Project measure / variable:   CSNA03   extinction_active_cc_s3

ID, description, units MPD:110402   extinction_active_cc_s3   extinction, active lever presses (intravenous self administration), CC   [n]  session 3  
cocaine study
Data set, strains CSNA03   CC w/par   54 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - extinction, active lever presses (intravenous self administration), CC session 3



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested52 strains50 strains
Mean of the strain means189.9   n 83.27   n
Median of the strain means64.96   n 56.25   n
SD of the strain means± 415.4 ± 86.6
Coefficient of variation (CV)2.1876 1.04
Min–max range of strain means0.0   –   2695.0   n 0.0   –   414.0   n
Mean sample size per strain3.0   mice 3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 234303.0327 234303.0327 3.7811 0.0531
strain 34 4466244.7899 131360.1409 2.1199 0.0007
sex:strain 34 3322573.0583 97722.737 1.577 0.0284
Residuals 220 13632580.3639 61966.2744


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 17.75 23.975   8 8.4763 1.3507 -0.41
A/J m 17.286 19.19   7 7.253 1.1101 -0.76
C57BL/6J f 226.5 281.2   11 84.79 1.2413 19.0, 1005.0 0.09
C57BL/6J m 42.462 28.445   13 7.8891 0.6699 5.0, 104.0 -0.47
CAST/EiJ f 94.0 0.0   1   0.0 0.0 94.0, 94.0 -0.23
CAST/EiJ m 44.0 2.8284   2   2.0 0.0643 42.0, 46.0 -0.45
CC001/UncJ f 55.0 10.817   3 6.245 0.1967 46.0, 67.0 -0.32
CC001/UncJ m 414.0 644.7   4 322.3 1.5572 21.0, 1378.0 3.82
CC002/UncJ f 2695.0 3658.0   3 2112.0 1.3574 32.0, 6866.0 6.03
CC002/UncJ m 35.0 0.0   1   0.0 0.0 35.0, 35.0 -0.56
CC003/UncJ f 33.0 15.556   2   11.0 0.4714 22.0, 44.0 -0.38
CC003/UncJ m 22.333 2.0817   3 1.2019 0.0932 20.0, 24.0 -0.7
CC004/TauUncJ f 199.3 155.7   9 51.9 0.7811 0.02
CC004/TauUncJ m 291.3 229.1   19 52.57 0.7867 53.0, 951.0 2.4
CC005/TauUncJ f 66.25 117.3   4 58.64 1.7703 4.0, 242.0 -0.3
CC005/TauUncJ m 31.5 2.1213   2   1.5 0.0673 30.0, 33.0 -0.6
CC006/TauUncJ f 323.0 0.0   1   0.0 0.0 323.0, 323.0 0.32
CC006/TauUncJ m 201.5 285.0   2   201.5 1.4142 1.37
CC007/UncJ f 46.0 59.4   2   42.0 1.2912 4.0, 88.0 -0.35
CC007/UncJ m 70.67 100.2   3 57.85 1.4179 5.0, 186.0 -0.15
CC008/GeniUncJ f 2.5 3.5355   2   2.5 1.4142 -0.45
CC008/GeniUncJ m 103.0 24.042   2   17.0 0.2334 86.0, 120.0 0.23
CC009/UncJ f 63.33 78.44   3 45.286 1.2385 3.0, 152.0 -0.3
CC009/UncJ m 30.667 31.533   3 18.206 1.0283 -0.61
CC011/UncJ f 202.7 214.0   3 123.5 1.0557 44.0, 446.0 0.03
CC011/UncJ m 102.0 91.92   2   65.0 0.9012 37.0, 167.0 0.22
CC012/GeniUncJ f 107.0 0.0   1   0.0 0.0 107.0, 107.0 -0.2
CC012/GeniUncJ m 66.0 34.598   3 19.975 0.5242 33.0, 102.0 -0.2
CC013/GeniUncJ f 155.7 113.5   3 65.51 0.7289 28.0, 245.0 -0.08
CC013/GeniUncJ m 92.0 27.731   3 16.01 0.3014 60.0, 109.0 0.1
CC015/UncJ f 29.0 0.0   1   0.0 0.0 29.0, 29.0 -0.39
CC015/UncJ m 38.0 0.0   1   0.0 0.0 38.0, 38.0 -0.52
CC016/GeniUncJ f 873.0 1219.0   2   862.0 1.3964 11.0, 1735.0 1.64
CC016/GeniUncJ m 25.0 26.87   2   19.0 1.0748 6.0, 44.0 -0.67
CC017/UncJ f 9.0 1.0   3 0.57735 0.1111 8.0, 10.0 -0.44
CC017/UncJ m 6.25 3.6856   4 1.8428 0.5897 2.0, 11.0 -0.89
CC018/UncJ f 211.0 150.4   3 86.85 0.7129 38.0, 311.0 0.05
CC018/UncJ m 187.6 146.9   5 65.69 0.783 83.0, 439.0 1.2
CC019/TauUncJ f 187.8 179.6   5 80.34 0.9565 29.0, 488.0 -0.01
CC019/TauUncJ m 44.0 9.8995   2   7.0 0.225 37.0, 51.0 -0.45
CC020/GeniUncJ f 89.0 0.0   1   0.0 0.0 89.0, 89.0 -0.24
CC023/GeniUncJ f 52.67 42.336   3 24.443 0.8038 4.0, 81.0 -0.33
CC023/GeniUncJ m 77.67 105.2   3 60.74 1.3545 12.0, 199.0 -0.06
CC024/GeniUncJ f 57.5 81.32   2   57.5 1.4142 -0.32
CC024/GeniUncJ m 9.0 0.0   1   0.0 0.0 9.0, 9.0 -0.86
CC025/GeniUncJ f 35.5 50.2   2   35.5 1.4142 -0.37
CC026/GeniUncJ f 22.6 12.422   5 5.5552 0.5496 5.0, 39.0 -0.4
CC026/GeniUncJ m 26.333 11.846   3 6.8394 0.4499 19.0, 40.0 -0.66
CC027/GeniUncJ f 590.7 912.3   3 526.7 1.5445 8.0, 1642.0 0.96
CC027/GeniUncJ m 83.0 133.7   4 66.84 1.6107 3.0, 283.0 0.0
CC028/GeniUncJ f 109.2 61.95   4 30.977 0.5671 48.0, 192.0 -0.19
CC028/GeniUncJ m 72.0 42.03   5 18.796 0.5837 21.0, 115.0 -0.13
CC029/UncJ f 1.0 0.0   1   0.0 0.0 1.0, 1.0 -0.45
CC029/UncJ m 13.0 0.0   1   0.0 0.0 13.0, 13.0 -0.81
CC030/GeniUncJ f 245.0 157.0   2   111.0 0.6407 134.0, 356.0 0.13
CC030/GeniUncJ m 55.5 40.305   2   28.5 0.7262 27.0, 84.0 -0.32
CC032/GeniUncJ f 63.67 24.132   3 13.932 0.379 37.0, 84.0 -0.3
CC032/GeniUncJ m 183.8 237.3   4 118.7 1.2916 12.0, 526.0 1.16
CC033/GeniUncJ f 21.0 0.0   1   0.0 0.0 21.0, 21.0 -0.41
CC033/GeniUncJ m 30.0 0.0   1   0.0 0.0 30.0, 30.0 -0.62
CC035/UncJ f 21.5 3.5355   2   2.5 0.1644 19.0, 24.0 -0.41
CC035/UncJ m 87.0 76.37   2   54.0 0.8778 33.0, 141.0 0.04
CC036/UncJ f 188.3 71.0   3 40.989 0.377 113.0, 254.0 0.0
CC036/UncJ m 255.5 338.7   2   239.5 1.3257 16.0, 495.0 1.99
CC037/TauUncJ f 20.0 0.0   1   0.0 0.0 20.0, 20.0 -0.41
CC037/TauUncJ m 0.0 0.0   1   0.0 None -0.96
CC040/TauUncJ f 11.0 0.0   1   0.0 0.0 11.0, 11.0 -0.43
CC040/TauUncJ m 103.0 50.91   2   36.0 0.4943 67.0, 139.0 0.23
CC041/TauUncJ f 11.5 14.849   2   10.5 1.2912 1.0, 22.0 -0.43
CC041/TauUncJ m 4.5 9.6531   12 2.7866 2.1451 -0.91
CC043/GeniUncJ m 57.0 0.0   1   0.0 0.0 57.0, 57.0 -0.3
CC044/UncJ f 20.0 0.0   1   0.0 0.0 20.0, 20.0 -0.41
CC044/UncJ m 38.5 51.62   2   36.5 1.3407 2.0, 75.0 -0.52
CC051/TauUncJ f 74.5 44.548   2   31.5 0.598 43.0, 106.0 -0.28
CC051/TauUncJ m 48.0 31.512   3 18.193 0.6565 17.0, 80.0 -0.41
CC057/UncJ f 492.5 668.2   2   472.5 1.3568 20.0, 965.0 0.73
CC057/UncJ m 14.0 16.971   2   12.0 1.2122 2.0, 26.0 -0.8
CC059/TauUncJ f 1177.0 1626.0   3 938.7 1.3817 6.0, 3033.0 2.38
CC059/TauUncJ m 153.3 84.39   3 48.721 0.5504 86.0, 248.0 0.81
CC060/UncJ m 87.0 0.0   1   0.0 0.0 87.0, 87.0 0.04
CC061/GeniUncJ f 142.0 168.3   2   119.0 1.1852 23.0, 261.0 -0.12
CC061/GeniUncJ m 212.0 215.0   2   152.0 1.014 60.0, 364.0 1.49
CC068/TauUncJ f 0.0 0.0   2   0.0 None -0.46
CC068/TauUncJ m 0.0 0.0   2   0.0 None -0.96
CC074/UncJ f 6.0 0.0   1   0.0 0.0 6.0, 6.0 -0.44
CC074/UncJ m 58.0 0.0   1   0.0 0.0 58.0, 58.0 -0.29
CC075/UncJ f 11.0 0.0   1   0.0 0.0 11.0, 11.0 -0.43
CC078/TauUncJ f 296.5 85.56   2   60.5 0.2886 236.0, 357.0 0.26
CC078/TauUncJ m 287.7 179.3   3 103.5 0.6235 84.0, 422.0 2.36
CC079/TauUncJ f 108.0 67.88   2   48.0 0.6285 60.0, 156.0 -0.2
CC079/TauUncJ m 45.0 24.042   2   17.0 0.5343 28.0, 62.0 -0.44
CC080/TauUncJ f 4.0 5.6569   2   4.0 1.4142 -0.45
CC084/TauJ f 121.5 53.03   2   37.5 0.4365 84.0, 159.0 -0.16
CC084/TauJ m 76.0 0.0   1   0.0 0.0 76.0, 76.0 -0.08
NOD/ShiLtJ f 116.4 180.7   11 54.47 1.5526 3.0, 483.0 -0.18
NOD/ShiLtJ m 72.33 88.54   6 36.146 1.224 4.0, 193.0 -0.13
NZO/HlLtJ f 40.2 56.2   10 17.772 1.398 -0.36
NZO/HlLtJ m 37.7 41.82   10 13.225 1.1093 7.0, 143.0 -0.53
PWK/PhJ f 112.5 112.6   6 45.967 1.0009 29.0, 324.0 -0.19
PWK/PhJ m 80.43 51.38   7 19.42 0.6388 7.0, 138.0 -0.03
WSB/EiJ f 15.5 0.70711   2   0.5 0.0456 15.0, 16.0 -0.42
WSB/EiJ m 31.8 18.377   5 8.2183 0.5779 11.0, 54.0 -0.59


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 17.75 88.010137471 191.2008711145 -155.7008711145
A/J m 17.2857142857 94.0867945656 202.7124951851 -168.1410666137
C57BL/6J f 226.5454545455 75.0552974215 374.4648544419 78.626054649
C57BL/6J m 42.4615384615 69.0408320552 178.5275963788 -93.6045194557
CC001/UncJ f 55.0 143.7199526641 338.2440864478 -228.2440864478
CC001/UncJ m 414.0 124.4651300378 659.2965743355 168.7034256645
CC003/UncJ f 33.0 176.0202749421 379.9017422289 -313.9017422289
CC003/UncJ m 22.3333333333 143.7199526641 305.5774197811 -260.9107531145
CC004/TauUncJ f 199.3333333333 82.9767533586 362.8643828903 35.8022837763
CC004/TauUncJ m 291.2631578947 57.1085182979 403.812945129 178.7133706605
CC005/TauUncJ f 66.25 124.4651300378 311.5465743355 -179.0465743355
CC005/TauUncJ m 31.5 176.0202749421 378.4017422289 -315.4017422289
CC007/UncJ f 46.0 176.0202749421 392.9017422289 -300.9017422289
CC007/UncJ m 70.6666666667 143.7199526641 353.9107531145 -212.5774197811
CC008/GeniUncJ f 2.5 176.0202749421 349.4017422289 -344.4017422289
CC008/GeniUncJ m 103.0 176.0202749421 449.9017422289 -243.9017422289
CC009/UncJ f 63.3333333333 143.7199526641 346.5774197811 -219.9107531145
CC009/UncJ m 30.6666666667 143.7199526641 313.9107531145 -252.5774197811
CC011/UncJ f 202.6666666667 143.7199526641 485.9107531145 -80.5774197811
CC011/UncJ m 102.0 176.0202749421 448.9017422289 -244.9017422289
CC013/GeniUncJ f 155.6666666667 143.7199526641 438.9107531145 -127.5774197811
CC013/GeniUncJ m 92.0 143.7199526641 375.2440864478 -191.2440864478
CC016/GeniUncJ f 873.0 176.0202749421 1219.9017422289 526.0982577711
CC016/GeniUncJ m 25.0 176.0202749421 371.9017422289 -321.9017422289
