Project measure / variable:   CSNA03   infusions_cc_0p18

ID, description, units MPD:110396   infusions_cc_0p18   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC   [n]  0.18 mg/kg  
cocaine study
Data set, strains CSNA03   CC w/par   10 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC 0.18 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means75.17   n 81.39   n
Median of the strain means81.5   n 75.98   n
SD of the strain means± 40.086 ± 31.989
Coefficient of variation (CV)0.5333 0.393
Min–max range of strain means4.1667   –   125.4   n 42.333   –   141.4   n
Mean sample size per strain7.6   mice 7.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 82.7934 82.7934 0.0343 0.8534
strain 7 93962.6896 13423.2414 5.5627 < 0.0001
sex:strain 7 7302.4126 1043.2018 0.4323 0.8803
Residuals 119 287157.8824 2413.0914


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 75.17 79.96   9 26.654 1.0638 0.0
A/J m 76.47 64.29   7 24.299 0.8407 17.5, 187.5 -0.15
C57BL/6J f 107.8 37.833   11 11.407 0.3509 58.0, 186.5 0.81
C57BL/6J m 84.0 22.835   11 6.8851 0.2718 37.5, 113.0 0.08
CAST/EiJ f 96.47 56.43   4 28.217 0.585 36.0, 171.0 0.53
CAST/EiJ m 75.5 43.373   3 25.042 0.5745 28.0, 113.0 -0.18
CC004/TauUncJ f 125.4 67.07   9 22.356 0.5349 43.5, 238.0 1.25
CC004/TauUncJ m 133.1 42.838   9 14.279 0.3218 60.0, 200.5 1.62
CC026/GeniUncJ f 38.7 34.045   5 15.225 0.8797 10.5, 80.0 -0.91
CC026/GeniUncJ m 42.333 34.757   3 20.067 0.821 12.5, 80.5 -1.22
CC041/TauUncJ f 4.1667 6.3705   3 3.678 1.5289 -1.77
CC041/TauUncJ m 58.0 0.0   1   0.0 0.0 58.0, 58.0 -0.73
NOD/ShiLtJ f 68.18 42.507   12 12.271 0.6234 11.4, 166.5 -0.17
NOD/ShiLtJ m 65.99 47.926   9 15.975 0.7263 9.8, 152.5 -0.48
NZO/HlLtJ f 87.83 50.29   12 14.516 0.5725 14.0, 213.5 0.32
NZO/HlLtJ m 79.32 35.056   11 10.57 0.442 3.5, 121.5 -0.06
PWK/PhJ f 117.8 50.67   10 16.024 0.4303 58.5, 196.0 1.06
PWK/PhJ m 141.4 46.161   10 14.597 0.3263 63.5, 216.0 1.88
WSB/EiJ f 30.2 0.0   1   0.0 0.0 30.2, 30.2 -1.12
WSB/EiJ m 57.83 42.473   6 17.34 0.7344 30.5, 141.5 -0.74


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 75.1666666667 16.3744090614 107.5896320262 42.7437013071
A/J m 76.4714285714 18.5668346752 113.235615618 39.7072415249
C57BL/6J f 107.8181818182 14.8112102783 137.1458574604 78.4905061759
C57BL/6J m 84.0 14.8112102783 113.3276756422 54.6723243578
CAST/EiJ f 96.475 24.5616135921 145.1094480393 47.8405519607
CAST/EiJ m 75.5 28.3613084383 131.6582233347 19.3417766653
CC004/TauUncJ f 125.3888888889 16.3744090614 157.8118542484 92.9659235294
CC004/TauUncJ m 133.1111111111 16.3744090614 165.5340764706 100.6881457516
CC026/GeniUncJ f 38.7 21.9685750516 82.1999727456 -4.7999727456
CC026/GeniUncJ m 42.3333333333 28.3613084383 98.4915566681 -13.8248900014
NOD/ShiLtJ f 68.1833333333 14.1806542191 96.2624450007 40.104221666
NOD/ShiLtJ m 65.9888888889 16.3744090614 98.4118542484 33.5659235294
NZO/HlLtJ f 87.8333333333 14.1806542191 115.9124450007 59.754221666
NZO/HlLtJ m 79.3181818182 14.8112102783 108.6458574604 49.9905061759
PWK/PhJ f 117.775 15.534128392 148.5341257098 87.0158742902
PWK/PhJ m 141.45 15.534128392 172.2091257098 110.6908742902


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 75.819047619 12.3778897835 100.3285056501 51.309589588
C57BL/6J both 95.9090909091 10.4731072254 116.6468892322 75.171292586
CAST/EiJ both 85.9875 18.759242246 123.1326732537 48.8423267463
CC004/TauUncJ both 129.25 11.5784556852 152.1764986719 106.3235013281
CC026/GeniUncJ both 40.5166666667 17.9372664175 76.0342456839 4.9990876494
NOD/ShiLtJ both 67.0861111111 10.8306535605 88.5318868882 45.640335334
NZO/HlLtJ both 83.5757575758 10.2525960614 103.8769217702 63.2745933813
PWK/PhJ both 129.6125 10.9842875258 151.3624863728 107.8625136272




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA