Project measure / variable:   CSNA03   infusions_in_0p32

ID, description, units MPD:110192   infusions_in_0p32   dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders   [n]  0.32 mg/kg  
cocaine study
Data set, strains CSNA03   inbred w/CC8   7 strains     sex: both     age:
Procedure operant conditioning chamber
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  STRAIN COMPARISON PLOT
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CSNA03 - dose response, mean number of infusions (intravenous self administration) on last two stabilized sessions, founders 0.32 mg/kg



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means73.17   n 72.93   n
Median of the strain means79.04   n 66.23   n
SD of the strain means± 28.151 ± 30.393
Coefficient of variation (CV)0.3848 0.4167
Min–max range of strain means19.0   –   105.9   n 36.186   –   124.0   n
Mean sample size per strain9.9   mice 8.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 311.5837 311.5837 0.2037 0.6526
strain 6 64312.7754 10718.7959 7.0064 < 0.0001
sex:strain 6 9057.6838 1509.614 0.9868 0.4375
Residuals 117 178993.5819 1529.8597


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 85.9 59.69   11 17.998 0.6949 10.4, 195.5 0.45
A/J m 101.3 59.63   8 21.084 0.5884 22.667, 214.5 0.93
C57BL/6J f 90.35 26.096   13 7.2378 0.2888 47.0, 132.5 0.61
C57BL/6J m 66.23 22.212   13 6.1604 0.3354 39.5, 117.0 -0.22
CAST/EiJ f 79.04 47.101   5 21.064 0.5959 15.5, 138.0 0.21
CAST/EiJ m 50.2 34.97   4 17.485 0.6966 21.5, 95.5 -0.75
NOD/ShiLtJ f 57.2 25.473   13 7.0651 0.4453 13.8, 116.0 -0.57
NOD/ShiLtJ m 58.24 39.001   9 13.0 0.6696 -0.48
NZO/HlLtJ f 74.77 39.943   13 11.078 0.5342 22.5, 162.5 0.06
NZO/HlLtJ m 74.36 25.377   11 7.6515 0.3413 35.0, 113.5 0.05
PWK/PhJ f 105.9 42.025   11 12.671 0.3968 55.5, 181.5 1.16
PWK/PhJ m 124.0 53.64   10 16.961 0.4327 75.0, 256.0 1.68
WSB/EiJ f 19.0 8.3516   3 4.8218 0.4396 10.0, 26.5 -1.92
WSB/EiJ m 36.186 20.824   7 7.8706 0.5755 19.0, 80.5 -1.21


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 85.9 11.7931400484 109.2556958899 62.5443041101
A/J m 101.345875 13.8286824853 128.7328560209 73.9588939791
C57BL/6J f 90.3461538462 10.8481110522 111.8302693298 68.8620383625
C57BL/6J m 66.2307692308 10.8481110522 87.7148847144 44.7466537471
CAST/EiJ f 79.04 17.4920534771 113.6820953047 44.3979046953
CAST/EiJ m 50.2 19.5567103204 88.9310399922 11.4689600078
NOD/ShiLtJ f 57.2 10.8481110522 78.6841154837 35.7158845163
NOD/ShiLtJ m 58.2444444444 13.0378068803 84.0651377726 32.4237511163
NZO/HlLtJ f 74.7692307692 10.8481110522 96.2533462529 53.2851152856
NZO/HlLtJ m 74.3636363636 11.7931400484 97.7193322535 51.0079404738
PWK/PhJ f 105.9090909091 11.7931400484 129.264786799 82.5533950192
PWK/PhJ m 123.95 12.3687496305 148.4456605045 99.4543394955
WSB/EiJ f 19.0 22.5821439359 63.722752731 -25.722752731
WSB/EiJ m 36.1857142857 14.7834834201 65.4636285252 6.9078000462


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 93.6229375 9.0872247067 111.6197098491 75.6261651509
C57BL/6J both 78.2884615385 7.6707728881 93.4800252848 63.0968977922
CAST/EiJ both 64.62 13.1190401078 90.6015714785 38.6384285215
NOD/ShiLtJ both 57.7222222222 8.4803585073 74.517127864 40.9273165805
NZO/HlLtJ both 74.5664335664 8.0118609824 90.43350441 58.6993627229
PWK/PhJ both 114.9295454545 8.5449417731 131.85235487 98.0067360391
WSB/EiJ both 27.5928571429 13.4954122461 54.319813919 0.8659003667




  GWAS USING LINEAR MIXED MODELS