CC017/UncJ f 9.0 143.7199526641 292.2440864478 -274.2440864478
CC017/UncJ m 6.25 124.4651300378 251.5465743355 -239.0465743355
CC018/UncJ f 211.0 143.7199526641 494.2440864478 -72.2440864478
CC018/UncJ m 187.6 111.3249966372 406.9999259448 -31.7999259448
CC019/TauUncJ f 187.8 111.3249966372 407.1999259448 -31.5999259448
CC019/TauUncJ m 44.0 176.0202749421 390.9017422289 -302.9017422289
CC023/GeniUncJ f 52.6666666667 143.7199526641 335.9107531145 -230.5774197811
CC023/GeniUncJ m 77.6666666667 143.7199526641 360.9107531145 -205.5774197811
CC026/GeniUncJ f 22.6 111.3249966372 241.9999259448 -196.7999259448
CC026/GeniUncJ m 26.3333333333 143.7199526641 309.5774197811 -256.9107531145
CC027/GeniUncJ f 590.6666666667 143.7199526641 873.9107531145 307.4225802189
CC027/GeniUncJ m 83.0 124.4651300378 328.2965743355 -162.2965743355
CC028/GeniUncJ f 109.25 124.4651300378 354.5465743355 -136.0465743355
CC028/GeniUncJ m 72.0 111.3249966372 291.3999259448 -147.3999259448
CC030/GeniUncJ f 245.0 176.0202749421 591.9017422289 -101.9017422289
CC030/GeniUncJ m 55.5 176.0202749421 402.4017422289 -291.4017422289
CC032/GeniUncJ f 63.6666666667 143.7199526641 346.9107531145 -219.5774197811
CC032/GeniUncJ m 183.75 124.4651300378 429.0465743355 -61.5465743355
CC035/UncJ f 21.5 176.0202749421 368.4017422289 -325.4017422289
CC035/UncJ m 87.0 176.0202749421 433.9017422289 -259.9017422289
CC036/UncJ f 188.3333333333 143.7199526641 471.5774197811 -94.9107531145
CC036/UncJ m 255.5 176.0202749421 602.4017422289 -91.4017422289
CC041/TauUncJ f 11.5 176.0202749421 358.4017422289 -335.4017422289
CC041/TauUncJ m 4.5 71.8599763321 146.1220432239 -137.1220432239
CC051/TauUncJ f 74.5 176.0202749421 421.4017422289 -272.4017422289
CC051/TauUncJ m 48.0 143.7199526641 331.2440864478 -235.2440864478
CC057/UncJ f 492.5 176.0202749421 839.4017422289 145.5982577711
CC057/UncJ m 14.0 176.0202749421 360.9017422289 -332.9017422289
CC059/TauUncJ f 1176.6666666667 143.7199526641 1459.9107531145 893.4225802189
CC059/TauUncJ m 153.3333333333 143.7199526641 436.5774197811 -129.9107531145
CC061/GeniUncJ f 142.0 176.0202749421 488.9017422289 -204.9017422289
CC061/GeniUncJ m 212.0 176.0202749421 558.9017422289 -134.9017422289
CC068/TauUncJ f 0.0 176.0202749421 346.9017422289 -346.9017422289
CC068/TauUncJ m 0.0 176.0202749421 346.9017422289 -346.9017422289
CC078/TauUncJ f 296.5 176.0202749421 643.4017422289 -50.4017422289
CC078/TauUncJ m 287.6666666667 143.7199526641 570.9107531145 4.4225802189
CC079/TauUncJ f 108.0 176.0202749421 454.9017422289 -238.9017422289
CC079/TauUncJ m 45.0 176.0202749421 391.9017422289 -301.9017422289
NOD/ShiLtJ f 116.3636363636 75.0552974215 264.2830362601 -31.5557635328
NOD/ShiLtJ m 72.3333333333 101.6253531206 272.6171475916 -127.9504809249
NZO/HlLtJ f 40.2 78.7186600377 195.3391754274 -114.9391754274
NZO/HlLtJ m 37.7 78.7186600377 192.8391754274 -117.4391754274
PWK/PhJ f 112.5 101.6253531206 312.7838142582 -87.7838142582
PWK/PhJ m 80.4285714286 94.0867945656 265.8553523279 -104.9982094708
WSB/EiJ f 15.5 176.0202749421 362.4017422289 -331.4017422289
WSB/EiJ m 31.8 111.3249966372 251.1999259448 -187.5999259448


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 17.5178571429 64.4168246836 144.4708954731 -109.4351811873
C57BL/6J both 134.5034965035 50.9900337368 234.9949401478 34.0120528592
CC001/UncJ both 234.5 95.0618132968 421.8483532676 47.1516467324
CC003/UncJ both 27.6666666667 113.6205989076 251.5907784038 -196.2574450705
CC004/TauUncJ both 245.298245614 50.3649790532 344.5578279924 146.0386632357
CC005/TauUncJ both 48.875 107.7899644981 261.3080648358 -163.5580648358
CC007/UncJ both 58.3333333333 113.6205989076 282.2574450705 -165.5907784038
CC008/GeniUncJ both 52.75 124.4651300378 298.0465743355 -192.5465743355
CC009/UncJ both 47.0 101.6253531206 247.2838142582 -153.2838142582
CC011/UncJ both 152.3333333333 113.6205989076 376.2574450705 -71.5907784038
CC013/GeniUncJ both 123.8333333333 101.6253531206 324.1171475916 -76.4504809249
CC016/GeniUncJ both 449.0 124.4651300378 694.2965743355 203.7034256645
CC017/UncJ both 7.625 95.0618132968 194.9733532676 -179.7233532676
CC018/UncJ both 199.3 90.8964791261 378.4392893897 20.1607106103
CC019/TauUncJ both 115.9 104.134999 321.1298383923 -89.3298383923
CC023/GeniUncJ both 65.1666666667 101.6253531206 265.4504809249 -135.1171475916
CC026/GeniUncJ both 24.4666666667 90.8964791261 203.6059560564 -154.6726227231
CC027/GeniUncJ both 336.8333333333 95.0618132968 524.181686601 149.4849800657
CC028/GeniUncJ both 90.625 83.4937474779 255.1749444586 -73.9249444586
CC030/GeniUncJ both 150.25 124.4651300378 395.5465743355 -95.0465743355
CC032/GeniUncJ both 123.7083333333 95.0618132968 311.056686601 -63.6400199343
CC035/UncJ both 54.25 124.4651300378 299.5465743355 -191.0465743355
CC036/UncJ both 221.9166666667 113.6205989076 445.8407784038 -2.0074450705
CC041/TauUncJ both 8.0 95.0618132968 195.3483532676 -179.3483532676
CC051/TauUncJ both 61.25 113.6205989076 285.1741117372 -162.6741117372
CC057/UncJ both 253.25 124.4651300378 498.5465743355 7.9534256645
CC059/TauUncJ both 665.0 101.6253531206 865.2838142582 464.7161857418
CC061/GeniUncJ both 177.0 124.4651300378 422.2965743355 -68.2965743355
CC068/TauUncJ both 0.0 124.4651300378 245.2965743355 -245.2965743355
CC078/TauUncJ both 292.0833333333 113.6205989076 516.0074450705 68.1592215962
CC079/TauUncJ both 76.5 124.4651300378 321.7965743355 -168.7965743355
NOD/ShiLtJ both 94.3484848485 63.1684455799 218.8412106596 -30.1442409626
NZO/HlLtJ both 38.95 55.6624983186 148.6499629724 -70.7499629724
PWK/PhJ both 96.4642857143 69.2460058569 232.9347013073 -40.0061298787
WSB/EiJ both 23.65 104.134999 228.8798383923 -181.5798383923




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA