Project measure / variable:   Shockley1   GLDH

ID, description, units MPD:33404   GLDH   glutamate dehydrogenase (GLDH)   [IU/L]  control diet  
high-fat diet study
Data set, strains Shockley1   inbred   10 strains     sex: both     age: 10-13wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Shockley1 - glutamate dehydrogenase (GLDH) control diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means23.1   IU/L 21.9   IU/L
Median of the strain means16.9   IU/L 19.8   IU/L
SD of the strain means± 14.1 ± 12.1
Coefficient of variation (CV)0.611 0.551
Min–max range of strain means9.68   –   55.1   IU/L 9.20   –   51.0   IU/L
Mean sample size per strain5.0   mice 5.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 54.3026 54.3026 0.2166 0.643
strain 9 10462.0046 1162.445 4.6357 0.0001
sex:strain 9 4971.7181 552.4131 2.2029 0.0303
Residuals 79 19810.1955 250.762


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 31.5 11.3   5 5.06 0.359 19.5, 46.7 0.59
129S1/SvImJ m 27.7 11.1   5 4.98 0.402 14.0, 42.8 0.48
A/J f 55.1 9.12   5 4.08 0.165 44.4, 66.4 2.26
A/J m 20.9 6.46   5 2.89 0.309 13.6, 28.1 -0.08
BALB/cJ f 14.5 1.46   5 0.654 0.101 12.5, 16.2 -0.61
BALB/cJ m 14.0 5.63   5 2.52 0.402 9.4, 22.5 -0.65
C3H/HeJ f 16.3 8.13   5 3.64 0.5 7.7, 27.1 -0.48
C3H/HeJ m 10.0 3.95   5 1.77 0.395 5.4, 15.1 -0.99
C57BL/6J f 9.68 3.32   5 1.49 0.343 6.8, 13.6 -0.95
C57BL/6J m 9.2 3.76   5 1.68 0.409 5.7, 13.6 -1.05
DBA/2J f 17.5 7.28   5 3.26 0.415 10.1, 25.3 -0.4
DBA/2J m 18.7 8.2   5 3.67 0.438 9.7, 29.7 -0.26
I/LnJ f 12.0 2.59   4 1.3 0.216 9.3, 15.1 -0.79
I/LnJ m 22.6 5.72   5 2.56 0.253 13.4, 27.5 0.06
MRL/MpJ-Faslpr/J f 35.1 19.0   5 8.5 0.541 18.4, 65.6 0.85
MRL/MpJ-Faslpr/J m 27.4 6.9   5 3.09 0.252 19.5, 34.4 0.46
NZB/BlNJ f 26.4 8.96   5 4.01 0.34 11.3, 34.6 0.23
NZB/BlNJ m 51.0 61.0   5 27.3 1.2 21.9, 160.0 2.41
SM/J f 13.3 5.3   5 2.37 0.399 8.2, 19.5 -0.7
SM/J m 17.3 6.6   5 2.95 0.383 8.1, 23.7 -0.38


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 31.48 7.0818 45.576 17.384
129S1/SvImJ m 27.68 7.0818 41.776 13.584
A/J f 55.14 7.0818 69.236 41.044
A/J m 20.94 7.0818 35.036 6.844
BALB/cJ f 14.48 7.0818 28.576 0.384
BALB/cJ m 14.02 7.0818 28.116 0.0
C3H/HeJ f 16.28 7.0818 30.376 2.184
C3H/HeJ m 10.0 7.0818 24.096 0.0
C57BL/6J f 9.68 7.0818 23.776 0.0
C57BL/6J m 9.2 7.0818 23.296 0.0
DBA/2J f 17.54 7.0818 31.636 3.444
DBA/2J m 18.74 7.0818 32.836 4.644
I/LnJ f 11.975 7.9177 27.7349 0.0
I/LnJ m 22.64 7.0818 36.736 8.544
MRL/MpJ-Faslpr/J f 35.12 7.0818 49.216 21.024
MRL/MpJ-Faslpr/J m 27.36 7.0818 41.456 13.264
NZB/BlNJ f 26.4 7.0818 40.496 12.304
NZB/BlNJ m 51.0 7.0818 65.096 36.904
SM/J f 13.28 7.0818 27.376 0.0
SM/J m 17.26 7.0818 31.356 3.164


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 29.58 5.0076 39.5474 19.6126
A/J both 38.04 5.0076 48.0074 28.0726
BALB/cJ both 14.25 5.0076 24.2174 4.2826
C3H/HeJ both 13.14 5.0076 23.1074 3.1726
C57BL/6J both 9.44 5.0076 19.4074 0.0
DBA/2J both 18.14 5.0076 28.1074 8.1726
I/LnJ both 17.3075 5.3114 27.8795 6.7355
MRL/MpJ-Faslpr/J both 31.24 5.0076 41.2074 21.2726
NZB/BlNJ both 38.7 5.0076 48.6674 28.7326
SM/J both 15.27 5.0076 25.2374 5.3026




  GWAS USING LINEAR MIXED MODELS