Project measure / variable:   Gould1   blood_lithium200

ID, description, units MPD:37405   blood_lithium200   serum lithium concentration   [mmol/L]  dose 200 mg/kg  
lithium study
Data set, strains Gould1   inbred   11 strains     sex: m     age: 7-8wks
Procedure drug and metabolite quantification
Ontology mappings

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  STRAIN COMPARISON PLOT
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Gould1 - serum lithium concentration dose 200 mg/kg



  MEASURE SUMMARY
Measure Summary Male
Number of strains tested11 strains
Mean of the strain means0.695   mmol/L
Median of the strain means0.656   mmol/L
SD of the strain means± 0.160
Coefficient of variation (CV)0.230
Min–max range of strain means0.437   –   0.964   mmol/L
Mean sample size per strain7.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 10 1.8256 0.1826 11.975 < 0.0001
Residuals 72 1.0976 0.0152


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S6/SvEvTac m 0.885 0.15   8 0.0532 0.17 0.75, 1.17 1.18
A/J m 0.964 0.0809   8 0.0286 0.0839 0.81, 1.08 1.68
BALB/cJ m 0.844 0.212   8 0.0751 0.252 0.42, 1.08 0.93
C3H/HeNHsd m 0.776 0.0927   8 0.0328 0.119 0.63, 0.9 0.5
C57BL/6J m 0.641 0.101   8 0.0358 0.158 0.51, 0.78 -0.34
CBA/J m 0.626 0.0588   8 0.0208 0.0939 0.57, 0.75 -0.43
Crl:CD-1(ICR) m 0.503 0.0843   6 0.0344 0.167 0.36, 0.6 -1.2
DBA/2J m 0.656 0.0809   8 0.0286 0.123 0.54, 0.75 -0.25
FVB/NJ m 0.437 0.0427   6 0.0174 0.0979 0.36, 0.48 -1.61
Hsd:NIHS m 0.613 0.207   7 0.0782 0.338 0.24, 0.87 -0.51
NTac:NIHBS m 0.705 0.103   8 0.0363 0.146 0.51, 0.84 0.06


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S6/SvEvTac m 0.885 0.0437 0.972 0.798
A/J m 0.9638 0.0437 1.0508 0.8767
BALB/cJ m 0.8437 0.0437 0.9308 0.7567
C3H/HeNHsd m 0.7763 0.0437 0.8633 0.6892
C57BL/6J m 0.6412 0.0437 0.7283 0.5542
CBA/J m 0.6262 0.0437 0.7133 0.5392
Crl:CD-1(ICR) m 0.5033 0.0504 0.6038 0.4028
DBA/2J m 0.6562 0.0437 0.7433 0.5692
FVB/NJ m 0.4367 0.0504 0.5372 0.3362
Hsd:NIHS m 0.6129 0.0467 0.7059 0.5198
NTac:NIHBS m 0.705 0.0437 0.792 0.618




  GWAS USING LINEAR MIXED MODELS