MPD: JaxKOMP-EAP genotype: Cwh43<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Cwh43^em1(IMPC)J/Mmjax -/- Gene Cwh43

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.46733	3.2343	-0.42284	0.967	0.887
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	0.24941	3.1440	0.065937	0.976	0.938
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.29700	2.9860	-0.11315	0.975	0.922
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	5.7718	4.5984	0.79481	0.612	0.224
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	9.2031	4.9946	1.3867	0.416	0.0803
body composition	body length	0.065203	0.061348	1.0596	0.600	0.301
body composition	body weight (at time of DXA)	-1.4071	1.0697	-0.88198	0.416	0.203
body composition	bone area, whole body scan, head excluded	0.20228	0.13860	1.0444	0.422	0.161
body composition	bone mineral content of whole body scan, head excluded	0.028710	0.010644	1.7472	0.102	0.0143
body composition	bone mineral content to body weight ratio	0.0011013	0.00041067	1.6130	0.0986	0.0148
body composition	bone mineral density of whole body scan, head excluded	0.0020472	0.00062589	1.9496	0.0580	0.00402
body composition	fat tissue mass of whole body scan, head excluded	-1.6057	0.45450	-2.3775	0.0335	0.00222
body composition	fat tissue mass to body weight ratio	-0.043946	0.015165	-1.9877	0.0675	0.00922
body composition	lean tissue mass of whole body scan, head excluded	0.83867	0.54610	1.3901	0.434	0.141
body composition	lean tissue mass to body weight ratio	0.045772	0.013548	2.0617	0.0432	0.00299
body composition	percent fat, whole body scan, head excluded	-4.1918	1.4161	-1.9977	0.0644	0.00804
body composition	ratio of soft-tissue attenuation coefficients	0.0046439	0.0015721	1.9968	0.0649	0.00815
body composition	tissue area	-0.20947	0.35924	-0.52001	0.822	0.567
body composition	total tissue mass, whole body scan, head excluded	-0.88841	0.43878	-2.3338	0.208	0.0572
clinical blood chemistry	alanine transaminase (plasma ALT)	-0.64327	3.8735	-0.077302	0.961	0.869
clinical blood chemistry	albumin (plasma Alb)	-0.33801	0.35142	-0.43073	0.653	0.344
clinical blood chemistry	alkaline phosphatase (plasma ALP)	1.1537	3.6402	-0.32517	0.885	0.754
clinical blood chemistry	aspartate transaminase (plasma AST)	-7.2391	8.3632	-0.36676	0.699	0.394
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.17710	0.18583	-0.55859	0.745	0.349
clinical blood chemistry	blood urea nitrogen (BUN)	2.9554	1.2698	1.1247	0.147	0.0274
clinical blood chemistry	calcium (plasma Ca)	-0.0012460	0.073944	0.34738	0.991	0.987
clinical blood chemistry	creatinine (plasma)	0.032562	0.020220	0.87229	0.328	0.119
clinical blood chemistry	glucose (plasma GLU, no fast)	-41.924	14.114	-1.1295	0.0382	0.00618
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.6616	2.2275	-0.89281	0.548	0.243
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.017014	0.010240	0.81792	0.413	0.108
clinical blood chemistry	phosphorus (plasma phosphate)	0.94973	0.42509	1.3596	0.182	0.0339
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0045066	0.0035417	0.30709	0.558	0.214
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-4.8706	3.5680	-1.0159	0.481	0.184
clinical blood chemistry	total protein (plasma TP)	-0.43884	0.46310	-0.40787	0.619	0.352
clinical blood chemistry	triglyceride (plasma TG, no fast)	-24.117	9.4652	-1.0557	0.127	0.0168
ERG v2.0	left eye a-wave amplitude (Photopic)	3.0493	2.0143	0.95001	0.544	0.150
ERG v2.0	left eye a-wave amplitude (Scotopic)	25.259	23.052	0.61847	0.647	0.289
ERG v2.0	left eye a-wave implicit timing (Photopic)	-1.5000	1.6443	-0.61847	0.809	0.375
ERG v2.0	left eye a-wave implicit timing (Scotopic)	-1.0417	0.95625	-0.87499	0.771	0.292
ERG v2.0	left eye b-wave amplitude (Photopic)	-5.9132	12.599	-0.70236	0.907	0.645
ERG v2.0	left eye b-wave amplitude (Scotopic)	-30.308	48.427	-0.32807	0.842	0.540
ERG v2.0	left eye b-wave implicit timing (Photopic)	0.16667	3.9373	0.19360	0.982	0.967
ERG v2.0	left eye b-wave implicit timing (Scotopic)	-0.083091	7.8333	0.030305	0.996	0.992
ERG v2.0	left eye c-wave amplitude (Scotopic)	-54.346	36.306	-0.80460	0.543	0.154
ERG v2.0	left eye c-wave implicit timing (Scotopic)	-70.521	95.970	-0.75249	0.809	0.473
ERG v2.0	left eye FO-like wave amplitude (Scotopic)	81.612	51.458	0.91603	0.546	0.132
ERG v2.0	left eye FO-like wave implicit timing (Scotopic)	-215.00	197.88	-0.65218	0.815	0.294
ERG v2.0	right eye a-wave amplitude (Photopic)	-0.92050	1.9536	-0.27269	0.907	0.644
ERG v2.0	right eye a-wave amplitude (Scotopic)	16.567	22.630	0.38888	0.833	0.475
ERG v2.0	right eye a-wave implicit timing (Photopic)	0.69517	1.2575	0.34556	0.939	0.589
ERG v2.0	right eye a-wave implicit timing (Scotopic)	-1.2328	0.73422	-1.0280	0.530	0.113
ERG v2.0	right eye b-wave amplitude (Photopic)	-14.650	10.521	-1.3549	0.623	0.183
ERG v2.0	right eye b-wave amplitude (Scotopic)	15.467	47.044	0.47335	0.965	0.747
ERG v2.0	right eye b-wave implicit timing (Photopic)	-2.7987	3.0314	-0.46721	0.711	0.370
ERG v2.0	right eye b-wave implicit timing (Scotopic)	-10.000	7.9552	-0.97624	0.749	0.227
ERG v2.0	right eye c-wave amplitude (Scotopic)	-13.632	41.594	-0.016492	0.944	0.747
ERG v2.0	right eye c-wave implicit timing (Scotopic)	-115.08	107.54	-1.1280	0.751	0.300
ERG v2.0	right eye FO-like wave amplitude (Scotopic)	17.142	55.918	0.0	0.933	0.763
ERG v2.0	right eye FO-like wave implicit timing (Scotopic)	-96.958	161.44	-0.18800	0.906	0.557
glucose tolerance test	amount glucose injected	-0.82152	1.8052	0.10262	0.881	0.653
glucose tolerance test	plasma glucose, 0min	-11.137	3.7607	-1.1617	0.0429	0.00663
glucose tolerance test	plasma glucose, 15min	-9.2916	16.838	-0.15714	0.837	0.586
glucose tolerance test	plasma glucose, 30min	-1.9483	23.352	0.082458	0.974	0.934
glucose tolerance test	plasma glucose, 60min	-8.7881	19.781	-0.24966	0.876	0.661
glucose tolerance test	plasma glucose, 120min	-12.562	7.5173	-0.97475	0.398	0.107
grip strength	body weight (at time of grip strength test)	-0.019375	0.49061	0.20006	0.984	0.969
grip strength	forelimb and hindlimb grip strength (mean of trials), average	2.4047	6.0773	0.41537	0.835	0.694
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.099444	0.22202	0.32974	0.805	0.657
grip strength	forelimb and hindlimb grip strength by trial, trial1	-8.3338	7.2908	-0.32820	0.560	0.260
grip strength	forelimb and hindlimb grip strength by trial, trial2	6.8924	6.9700	0.70117	0.583	0.329
grip strength	forelimb and hindlimb grip strength by trial, trial3	10.266	7.3431	0.88634	0.426	0.170
grip strength	forelimb grip strength (mean of trials), average	-3.8687	3.8454	-0.22853	0.583	0.320
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.084395	0.19179	0.021786	0.847	0.662
grip strength	forelimb grip strength by trial, trial1	-2.9373	5.3011	-0.074134	0.823	0.583
grip strength	forelimb grip strength by trial, trial2	-1.5473	4.4069	0.045036	0.904	0.727
grip strength	forelimb grip strength by trial, trial3	-2.4290	5.1735	0.0043568	0.853	0.641
heart weight	heart weight, normalized to body weight	0.088498	0.14927	-0.12396	0.734	0.557
heart weight	heart weight, weight	7.7347	3.9107	0.63390	0.197	0.0554
hematology	basophil differential (percent of total WBC)	0.0058333	0.044225	0.12386	0.982	0.896
hematology	calculated hemoglobin (cHGB)	-0.17436	0.12264	-0.79879	0.435	0.166
hematology	eosinophil differential (percent of total WBC)	0.0033333	0.19429	0.081456	0.992	0.986
hematology	hematocrit (HCT)	0.087120	0.31948	-0.29108	0.893	0.787
hematology	hemoglobin concentration distribution width (HDW)	-0.018466	0.019221	-0.50970	0.645	0.345
hematology	large unstained cells (percent of total WBC)	0.21858	0.095873	1.3488	0.242	0.0302
hematology	lymphocyte differential (percent of total WBC)	-1.3167	0.57685	-0.60817	0.164	0.0303
hematology	mean corpuscular hemoglobin (CHr)	-0.081568	0.051813	-0.66454	0.325	0.126
hematology	mean platelet volume (MPV)	-0.0068124	0.11428	-0.24740	0.977	0.953
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.17251	0.076412	-0.65440	0.229	0.0317
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.60769	0.21222	-1.0053	0.111	0.00771
hematology	mean RBC corpuscular volume (MCV)	0.38312	0.18552	0.69262	0.168	0.0480
hematology	measured hemoglobin (mHGB)	-0.28117	0.12154	-0.85258	0.201	0.0280
hematology	monocyte differential (percent of total WBC)	0.080982	0.11855	0.49205	0.786	0.500
hematology	neutrophil differential (percent of total WBC)	0.85097	0.50222	0.45839	0.307	0.101
hematology	platelet count (PLT; units per volume x 10³)	-91.925	32.694	-1.0871	0.133	0.00875
hematology	RBC corpuscular distribution width (RDW)	0.20960	0.11402	0.75091	0.280	0.0763
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.45500	0.20964	-1.1954	0.164	0.0383
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.058060	0.071013	-0.58927	0.673	0.420
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-3.8567	15.933	-0.087328	0.946	0.810
hematology	reticulocyte differential (percent of total RBC)	-0.0074218	0.14635	0.17980	0.982	0.960
hematology	white blood cell count (WBC; units per volume x 10³)	-1.7082	0.59833	-0.99320	0.0484	0.00787
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.22941	1.0141	-0.17560	0.946	0.823
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.21676	0.39270	-0.19965	0.890	0.586
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.72131	0.43104	1.1491	0.635	0.106
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.70588	0.90397	-0.64355	0.820	0.442
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.12320	0.53737	0.31664	0.965	0.820
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.36762	0.30369	0.96384	0.834	0.237
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.0058824	0.26254	-0.043115	1.00	0.982
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.22073	0.55704	-0.25683	0.942	0.695
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.13017	0.46263	-0.15090	0.964	0.781
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.25294	0.39355	0.70561	0.908	0.526
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.34104	0.28276	-0.90799	0.805	0.238
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.51594	0.46607	0.92174	0.721	0.278
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.64118	1.1006	-0.56115	0.857	0.565
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.24074	0.64604	0.48000	0.914	0.712
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.47647	0.64272	-0.68405	0.844	0.465
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.080408	0.72453	0.086135	0.969	0.912
holeboard	total number of hole pokes, 20 min test	-0.64190	4.4941	0.011808	0.947	0.888
light / dark	latency to enter dark zone, 20 min test	89.862	88.444	1.3918	0.718	0.319
light / dark	number of transitions between light and dark zones, 20 min test	-1.8000	7.7024	-0.058169	0.924	0.817
light / dark	percentage of total time in dark zone, 20 min test	4.2869	3.5929	0.87444	0.611	0.244
light / dark	percentage of total time in light zone, 20 min test	-4.2869	3.5929	-0.88439	0.611	0.244
light / dark	time mobile in dark zone, 20 min test	-11.195	16.628	-0.80332	0.764	0.506
light / dark	time mobile in light zone, 20 min test	-3.5174	11.572	-0.50004	0.889	0.763
light / dark	time spent in dark zone, 20 min test	-43.236	80.923	-0.43667	0.871	0.598
light / dark	time spent in light zone, 20 min test	43.236	80.923	0.43667	0.871	0.598
open field	average speed in center of arena, 20 min test	0.035264	0.59408	-0.028870	0.991	0.953
open field	average speed in periphery of arena, 20 min test	-0.098309	0.20826	-0.90331	0.803	0.643
open field	distance traveled habituation ratio, 20 min test	3.6066	9.5878	0.33297	0.881	0.711
open field	distance traveled in center of arena, 20 min test	87.007	159.75	0.21581	0.774	0.593
open field	distance traveled in periphery of arena, 20 min test	-142.25	223.59	-1.0049	0.742	0.533
open field	distance traveled slope, 20 min test	1.4405	8.4922	0.21581	0.966	0.867
open field	distance traveled, 20 min test, 1st 5min	-21.921	76.339	-0.52764	0.903	0.777
open field	distance traveled, 20 min test, 2nd 5min	5.1679	77.357	-0.43712	0.973	0.947
open field	distance traveled, 20 min test, 3rd 5min	-49.075	89.621	-1.0094	0.786	0.591
open field	distance traveled, 20 min test, 4th 5min	9.3259	76.638	-0.35291	0.966	0.905
open field	number of clockwise revolution episodes, 20 min test	-0.57030	1.5458	-0.75515	0.898	0.717
open field	number of counter-clockwise revolution episodes, 20 min test	1.2109	1.5118	0.22406	0.695	0.434
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.7055	2.5112	-1.2301	0.408	0.157
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.50566	3.1551	-0.48944	0.949	0.874
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-0.86604	4.7150	-0.48944	0.932	0.856
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-0.80972	4.2648	-0.52918	0.926	0.852
open field	percentage of total time in center of arena, 20 min test	3.6132	6.8928	0.63088	0.850	0.607
open field	percentage of total time in center of arena, slope, 20 min test	-1.1697	1.2982	-0.53382	0.808	0.380
open field	percentage of total time in center, habituation ratio, 20 min test	-0.95001	1.6776	-0.37875	0.881	0.578
open field	percentage of total time in corners of arena, 20 min test	-2.9764	7.5499	-0.22268	0.880	0.698
open field	percentage of total time in corners, habituation ratio, 20 min test	4.1805	3.9125	1.5072	0.787	0.300
open field	percentage of total time in corners, slope, 20 min test	4.2828	3.5187	1.6064	0.732	0.240
open field	permanence time in center of arena, 20 min test	43.369	82.719	0.63252	0.851	0.606
open field	permanence time in corners of arena, 20 min test	-35.732	90.600	-0.22268	0.881	0.698
open field	permanence time in periphery of arena, 20 min test	-43.409	82.720	-0.63252	0.850	0.606
open field	total distance traveled, 20 min test	-59.885	270.18	-0.67238	0.914	0.827
open field	total number of rears, 20 min test	-7.5328	12.388	-0.88132	0.753	0.551
open field	whole arena average speed, 20 min test	-0.053146	0.22513	-0.69102	0.908	0.816
open field	whole arena resting time, 20 min test	19.501	28.484	1.1106	0.689	0.502
open field	whole arena time spent mobile, 20 min test	-19.346	28.473	-1.3149	0.696	0.505
open field	whole arena time spent vertical, 20 min test	-11.188	12.186	-0.96564	0.672	0.371
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.8116	1.2537	-0.99969	0.203	0.0305
startle / PPI	average baseline movement during background noise	1.9046	1.2644	1.1412	0.685	0.141
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.14403	0.079080	1.1520	0.379	0.0766
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.13812	0.073603	1.2494	0.351	0.0685
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	6.4213	7.4479	0.73236	0.879	0.394
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	16.116	7.2456	1.6365	0.295	0.0323
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	16.102	7.3205	1.5611	0.201	0.0342
startle / PPI	average startle response to full pulse (120 dB)	-91.221	41.424	-1.2973	0.145	0.0340
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-113.81	41.946	-1.5517	0.0614	0.0101
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-117.68	33.666	-1.7675	0.0149	0.00125
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-96.538	32.538	-1.7414	0.0423	0.00525
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.62497	1.6566	0.49362	0.946	0.708
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	2.0501	1.4569	1.0690	0.677	0.168
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	4.1822	1.5224	1.3833	0.196	0.00923
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.047315	0.082368	0.49045	0.922	0.569
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.16853	0.085934	1.3576	0.322	0.0574
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.20228	0.081798	1.3439	0.121	0.0181
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-92.886	41.989	-1.3038	0.142	0.0332
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-114.83	42.470	-1.5658	0.0628	0.0103
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-120.14	33.798	-1.7675	0.0134	0.00106
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-100.98	32.494	-1.7811	0.0318	0.00361
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.037728	0.086592	0.35852	0.940	0.666
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.18885	0.093725	1.4090	0.301	0.0512
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.20850	0.083600	1.3235	0.117	0.0172
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-298.42	146.82	-1.1967	0.179	0.0493
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-367.21	153.89	-1.4093	0.0994	0.0223
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-421.72	128.43	-1.7414	0.0209	0.00225
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-348.49	122.03	-1.7043	0.0495	0.00700
startle / PPI	maximum baseline movement during background noise	4.2840	2.9698	1.1439	0.654	0.158
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.4292	8.2236	0.58271	0.921	0.513
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	18.293	8.4612	1.6473	0.304	0.0372
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	17.598	7.8391	1.4979	0.186	0.0308
startle / PPI	maximum startle response to full pulse (120 dB)	-294.51	145.35	-1.1853	0.181	0.0500
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-367.90	152.09	-1.4131	0.0964	0.0206
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-415.68	128.20	-1.7351	0.0222	0.00251
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-337.08	122.07	-1.6365	0.0578	0.00891
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-2.2419	8.4646	-0.61794	0.958	0.793
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	5.2901	3.4730	1.2259	0.629	0.136
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	10.248	3.6963	1.3339	0.168	0.00866

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	4.0 %	0.428
eye morphology	cornea vascularization	6.0 %	0.234
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	5.0 %	0.292
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	9.0 %	1.0
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	9.0 %	0.00456
eye morphology	persistence of hyaloid vascular system	6.0 %	0.247
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	5.0 %	0.461
eye morphology	pupil shape	5.0 %	0.342
eye morphology	retina	9.0 %	0.282
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
SHIRPA	activity body position	37.0 %	2.20e-9
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	37.0 %	6.47e-11
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	11.0 %	0.106
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	37.0 %	2.97e-9
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Cwh43^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.