW/LacJA/JC57BL/6J129S1/SvImJCAST/EiJ nmol/g 0.60.81.01.21.41.61.8femalemale


  MEASURE SUMMARY
Measure Summary Male
Number of strains tested7 strains
Mean of the strain means1.14   nmol/g
Median of the strain means1.12   nmol/g
SD of the strain means± 0.350
Coefficient of variation (CV)0.308
Min–max range of strain means0.533   –   1.50   nmol/g
Mean sample size per strain3.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 6 2.4867 0.4144 7.4404 0.0003
Residuals 19 1.0583 0.0557


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Strain
Sex
Mean
SD
N mice
SEM
CV
Min, Max
Z score
129S1/SvImJ m 0.85 0.0577   4 0.0289 0.0679 0.8, 0.9 -0.82
A/J m 1.12 0.395   4 0.197 0.351 0.8, 1.6 -0.05
BTBR T+ Itpr3tf/J m 1.43 0.0577   3 0.0333 0.0403 1.4, 1.5 0.84
C57BL/6J m 1.12 0.263   4 0.131 0.234 0.9, 1.4 -0.05
CAST/EiJ m 0.533 0.0577   3 0.0333 0.108 0.5, 0.6 -1.72
NOD/ShiLtJ m 1.5 0.294   4 0.147 0.196 1.2, 1.9 1.04
NZW/LacJ m 1.4 0.183   4 0.0913 0.13 1.2, 1.6 0.75


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ m 0.85 0.118 1.097 0.603
A/J m 1.125 0.118 1.372 0.878
BTBR T+ Itpr3tf/J m 1.4333 0.1363 1.7185 1.1481
C57BL/6J m 1.125 0.118 1.372 0.878
CAST/EiJ m 0.5333 0.1363 0.8185 0.2481
NOD/ShiLtJ m 1.5 0.118 1.747 1.253
NZW/LacJ m 1.4 0.118 1.647 1.153




  GWAS USING LINEAR MIXED MODELS

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