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Project measure / variable:   Auwerx2   LDH_HFD

ID, description, units MPD:114680   LDH_HFD   plasma lactate dehydrogenase amount (LDH)   [U/L]  HFD  
Data set, strains Auwerx2   inbred w/CC8   9 strains     sex: both     age: 21wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Auwerx2 - plasma lactate dehydrogenase amount (LDH) HFD



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means369.0   U/L 342.0   U/L
Median of the strain means335.4   U/L 261.0   U/L
SD of the strain means± 196.0 ± 233.7
Coefficient of variation (CV)0.5312 0.6834
Min–max range of strain means159.0   –   817.8   U/L 191.4   –   945.0   U/L
Mean sample size per strain4.9   mice 3.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1378.2332 1378.2332 0.0077 0.9304
strain 7 1197808.4141 171115.4877 0.9543 0.4732
sex:strain 7 2067955.5055 295422.2151 1.6476 0.1412
Residuals 56 10041068.5 179304.7946


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 298.2 123.5   5 55.23 0.4141 178.0, 491.0 -0.36
129S1/SvImJ m 252.5 61.52   2   43.5 0.2436 209.0, 296.0 -0.38
A/J f 394.8 93.37   4 46.686 0.2365 330.0, 528.0 0.13
A/J m 278.6 47.987   5 21.461 0.1722 218.0, 350.0 -0.27
C57BL/6J f 489.0 190.4   3 109.9 0.3893 306.0, 686.0 0.61
C57BL/6J m 331.0 108.8   4 54.39 0.3286 243.0, 479.0 -0.05
CAST/EiJ f 273.2 37.191   5 16.632 0.1361 224.0, 312.0 -0.49
CAST/EiJ m 261.0 53.74   2   38.0 0.2059 223.0, 299.0 -0.35
DBA/2J f 191.8 36.609   5 16.372 0.1909 156.0, 236.0 -0.9
DBA/2J m 191.4 44.59   5 19.941 0.233 153.0, 258.0 -0.64
NOD/ShiLtJ f 361.7 129.5   10 40.948 0.358 187.0, 571.0 -0.04
NOD/ShiLtJ m 379.2 156.6   5 70.04 0.413 286.0, 655.0 0.16
NZO/HlLtJ f 335.4 225.8   5 101.0 0.6731 149.0, 649.0 -0.17
NZO/HlLtJ m 238.0 0.0   1   0.0 0.0 238.0, 238.0 -0.44
PWK/PhJ f 817.8 477.4   4 238.7 0.5838 282.0, 1443.0 2.29
PWK/PhJ m 201.2 25.84   5 11.556 0.1284 183.0, 242.0 -0.6
WSB/EiJ f 159.0 82.53   3 47.648 0.519 85.0, 248.0 -1.07
WSB/EiJ m 945.0 1488.0   5 665.7 1.5751 197.0, 3606.0 2.58


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 298.2 189.3698997427 677.5534940888 -81.1534940888
129S1/SvImJ m 252.5 299.4201017324 852.3105398319 -347.3105398319
A/J f 394.75 211.7219843585 818.8801001423 -29.3801001423
A/J m 278.6 189.3698997427 657.9534940888 -100.7534940888
C57BL/6J f 489.0 244.4754893255 978.7432549771 -0.7432549771
C57BL/6J m 331.0 211.7219843585 755.1301001423 -93.1301001423
CAST/EiJ f 273.2 189.3698997427 652.5534940888 -106.1534940888
CAST/EiJ m 261.0 299.4201017324 860.8105398319 -338.8105398319
DBA/2J f 191.8 189.3698997427 571.1534940888 -187.5534940888
DBA/2J m 191.4 189.3698997427 570.7534940888 -187.9534940888
NOD/ShiLtJ f 361.7 133.9047402607 629.943428137 93.456571863
NOD/ShiLtJ m 379.2 189.3698997427 758.5534940888 -0.1534940888
PWK/PhJ f 817.75 211.7219843585 1241.8801001423 393.6198998577
PWK/PhJ m 201.2 189.3698997427 580.5534940888 -178.1534940888
WSB/EiJ f 159.0 244.4754893255 648.7432549771 -330.7432549771
WSB/EiJ m 945.0 189.3698997427 1324.3534940888 565.6465059112


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 275.35 177.1393210513 630.2027008389 -79.5027008389
A/J both 336.675 142.027424807 621.1901205666 52.1598794334
C57BL/6J both 410.0 161.7053366015 733.9347147352 86.0652852648
CAST/EiJ both 267.1 177.1393210513 621.9527008389 -87.7527008389
DBA/2J both 191.6 133.9047402607 459.843428137 -76.643428137
NOD/ShiLtJ both 370.45 115.9649067529 602.7556231649 138.1443768351
PWK/PhJ both 509.475 142.027424807 793.9901205666 224.9598794334
WSB/EiJ both 552.0 154.6198756706 861.7408308865 242.2591691135




  GWAS USING LINEAR MIXED MODELS