MPD: JaxKOMP-EAP genotype: Gbp7<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Gbp7^em1(IMPC)J/Mmjax -/- Gene Gbp7

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.0417	2.0634	0.037464	0.886	0.625
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.83333	3.1583	-0.17446	0.947	0.797
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-2.0626	2.6707	-0.63620	0.775	0.460
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-4.3686	3.2260	-0.80255	0.604	0.209
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	2.2917	6.0063	0.32824	0.887	0.711
body composition	body length	-0.13207	0.070113	-1.1723	0.282	0.0718
body composition	body weight (at time of DXA)	1.0346	0.81339	0.94408	0.430	0.215
body composition	bone area, whole body scan, head excluded	-0.26546	0.14236	-0.86163	0.276	0.0745
body composition	bone mineral content of whole body scan, head excluded	-0.0028092	0.012452	-0.020480	0.926	0.823
body composition	bone mineral content to body weight ratio	0.000062868	0.00044670	0.23843	0.956	0.889
body composition	bone mineral density of whole body scan, head excluded	0.00073446	0.00074408	0.84748	0.633	0.333
body composition	fat tissue mass of whole body scan, head excluded	0.11009	0.38479	0.19093	0.889	0.777
body composition	fat tissue mass to body weight ratio	0.0065356	0.011672	0.36569	0.771	0.581
body composition	lean tissue mass of whole body scan, head excluded	-0.58618	0.33937	-1.2529	0.357	0.0970
body composition	lean tissue mass to body weight ratio	-0.0037136	0.010167	-0.26323	0.862	0.718
body composition	percent fat, whole body scan, head excluded	0.57269	1.1096	0.33809	0.795	0.610
body composition	ratio of soft-tissue attenuation coefficients	-0.00067120	0.0012348	-0.35484	0.781	0.592
body composition	tissue area	-0.56170	0.23460	-1.5150	0.163	0.0248
body composition	total tissue mass, whole body scan, head excluded	-0.59613	0.29361	-1.6653	0.201	0.0535
clinical blood chemistry	alanine transaminase (plasma ALT)	-3.8086	5.3718	-0.36275	0.794	0.484
clinical blood chemistry	albumin (plasma Alb)	0.21240	0.58928	0.35068	0.897	0.721
clinical blood chemistry	alkaline phosphatase (plasma ALP)	12.539	4.2826	1.4109	0.0521	0.00658
clinical blood chemistry	aspartate transaminase (plasma AST)	4.7061	7.4129	0.23028	0.801	0.531
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.40455	0.20689	1.1279	0.397	0.0602
clinical blood chemistry	blood urea nitrogen (BUN)	-1.6796	1.4747	-0.72251	0.530	0.264
clinical blood chemistry	calcium (plasma Ca)	0.00039510	0.075541	0.35646	0.997	0.996
clinical blood chemistry	creatinine (plasma)	-0.0062691	0.020121	-0.021452	0.867	0.758
clinical blood chemistry	glucose (plasma GLU, no fast)	-0.58333	9.7272	0.27702	0.973	0.953
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.61715	2.8919	-0.17878	0.942	0.833
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.031043	0.0094693	1.4769	0.0610	0.00271
clinical blood chemistry	phosphorus (plasma phosphate)	-0.015878	0.37007	-0.069169	0.989	0.966
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.022030	0.0059090	-1.4373	0.0272	0.000832
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.3472	3.8167	-0.63355	0.806	0.543
clinical blood chemistry	total protein (plasma TP)	0.83333	0.69465	0.56882	0.518	0.240
clinical blood chemistry	triglyceride (plasma TG, no fast)	-18.810	10.117	-0.79837	0.283	0.0732
ERG v2.0	left eye a-wave amplitude (Photopic)	0.060913	1.5625	0.077034	0.983	0.969
ERG v2.0	left eye a-wave amplitude (Scotopic)	-5.8657	16.172	-0.33389	0.900	0.723
ERG v2.0	left eye a-wave implicit timing (Photopic)	-0.31586	1.4664	0.0027545	0.965	0.833
ERG v2.0	left eye a-wave implicit timing (Scotopic)	-1.8123	0.84675	-1.5079	0.403	0.0519
ERG v2.0	left eye b-wave amplitude (Photopic)	-12.340	7.8229	-1.2402	0.533	0.137
ERG v2.0	left eye b-wave amplitude (Scotopic)	18.488	32.346	0.38087	0.852	0.577
ERG v2.0	left eye b-wave implicit timing (Photopic)	3.4819	2.8688	0.77457	0.605	0.246
ERG v2.0	left eye b-wave implicit timing (Scotopic)	-15.666	8.4981	-1.4415	0.497	0.0865
ERG v2.0	left eye c-wave amplitude (Scotopic)	18.192	30.571	0.56135	0.821	0.562
ERG v2.0	left eye c-wave implicit timing (Scotopic)	26.490	42.788	0.19360	0.870	0.546
ERG v2.0	left eye FO-like wave amplitude (Scotopic)	1.8481	43.688	-0.26699	0.981	0.967
ERG v2.0	left eye FO-like wave implicit timing (Scotopic)	-183.90	202.87	-0.55949	0.839	0.380
ERG v2.0	right eye a-wave amplitude (Photopic)	0.10565	2.4751	0.14897	0.996	0.967
ERG v2.0	right eye a-wave amplitude (Scotopic)	49.644	22.753	1.4745	0.413	0.0481
ERG v2.0	right eye a-wave implicit timing (Photopic)	0.30836	2.0899	0.12427	0.970	0.885
ERG v2.0	right eye a-wave implicit timing (Scotopic)	-0.32828	1.1043	-0.26820	0.929	0.771
ERG v2.0	right eye b-wave amplitude (Photopic)	0.23423	7.3481	-0.20481	0.987	0.975
ERG v2.0	right eye b-wave amplitude (Scotopic)	-37.735	49.110	-0.44282	0.910	0.456
ERG v2.0	right eye b-wave implicit timing (Photopic)	4.6934	4.6550	1.2891	0.686	0.332
ERG v2.0	right eye b-wave implicit timing (Scotopic)	-3.9013	8.1905	-0.28985	0.899	0.641
ERG v2.0	right eye c-wave amplitude (Scotopic)	-91.141	40.690	-1.6199	0.388	0.0432
ERG v2.0	right eye c-wave implicit timing (Scotopic)	-163.19	74.960	-1.5420	0.438	0.0471
ERG v2.0	right eye FO-like wave amplitude (Scotopic)	60.624	51.264	0.72362	0.653	0.257
ERG v2.0	right eye FO-like wave implicit timing (Scotopic)	-153.98	175.93	-0.36527	0.826	0.397
glucose tolerance test	amount glucose injected	-4.2599	1.9494	-0.84476	0.284	0.0368
glucose tolerance test	plasma glucose, 0min	-8.9567	5.8013	-1.0199	0.311	0.133
glucose tolerance test	plasma glucose, 15min	61.626	26.012	1.6681	0.189	0.0245
glucose tolerance test	plasma glucose, 30min	60.322	23.368	1.7638	0.139	0.0150
glucose tolerance test	plasma glucose, 60min	6.5308	17.223	0.40178	0.895	0.707
glucose tolerance test	plasma glucose, 120min	-1.5422	9.1426	-0.23270	0.948	0.867
grip strength	body weight (at time of grip strength test)	1.2172	0.74407	1.2711	0.261	0.112
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-6.4691	5.6645	-0.23151	0.471	0.262
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.43447	0.26123	-0.44886	0.270	0.107
grip strength	forelimb and hindlimb grip strength by trial, trial1	-15.502	7.8473	-0.77360	0.245	0.0572
grip strength	forelimb and hindlimb grip strength by trial, trial2	-2.0664	6.9273	0.11352	0.890	0.767
grip strength	forelimb and hindlimb grip strength by trial, trial3	0.83883	7.4698	0.25995	0.962	0.911
grip strength	forelimb grip strength (mean of trials), average	-4.6127	4.6504	-0.32208	0.592	0.329
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.33738	0.19437	-0.61811	0.298	0.0929
grip strength	forelimb grip strength by trial, trial1	-1.6403	6.6799	0.091621	0.926	0.808
grip strength	forelimb grip strength by trial, trial2	-6.8000	5.4046	-0.52074	0.543	0.218
grip strength	forelimb grip strength by trial, trial3	0.21690	5.5883	0.27500	0.985	0.969
heart weight	heart weight, normalized to body weight	0.26825	0.13450	0.48070	0.185	0.0547
heart weight	heart weight, weight	7.3420	3.9103	0.57071	0.223	0.0696
hematology	basophil differential (percent of total WBC)	-0.012312	0.026947	-0.17523	0.892	0.651
hematology	calculated hemoglobin (cHGB)	-0.25566	0.19493	-1.0022	0.476	0.200
hematology	eosinophil differential (percent of total WBC)	-0.23750	0.14731	-0.58323	0.501	0.117
hematology	hematocrit (HCT)	-0.73333	0.55598	-1.0250	0.486	0.197
hematology	hemoglobin concentration distribution width (HDW)	-0.034424	0.028056	-0.94908	0.541	0.230
hematology	large unstained cells (percent of total WBC)	-0.27224	0.11538	-1.5820	0.227	0.0252
hematology	lymphocyte differential (percent of total WBC)	-3.4839	2.0786	-1.3895	0.330	0.104
hematology	mean corpuscular hemoglobin (CHr)	0.046361	0.063395	0.39958	0.701	0.470
hematology	mean platelet volume (MPV)	0.48355	0.10543	1.6909	0.00135	0.0000747
hematology	mean RBC corpuscular hemoglobin (MCH)	0.17500	0.20958	0.65440	0.750	0.410
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.062414	0.53635	-0.14432	0.962	0.908
hematology	mean RBC corpuscular volume (MCV)	0.10850	0.19952	0.23870	0.777	0.591
hematology	measured hemoglobin (mHGB)	-0.18767	0.17642	-0.68526	0.601	0.296
hematology	monocyte differential (percent of total WBC)	0.63224	0.20148	1.7993	0.107	0.00389
hematology	neutrophil differential (percent of total WBC)	3.3707	1.9774	1.5022	0.304	0.0986
hematology	platelet count (PLT; units per volume x 10³)	-72.470	35.484	-0.88083	0.329	0.0503
hematology	RBC corpuscular distribution width (RDW)	0.17576	0.19327	0.60923	0.621	0.370
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.013113	0.15855	-0.050502	0.972	0.935
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.33215	0.16946	-1.5102	0.262	0.0597
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-27.434	14.901	-1.0693	0.412	0.0755
hematology	reticulocyte differential (percent of total RBC)	-0.20743	0.16022	-0.69864	0.576	0.205
hematology	white blood cell count (WBC; units per volume x 10³)	-0.30991	0.79277	-0.031441	0.828	0.699
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.0764	1.1416	-1.0328	0.758	0.359
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.84931	0.87881	1.4755	0.802	0.347
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.12174	0.52672	-0.093820	0.953	0.820
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.86087	0.94837	-0.80374	0.784	0.377
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.31304	0.60174	0.61679	0.908	0.610
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.13043	0.55475	-0.34941	0.970	0.817
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.66957	0.48086	1.5270	0.761	0.182
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.46087	0.53196	0.92128	0.828	0.398
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.25217	0.49563	-0.38423	0.925	0.617
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.27826	0.59136	0.77228	0.942	0.644
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.82609	0.48221	1.6868	0.673	0.105
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.26087	0.65385	0.53761	0.937	0.695
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.9922	0.80237	-1.8967	0.364	0.0238
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.81685	0.52246	1.2649	0.572	0.136
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.086901	0.59363	0.20727	0.971	0.885
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.10818	0.73241	0.11666	0.961	0.884
holeboard	total number of hole pokes, 20 min test	0.58606	4.3221	0.16265	0.950	0.894
light / dark	latency to enter dark zone, 20 min test	107.03	57.781	1.6329	0.486	0.0722
light / dark	number of transitions between light and dark zones, 20 min test	0.16200	8.7961	0.13016	0.993	0.985
light / dark	percentage of total time in dark zone, 20 min test	-2.0382	4.0496	-0.24303	0.861	0.618
light / dark	percentage of total time in light zone, 20 min test	2.0382	4.0496	0.23746	0.861	0.618
light / dark	time mobile in dark zone, 20 min test	8.8220	13.332	0.45309	0.770	0.512
light / dark	time mobile in light zone, 20 min test	21.811	12.390	0.95668	0.286	0.0871
light / dark	time spent in dark zone, 20 min test	-105.49	58.132	-1.2645	0.439	0.0779
light / dark	time spent in light zone, 20 min test	105.49	58.132	1.2645	0.439	0.0779
open field	average speed in center of arena, 20 min test	0.061571	0.43611	0.019469	0.968	0.889
open field	average speed in periphery of arena, 20 min test	0.43861	0.10653	1.1007	0.00449	0.000291
open field	distance traveled habituation ratio, 20 min test	-6.8827	7.0288	-0.56978	0.653	0.336
open field	distance traveled in center of arena, 20 min test	111.58	102.52	0.40339	0.539	0.285
