Project measure / variable:   CSNA03   infusions_cc_1p8

ID, description, units MPD:110392   infusions_cc_1p8   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC   [n]  1.8 mg/kg  
cocaine study
Data set, strains CSNA03   CC w/par   10 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, CC 1.8 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means27.868   n 26.186   n
Median of the strain means26.866   n 24.187   n
SD of the strain means± 18.691 ± 13.674
Coefficient of variation (CV)0.6707 0.5222
Min–max range of strain means7.0   –   69.34   n 11.3   –   60.44   n
Mean sample size per strain6.6   mice 6.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 972.271 972.271 1.2333 0.2694
strain 6 20922.2286 3487.0381 4.4231 0.0005
sex:strain 6 7073.3174 1178.8862 1.4953 0.1873
Residuals 101 79625.8922 788.3752


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 26.286 14.637   7 5.5322 0.5568 16.5, 58.0 -0.08
A/J m 30.929 24.308   7 9.1875 0.7859 10.0, 82.0 0.35
C57BL/6J f 34.955 24.378   11 7.3502 0.6974 18.0, 85.5 0.38
C57BL/6J m 24.273 6.2023   11 1.8701 0.2555 16.0, 37.5 -0.14
CAST/EiJ f 30.0 0.0   1   0.0 0.0 30.0, 30.0 0.11
CAST/EiJ m 17.75 1.0607   2   0.75 0.0598 17.0, 18.5 -0.62
CC004/TauUncJ f 42.312 33.361   8 11.795 0.7884 12.0, 110.0 0.77
CC004/TauUncJ m 60.44 68.24   8 24.127 1.1291 15.5, 175.0 2.5
CC026/GeniUncJ f 11.3 2.2804   5 1.0198 0.2018 8.0, 13.5 -0.89
CC026/GeniUncJ m 11.3 0.81854   3 0.47258 0.0724 10.4, 12.0 -1.09
CC041/TauUncJ f 7.3333 12.702   3 7.3333 1.7321 -1.1
CC041/TauUncJ m 25.0 0.0   1   0.0 0.0 25.0, 25.0 -0.09
NOD/ShiLtJ f 22.71 7.5282   10 2.3806 0.3315 7.4, 37.5 -0.28
NOD/ShiLtJ m 19.171 9.7931   7 3.7015 0.5108 3.2, 34.5 -0.51
NZO/HlLtJ f 27.445 16.819   11 5.0712 0.6128 15.0, 69.5 -0.02
NZO/HlLtJ m 16.4 4.1015   10 1.297 0.2501 11.5, 24.5 -0.72
PWK/PhJ f 69.34 53.35   9 17.784 0.7694 25.5, 185.0 2.22
PWK/PhJ m 32.5 13.194   8 4.6646 0.406 18.5, 58.5 0.46
WSB/EiJ f 7.0 0.0   1   0.0 0.0 7.0, 7.0 -1.12
WSB/EiJ m 24.1 18.49   6 7.5485 0.7672 11.5, 58.0 -0.15


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 26.2857142857 10.6124937865 47.3380472287 5.2333813427
A/J m 30.9285714286 10.6124937865 51.9809043715 9.8762384856
C57BL/6J f 34.9545454545 8.4658413671 51.7484974406 18.1605934685
C57BL/6J m 24.2727272727 8.4658413671 41.0666792587 7.4787752867
CC004/TauUncJ f 42.3125 9.9270789421 62.0051542662 22.6198457338
CC004/TauUncJ m 60.4375 9.9270789421 80.1301542662 40.7448457338
CC026/GeniUncJ f 11.3 12.5568719877 36.2094562622 -13.6094562622
CC026/GeniUncJ m 11.3 16.2108520296 43.4579697555 -20.8579697555
NOD/ShiLtJ f 22.71 8.879049333 40.3236454387 5.0963545613
NOD/ShiLtJ m 19.1714285714 10.6124937865 40.2237615144 -1.8809043715
NZO/HlLtJ f 27.4454545455 8.4658413671 44.2394065315 10.6515025594
NZO/HlLtJ m 16.4 8.879049333 34.0136454387 -1.2136454387
PWK/PhJ f 69.3444444444 9.3593397831 87.9108569394 50.7780319495
PWK/PhJ m 32.5 9.9270789421 52.1926542662 12.8073457338


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 28.6071428571 7.5041663217 43.4933902409 13.7208954734
C57BL/6J both 29.6136363636 5.9862538391 41.4887536959 17.7385190314
CC004/TauUncJ both 51.375 7.0195048373 65.2998093712 37.4501906288
CC026/GeniUncJ both 11.3 10.2526430451 31.6384858709 -9.0384858709
NOD/ShiLtJ both 20.9407142857 6.9184995018 34.6651562414 7.21627233
NZO/HlLtJ both 21.9227272727 6.1340848362 34.0911015371 9.7543530084
PWK/PhJ both 50.9222222222 6.8217325054 64.454704487 37.3897399575




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA