Project measure / variable:   Thomsen1   activ_cocaine1_3

ID, description, units MPD:40702   activ_cocaine1_3   total activity, test 1, 3h test   [n]  dose 3 mg/kg  
cocaine study
Data set, strains Thomsen1   inbred   15 strains     sex: both     age: 8-10wks
Procedure open field test
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  STRAIN COMPARISON PLOT
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Thomsen1 - total activity, test 1, 3h test dose 3 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested15 strains15 strains
Mean of the strain means2375   n 2185   n
Median of the strain means1058   n 1606   n
SD of the strain means± 2354 ± 1946
Coefficient of variation (CV)0.991 0.891
Min–max range of strain means263   –   6791   n 205   –   6205   n
Mean sample size per strain7.9   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 3716925.3689 3716925.3689 1.5887 0.209
strain 14 900656670.3205 64332619.3086 27.4981 < 0.0001
sex:strain 14 125859960.722 8989997.1944 3.8426 < 0.0001
Residuals 202 472585350.0714 2339531.436


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 458.0 176.0   8 62.3 0.385 286.0, 854.0 -0.81
129S1/SvImJ m 804.0 204.0   8 72.3 0.254 608.0, 1139.0 -0.71
129S6/SvEvTac f 267.0 157.0   8 55.6 0.589 104.0, 606.0 -0.9
129S6/SvEvTac m 372.0 237.0   8 83.7 0.636 62.0, 742.0 -0.93
129X1/SvJ f 263.0 125.0   8 44.1 0.475 143.0, 554.0 -0.9
129X1/SvJ m 205.0 101.0   8 35.7 0.492 100.0, 399.0 -1.02
A/J f 749.0 390.0   8 138.0 0.52 142.0, 1541.0 -0.69
A/J m 999.0 623.0   8 220.0 0.624 202.0, 1845.0 -0.61
BALB/cByJ f 3415.0 1879.0   8 664.0 0.55 854.0, 6099.0 0.44
BALB/cByJ m 6205.0 969.0   8 342.0 0.156 5119.0, 8249.0 2.07
BALB/cJ f 6138.0 1521.0   8 538.0 0.248 4176.0, 8057.0 1.6
BALB/cJ m 3454.0 3042.0   8 1076.0 0.881 989.0, 8912.0 0.65
C3H/HeJ f 723.0 269.0   7 102.0 0.372 343.0, 1053.0 -0.7
C3H/HeJ m 1606.0 840.0   7 318.0 0.523 559.0, 2846.0 -0.3
C57BL/6J f 6151.0 3790.0   8 1340.0 0.616 3754.0, 15202.0 1.6
C57BL/6J m 2374.0 1736.0   8 614.0 0.731 1136.0, 6541.0 0.1
CAST/EiJ f 4083.0 1311.0   8 464.0 0.321 2694.0, 6156.0 0.73
CAST/EiJ m 3695.0 2367.0   4 1183.0 0.641 1302.0, 6880.0 0.78
Crl:CD-1(ICR) f 1870.0 1660.0   8 587.0 0.888 611.0, 5219.0 -0.21
Crl:CD-1(ICR) m 2838.0 3724.0   8 1317.0 1.31 383.0, 10019.0 0.34
DBA/2J f 834.0 812.0   8 287.0 0.974 261.0, 2243.0 -0.65
DBA/2J m 1030.0 739.0   8 261.0 0.718 91.0, 2185.0 -0.59
FVB/NJ f 6791.0 2361.0   8 835.0 0.348 3403.0, 10623.0 1.88
FVB/NJ m 6070.0 1449.0   8 512.0 0.239 4283.0, 8017.0 2.0
SJL/J f 1058.0 856.0   8 303.0 0.809 224.0, 2452.0 -0.56
SJL/J m 622.0 308.0   8 109.0 0.494 376.0, 1345.0 -0.8
SPRET/EiJ f 541.0 439.0   7 166.0 0.812 136.0, 1226.0 -0.78
SPRET/EiJ m 531.0 247.0   7 93.4 0.465 280.0, 840.0 -0.85
Tac:SW f 2286.0 1000.0   8 353.0 0.437 1177.0, 3769.0 -0.04
Tac:SW m 1968.0 1019.0   8 360.0 0.518 904.0, 3317.0 -0.11


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 457.625 540.7785 1523.9199 0.0
129S1/SvImJ m 804.25 540.7785 1870.5449 0.0
129S6/SvEvTac f 266.75 540.7785 1333.0449 0.0
129S6/SvEvTac m 372.25 540.7785 1438.5449 0.0
129X1/SvJ f 263.0 540.7785 1329.2949 0.0
129X1/SvJ m 205.25 540.7785 1271.5449 0.0
A/J f 749.0 540.7785 1815.2949 0.0
A/J m 999.0 540.7785 2065.2949 0.0
BALB/cByJ f 3415.375 540.7785 4481.6699 2349.0801
BALB/cByJ m 6205.25 540.7785 7271.5449 5138.9551
BALB/cJ f 6138.0 540.7785 7204.2949 5071.7051
BALB/cJ m 3454.0 540.7785 4520.2949 2387.7051
C3H/HeJ f 723.4286 578.1166 1863.3458 0.0
C3H/HeJ m 1605.8571 578.1166 2745.7743 465.94
C57BL/6J f 6151.375 540.7785 7217.6699 5085.0801
C57BL/6J m 2374.0 540.7785 3440.2949 1307.7051
CAST/EiJ f 4082.875 540.7785 5149.1699 3016.5801
CAST/EiJ m 3694.75 764.7763 5202.7187 2186.7813
Crl:CD-1(ICR) f 1869.75 540.7785 2936.0449 803.4551
Crl:CD-1(ICR) m 2838.0 540.7785 3904.2949 1771.7051
DBA/2J f 834.0 540.7785 1900.2949 0.0
DBA/2J m 1029.75 540.7785 2096.0449 0.0
FVB/NJ f 6791.0 540.7785 7857.2949 5724.7051
FVB/NJ m 6069.625 540.7785 7135.9199 5003.3301
SJL/J f 1058.0 540.7785 2124.2949 0.0
SJL/J m 622.375 540.7785 1688.6699 0.0
SPRET/EiJ f 541.0 578.1166 1680.9172 0.0
SPRET/EiJ m 531.0 578.1166 1670.9172 0.0
Tac:SW f 2285.5 540.7785 3351.7949 1219.2051
Tac:SW m 1967.5 540.7785 3033.7949 901.2051


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 630.9375 382.3882 1384.9219 0.0
129S6/SvEvTac both 319.5 382.3882 1073.4844 0.0
129X1/SvJ both 234.125 382.3882 988.1094 0.0
A/J both 874.0 382.3882 1627.9844 120.0156
BALB/cByJ both 4810.3125 382.3882 5564.2969 4056.3281
BALB/cJ both 4796.0 382.3882 5549.9844 4042.0156
C3H/HeJ both 1164.6429 408.7902 1970.686 358.5997
C57BL/6J both 4262.6875 382.3882 5016.6719 3508.7031
CAST/EiJ both 3888.8125 468.328 4812.251 2965.374
Crl:CD-1(ICR) both 2353.875 382.3882 3107.8594 1599.8906
DBA/2J both 931.875 382.3882 1685.8594 177.8906
FVB/NJ both 6430.3125 382.3882 7184.2969 5676.3281
SJL/J both 840.1875 382.3882 1594.1719 86.2031
SPRET/EiJ both 536.0 408.7902 1342.0432 0.0
Tac:SW both 2126.5 382.3882 2880.4844 1372.5156




  GWAS USING LINEAR MIXED MODELS