Project measure / variable:   CSNA03   extinction_active_in_s7

ID, description, units MPD:110204   extinction_active_in_s7   extinction, active lever presses (intravenous self administration), founders   [n]  session 7  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
Ontology mappings

  STRAIN COMPARISON PLOT
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CSNA03 - extinction, active lever presses (intravenous self administration), founders session 7



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means64.94   n 39.209   n
Median of the strain means55.0   n 33.909   n
SD of the strain means± 38.538 ± 20.248
Coefficient of variation (CV)0.5934 0.5164
Min–max range of strain means25.0   –   139.3   n 17.857   –   77.83   n
Mean sample size per strain6.7   mice 6.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 22198.6634 22198.6634 4.4325 0.0384
strain 5 62308.7091 12461.7418 2.4883 0.0381
sex:strain 5 40309.2458 8061.8492 1.6097 0.1671
Residuals 79 395644.4147 5008.1571


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 25.0 27.092   7 10.24 1.0837 -1.04
A/J m 17.857 17.563   7 6.6384 0.9836 -1.05
C57BL/6J f 139.3 174.9   11 52.75 1.2561 16.0, 530.0 1.93
C57BL/6J m 33.909 27.197   11 8.2003 0.8021 6.0, 95.0 -0.26
CAST/EiJ f 78.0 0.0   1   0.0 0.0 78.0, 78.0 0.34
CAST/EiJ m 42.0 7.0711   2   5.0 0.1684 37.0, 47.0 0.14
NOD/ShiLtJ f 54.0 64.23   9 21.409 1.1894 -0.28
NOD/ShiLtJ m 31.167 19.753   6 8.064 0.6338 5.0, 53.0 -0.4
NZO/HlLtJ f 28.8 29.813   10 9.4279 1.0352 -0.94
NZO/HlLtJ m 21.9 10.115   10 3.1988 0.4619 7.0, 36.0 -0.85
PWK/PhJ f 74.5 39.889   6 16.284 0.5354 31.0, 131.0 0.25
PWK/PhJ m 77.83 55.46   6 22.643 0.7126 28.0, 172.0 1.91
WSB/EiJ f 55.0 55.97   3 32.316 1.0177 6.0, 116.0 -0.26
WSB/EiJ m 49.8 24.773   5 11.079 0.4974 22.0, 77.0 0.52


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 25.0 26.7479162028 78.240395429 -28.240395429
A/J m 17.8571428571 26.7479162028 71.0975382862 -35.3832525719
C57BL/6J f 139.2727272727 21.3374556469 181.743870351 96.8015841945
C57BL/6J m 33.9090909091 21.3374556469 76.3802339873 -8.5620521691
NOD/ShiLtJ f 54.0 23.5894447873 100.953615336 7.046384664
NOD/ShiLtJ m 31.1666666667 28.8910515222 88.6728662427 -26.3395329094
NZO/HlLtJ f 28.8 22.3789122799 73.3441106523 -15.7441106523
NZO/HlLtJ m 21.9 22.3789122799 66.4441106523 -22.6441106523
PWK/PhJ f 74.5 28.8910515222 132.0061995761 16.9938004239
PWK/PhJ m 77.8333333333 28.8910515222 135.3395329094 20.3271337573
WSB/EiJ f 55.0 40.8581168939 136.326047361 -26.326047361
WSB/EiJ m 49.8 31.6485612575 112.7948854084 -13.1948854084


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 21.4285714286 18.9136329296 59.0752160695 -16.2180732124
C57BL/6J both 86.5909090909 15.0878595812 116.6225423663 56.5592758155
NOD/ShiLtJ both 42.5833333333 18.6490935666 79.7034255436 5.463241123
NZO/HlLtJ both 25.35 15.8242806287 56.8474427042 -6.1474427042
PWK/PhJ both 76.1666666667 20.4290584469 116.8296903472 35.5036429862
WSB/EiJ both 52.4 25.840942058 103.8351085519 0.9648914481




  GWAS USING LINEAR MIXED MODELS