open field	distance traveled in periphery of arena, 20 min test	401.45	111.16	1.0764	0.0157	0.00118
open field	distance traveled slope, 20 min test	-6.4534	6.8521	-0.56033	0.671	0.354
open field	distance traveled, 20 min test, 1st 5min	192.10	57.826	1.0958	0.0256	0.00242
open field	distance traveled, 20 min test, 2nd 5min	98.022	44.842	0.57928	0.162	0.0373
open field	distance traveled, 20 min test, 3rd 5min	84.500	42.610	0.50158	0.210	0.0569
open field	distance traveled, 20 min test, 4th 5min	133.70	31.364	0.98726	0.00444	0.000207
open field	number of clockwise revolution episodes, 20 min test	1.3143	0.93146	0.36098	0.517	0.169
open field	number of counter-clockwise revolution episodes, 20 min test	3.5019	0.91150	1.3781	0.0190	0.000641
open field	number of rears in 5 min bins, 20 min test, 1st 5min	4.4376	1.4252	0.98473	0.0541	0.00423
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	7.6000	2.8482	1.4706	0.101	0.0123
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	5.7857	2.8860	1.0049	0.232	0.0544
open field	number of rears in 5 min bins, 20 min test, 4th 5min	6.8441	2.6172	1.1698	0.122	0.0140
open field	percentage of total time in center of arena, 20 min test	1.8167	4.1902	0.21993	0.871	0.668
open field	percentage of total time in center of arena, slope, 20 min test	-0.72671	1.7694	-0.27810	0.934	0.684
open field	percentage of total time in center, habituation ratio, 20 min test	-0.91486	1.6028	-0.34863	0.880	0.573
open field	percentage of total time in corners of arena, 20 min test	-2.7444	5.4987	-0.18977	0.841	0.621
open field	percentage of total time in corners, habituation ratio, 20 min test	0.75951	2.1123	0.067853	0.947	0.722
open field	percentage of total time in corners, slope, 20 min test	1.1564	1.9847	0.24476	0.902	0.565
open field	permanence time in center of arena, 20 min test	21.801	50.283	0.21993	0.872	0.668
open field	permanence time in corners of arena, 20 min test	-32.916	65.983	-0.18977	0.842	0.622
open field	permanence time in periphery of arena, 20 min test	-21.784	50.288	-0.21993	0.872	0.668
open field	total distance traveled, 20 min test	499.29	128.42	0.89526	0.00738	0.000542
open field	total number of rears, 20 min test	24.357	8.2284	1.2776	0.0550	0.00607
open field	whole arena average speed, 20 min test	0.41600	0.10684	0.89326	0.00729	0.000533
open field	whole arena resting time, 20 min test	-45.280	14.846	-0.67575	0.0323	0.00485
open field	whole arena time spent mobile, 20 min test	45.220	14.864	0.91549	0.0346	0.00495
open field	whole arena time spent vertical, 20 min test	23.773	7.8268	1.5778	0.0668	0.00501
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.057829	1.5557	0.16207	0.992	0.971
startle / PPI	average baseline movement during background noise	0.52908	1.5084	0.43278	0.948	0.728
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.14227	0.064334	-1.3797	0.261	0.0334
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.14046	0.060357	-1.4476	0.229	0.0259
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-14.274	7.7597	-1.4562	0.813	0.0743
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-15.935	6.2836	-1.5852	0.231	0.0158
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-14.939	5.9599	-1.4767	0.142	0.0168
startle / PPI	average startle response to full pulse (120 dB)	-32.558	36.790	-0.43124	0.628	0.382
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	15.630	43.949	0.53197	0.866	0.724
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	26.928	38.001	0.76388	0.681	0.483
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	20.159	30.902	0.66791	0.700	0.518
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	5.9894	4.8315	2.3454	0.748	0.223
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	3.8968	2.0449	1.7478	0.544	0.0647
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	4.7387	2.1926	1.5424	0.342	0.0376
