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Project measure / variable:   Shockley1   BUN

ID, description, units MPD:33402   BUN   blood urea nitrogen (BUN)   [mg/dL]  control diet  
high-fat diet study
Data set, strains Shockley1   inbred   10 strains     sex: both     age: 10-13wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Shockley1 - blood urea nitrogen (BUN) control diet



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means16.8   mg/dL 20.1   mg/dL
Median of the strain means15.2   mg/dL 19.0   mg/dL
SD of the strain means± 3.24 ± 2.81
Coefficient of variation (CV)0.192 0.140
Min–max range of strain means14.2   –   22.8   mg/dL 17.0   –   24.6   mg/dL
Mean sample size per strain4.6   mice 5.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 261.1957 261.1957 57.3852 < 0.0001
strain 9 693.971 77.1079 16.9408 < 0.0001
sex:strain 9 90.0188 10.0021 2.1975 0.0319
Residuals 72 327.7167 4.5516


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 18.2 3.11   5 1.39 0.171 15.0, 23.0 0.42
129S1/SvImJ m 22.6 2.07   5 0.927 0.0918 21.0, 26.0 0.89
A/J f 14.8 2.68   5 1.2 0.181 12.0, 19.0 -0.63
A/J m 17.0 1.58   5 0.707 0.093 15.0, 19.0 -1.1
BALB/cJ f 14.6 0.548   5 0.245 0.0375 14.0, 15.0 -0.69
BALB/cJ m 17.0 2.35   5 1.05 0.138 15.0, 20.0 -1.1
C3H/HeJ f 14.4 2.19   5 0.98 0.152 13.0, 18.0 -0.75
C3H/HeJ m 19.2 1.3   5 0.583 0.0679 17.0, 20.0 -0.32
C57BL/6J f 22.8 1.92   5 0.86 0.0844 21.0, 26.0 1.84
C57BL/6J m 24.6 1.14   5 0.51 0.0463 23.0, 26.0 1.61
DBA/2J f 14.4 1.95   5 0.872 0.135 12.0, 17.0 -0.75
DBA/2J m 18.7 2.08   3 1.2 0.112 17.0, 21.0 -0.5
I/LnJ f 14.2 0.957   4 0.479 0.0672 13.0, 15.0 -0.82
I/LnJ m 18.8 2.28   5 1.02 0.121 16.0, 21.0 -0.46
MRL/MpJ-Faslpr/J f 17.5 0.707   2   0.5 0.0404 17.0, 18.0 0.2
MRL/MpJ-Faslpr/J m 24.2 4.44   5 1.98 0.183 20.0, 31.0 1.46
NZB/BlNJ f 15.5 1.73   4 0.866 0.112 13.0, 17.0 -0.41
NZB/BlNJ m 18.2 1.79   5 0.8 0.0983 16.0, 21.0 -0.67
SM/J f 22.0 1.41   4 0.707 0.0643 20.0, 23.0 1.59
SM/J m 20.6 1.52   5 0.678 0.0736 19.0, 22.0 0.18


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 18.2 0.9541 20.102 16.298
129S1/SvImJ m 22.6 0.9541 24.502 20.698
A/J f 14.8 0.9541 16.702 12.898
A/J m 17.0 0.9541 18.902 15.098
BALB/cJ f 14.6 0.9541 16.502 12.698
BALB/cJ m 17.0 0.9541 18.902 15.098
C3H/HeJ f 14.4 0.9541 16.302 12.498
C3H/HeJ m 19.2 0.9541 21.102 17.298
C57BL/6J f 22.8 0.9541 24.702 20.898
C57BL/6J m 24.6 0.9541 26.502 22.698
DBA/2J f 14.4 0.9541 16.302 12.498
DBA/2J m 18.6667 1.2317 21.1221 16.2112
I/LnJ f 14.25 1.0667 16.3765 12.1235
I/LnJ m 18.8 0.9541 20.702 16.898
MRL/MpJ-Faslpr/J f 17.5 1.5086 20.5073 14.4927
MRL/MpJ-Faslpr/J m 24.2 0.9541 26.102 22.298
NZB/BlNJ f 15.5 1.0667 17.6265 13.3735
NZB/BlNJ m 18.2 0.9541 20.102 16.298
SM/J f 22.0 1.0667 24.1265 19.8735
SM/J m 20.6 0.9541 22.502 18.698


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 20.4 0.6747 21.7449 19.0551
A/J both 15.9 0.6747 17.2449 14.5551
BALB/cJ both 15.8 0.6747 17.1449 14.4551
C3H/HeJ both 16.8 0.6747 18.1449 15.4551
C57BL/6J both 23.7 0.6747 25.0449 22.3551
DBA/2J both 16.5333 0.779 18.0863 14.9804
I/LnJ both 16.525 0.7156 17.9515 15.0985
MRL/MpJ-Faslpr/J both 20.85 0.8925 22.6291 19.0709
NZB/BlNJ both 16.85 0.7156 18.2765 15.4235
SM/J both 21.3 0.7156 22.7265 19.8735




  GWAS USING LINEAR MIXED MODELS