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Project measure / variable:   Threadgill2   APAP_Sulf_50_2

ID, description, units MPD:39619   APAP_Sulf_50_2   serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen   [µg/mL]  2h  
acetaminophen study
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Threadgill2 - serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen 2h



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested5 strains
Mean of the strain means2.02   µg/mL
Median of the strain means2.03   µg/mL
SD of the strain means± 0.561
Coefficient of variation (CV)0.278
Min–max range of strain means1.37   –   2.89   µg/mL
Mean sample size per strain4.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 4 5.8785 1.4696 1.2786 0.3132
Residuals 19 21.8389 1.1494


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
C3H/HeJ m 2.89 1.81   5 0.808 0.625 1.4, 6.0 1.56
C57BL/6J m 1.37 0.871   4 0.435 0.637 0.19, 2.07 -1.15
DBA/2J m 2.05 0.801   5 0.358 0.391 0.73, 2.75 0.06
LP/J m 2.03 0.931   5 0.416 0.459 1.06, 3.03 0.02
NZW/LacJ m 1.74 0.349   5 0.156 0.201 1.36, 2.12 -0.49


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
C3H/HeJ m 2.89 0.4795 3.8935 1.8865
C57BL/6J m 1.3675 0.5361 2.4895 0.2455
DBA/2J m 2.048 0.4795 3.0515 1.0445
LP/J m 2.028 0.4795 3.0315 1.0245
NZW/LacJ m 1.738 0.4795 2.7415 0.7345




  GWAS USING LINEAR MIXED MODELS