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Project measure / variable:   CSNA03   infusions_in_0p18

ID, description, units MPD:110194   infusions_in_0p18   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  0.18 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 0.18 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means83.35   n 82.93   n
Median of the strain means87.83   n 76.47   n
SD of the strain means± 29.151 ± 27.224
Coefficient of variation (CV)0.3497 0.3283
Min–max range of strain means30.2   –   117.8   n 57.83   –   141.4   n
Mean sample size per strain8.4   mice 8.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 88.6822 88.6822 0.0375 0.8469
strain 5 47501.6275 9500.3255 4.0165 0.0024
sex:strain 5 6727.492 1345.4984 0.5688 0.7237
Residuals 97 229439.138 2365.3519


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 75.17 79.96   9 26.654 1.0638 -0.28
A/J m 76.47 64.29   7 24.299 0.8407 17.5, 187.5 -0.24
C57BL/6J f 107.8 37.833   11 11.407 0.3509 58.0, 186.5 0.84
C57BL/6J m 84.0 22.835   11 6.8851 0.2718 37.5, 113.0 0.04
CAST/EiJ f 96.47 56.43   4 28.217 0.585 36.0, 171.0 0.45
CAST/EiJ m 75.5 43.373   3 25.042 0.5745 28.0, 113.0 -0.27
NOD/ShiLtJ f 68.18 42.507   12 12.271 0.6234 11.4, 166.5 -0.52
NOD/ShiLtJ m 65.99 47.926   9 15.975 0.7263 9.8, 152.5 -0.62
NZO/HlLtJ f 87.83 50.29   12 14.516 0.5725 14.0, 213.5 0.15
NZO/HlLtJ m 79.32 35.056   11 10.57 0.442 3.5, 121.5 -0.13
PWK/PhJ f 117.8 50.67   10 16.024 0.4303 58.5, 196.0 1.18
PWK/PhJ m 141.4 46.161   10 14.597 0.3263 63.5, 216.0 2.15
WSB/EiJ f 30.2 0.0   1   0.0 0.0 30.2, 30.2 -1.82
WSB/EiJ m 57.83 42.473   6 17.34 0.7344 30.5, 141.5 -0.92


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 75.1666666667 16.2116279873 107.3422606161 42.9910727172
A/J m 76.4714285714 18.3822582865 112.955122804 39.9877343388
C57BL/6J f 107.8181818182 14.6639692567 136.922101601 78.7142620353
C57BL/6J m 84.0 14.6639692567 113.1039197829 54.8960802171
CAST/EiJ f 96.475 24.317441981 144.7383909242 48.2116090758
CAST/EiJ m 75.5 28.0793633474 131.2297634842 19.7702365158
NOD/ShiLtJ f 68.1833333333 14.0396816737 96.0482150754 40.3184515913
NOD/ShiLtJ m 65.9888888889 16.2116279873 98.1644828383 33.8132949394
NZO/HlLtJ f 87.8333333333 14.0396816737 115.6982150754 59.9684515913
NZO/HlLtJ m 79.3181818182 14.6639692567 108.422101601 50.2142620353
PWK/PhJ f 117.775 15.3797007058 148.2994485847 87.2505514153
PWK/PhJ m 141.45 15.3797007058 171.9744485847 110.9255514153


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 75.819047619 12.2548388577 100.1415104408 51.4965847973
C57BL/6J both 95.9090909091 10.3689921006 116.4886699467 75.3295118715
CAST/EiJ both 85.9875 18.5727530976 122.8492737009 49.1257262991
NOD/ShiLtJ both 67.0861111111 10.7229840005 88.3682660801 45.8039561421
NZO/HlLtJ both 83.5757575758 10.1506730794 103.7220337902 63.4294813614
PWK/PhJ both 129.6125 10.8750906617 151.1965445862 108.0284554138




  GWAS USING LINEAR MIXED MODELS