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.14332	0.078122	-1.2439	0.772	0.0751
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.15179	0.066928	-1.3436	0.257	0.0296
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.12413	0.071033	-1.1118	0.284	0.0891
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-33.087	36.591	-0.44048	0.617	0.372
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	18.394	41.125	0.59103	0.825	0.657
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	23.174	37.826	0.68198	0.727	0.544
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	20.155	30.903	0.67317	0.704	0.519
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.13717	0.076573	-1.1226	0.753	0.0819
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.18980	0.074768	-1.5467	0.192	0.0157
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.13308	0.074375	-1.1544	0.273	0.0820
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-105.13	139.20	-0.37200	0.685	0.455
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	54.382	137.60	0.47785	0.843	0.695
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	86.243	148.91	0.66441	0.739	0.566
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	71.609	117.24	0.64014	0.725	0.545
startle / PPI	maximum baseline movement during background noise	0.97167	3.3855	0.39917	0.960	0.776
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-15.204	7.9243	-1.3833	0.778	0.0632
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-19.503	7.2656	-1.7811	0.186	0.0110
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-15.602	6.6441	-1.5066	0.161	0.0245
startle / PPI	maximum startle response to full pulse (120 dB)	-104.16	139.29	-0.36900	0.690	0.459
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	71.764	154.80	0.55634	0.815	0.646
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	95.920	149.67	0.70336	0.709	0.526
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	84.336	116.68	0.72142	0.665	0.474
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	48.234	40.159	3.0570	0.727	0.238
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	9.6775	5.1764	1.8312	0.554	0.0697
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	13.799	5.8385	1.7414	0.252	0.0238

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	5.0 %	0.344
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	6.0 %	0.0277
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	29.0 %	0.0000855
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	5.0 %	0.435
eye morphology	lacrimation	30.0 %	0.0000182
eye morphology	lens	30.0 %	0.000134
eye morphology	lens opacity	30.0 %	0.0000964
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	29.0 %	0.000223
eye morphology	persistence of hyaloid vascular system	29.0 %	0.000250
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	5.0 %	0.461
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	29.0 %	0.000721
eye morphology	retinal blood vessels	29.0 %	0.000132
eye morphology	retinal blood vessels pattern	34.0 %	0.0000189
eye morphology	retinal blood vessels structure	29.0 %	0.000166
eye morphology	retinal pigmentation	29.0 %	0.000723
eye morphology	retinal structure	29.0 %	0.000197
eye morphology	synechia	30.0 %	0.0000661
eye morphology	vitreous	29.0 %	0.0000935
SHIRPA	activity body position	17.0 %	0.000890
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	12.0 %	0.00199
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	11.0 %	0.0618
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	12.0 %	0.00512
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.624
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	6.0 %	0.0575
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	17.0 %	0.000877
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	5.0 %	0.224
SHIRPA	vocalization	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Gbp7^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.