MPD: JaxKOMP-EAP genotype: Ankrd52<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Ankrd52^em1(IMPC)J/Mmjax -/+ Gene Ankrd52

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	2.5621	5.4544	0.52110	0.892	0.645
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	1.4673	3.2410	0.35218	0.902	0.657
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.2500	6.3425	0.11172	0.951	0.846
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.6901	7.0594	-0.37828	0.931	0.814
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	7.4902	6.1970	1.1463	0.637	0.247
body composition	body length	-0.056837	0.044160	-0.46770	0.510	0.212
body composition	body weight (at time of DXA)	-0.38719	1.2619	-0.21659	0.880	0.762
body composition	bone area, whole body scan, head excluded	-0.51543	0.17320	-1.6333	0.0665	0.00721
body composition	bone mineral content of whole body scan, head excluded	-0.038803	0.0099416	-1.6763	0.0186	0.000819
body composition	bone mineral content to body weight ratio	-0.0016509	0.00037375	-1.6707	0.00721	0.000240
body composition	bone mineral density of whole body scan, head excluded	-0.0014543	0.00055677	-1.3686	0.126	0.0163
body composition	fat tissue mass of whole body scan, head excluded	0.73671	0.35061	1.0755	0.203	0.0479
body composition	fat tissue mass to body weight ratio	0.035048	0.010931	1.4046	0.0423	0.00424
body composition	lean tissue mass of whole body scan, head excluded	-0.89133	0.37324	-1.7286	0.176	0.0264
body composition	lean tissue mass to body weight ratio	-0.028651	0.010949	-1.4576	0.116	0.0161
body composition	percent fat, whole body scan, head excluded	3.4064	1.0140	1.4861	0.0349	0.00297
body composition	ratio of soft-tissue attenuation coefficients	-0.0037854	0.0011267	-1.4891	0.0345	0.00297
body composition	tissue area	0.026554	0.32925	0.27827	0.983	0.936
body composition	total tissue mass, whole body scan, head excluded	-0.25464	0.33568	-0.83232	0.691	0.457
clinical blood chemistry	alanine transaminase (plasma ALT)	-6.0417	5.8196	-0.56500	0.673	0.310
clinical blood chemistry	albumin (plasma Alb)	1.4167	0.43269	1.9693	0.0558	0.00321
clinical blood chemistry	alkaline phosphatase (plasma ALP)	0.66667	3.0402	-0.40701	0.920	0.828
clinical blood chemistry	aspartate transaminase (plasma AST)	-16.625	17.092	-0.77212	0.659	0.340
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.15104	0.19292	0.51109	0.803	0.441
clinical blood chemistry	blood urea nitrogen (BUN)	0.63286	1.0504	0.22327	0.763	0.553
clinical blood chemistry	calcium (plasma Ca)	0.16132	0.075891	1.4091	0.178	0.0440
clinical blood chemistry	creatinine (plasma)	-0.016314	0.016134	-0.28257	0.568	0.322
clinical blood chemistry	glucose (plasma GLU, no fast)	38.385	12.860	1.7722	0.0386	0.00643
clinical blood chemistry	HDL cholesterol (plasma HDL)	10.582	3.3353	1.9431	0.0653	0.00410
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.036848	0.011935	1.7090	0.0859	0.00520
clinical blood chemistry	phosphorus (plasma phosphate)	-0.20000	0.17565	-0.38325	0.553	0.266
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.028333	0.0093571	-1.7616	0.0847	0.00581
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	9.5833	3.9599	1.2602	0.152	0.0235
clinical blood chemistry	total protein (plasma TP)	1.7500	0.78581	1.2516	0.210	0.0356
clinical blood chemistry	triglyceride (plasma TG, no fast)	-29.968	8.0783	-1.2503	0.0331	0.00115
glucose tolerance test	amount glucose injected	7.1124	8.2511	1.8177	0.741	0.398
glucose tolerance test	plasma glucose, 0min	-10.000	4.2947	-1.0893	0.117	0.0300
glucose tolerance test	plasma glucose, 15min	-36.775	24.763	-0.88182	0.453	0.152
glucose tolerance test	plasma glucose, 30min	-25.027	12.248	-0.65991	0.280	0.0538
glucose tolerance test	plasma glucose, 60min	-61.588	17.160	-2.1906	0.0473	0.00163
glucose tolerance test	plasma glucose, 120min	-22.172	9.9034	-1.5761	0.243	0.0356
grip strength	body weight (at time of grip strength test)	-0.055625	0.74889	0.16025	0.967	0.941
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-30.865	6.0292	-1.8075	0.00128	0.0000395
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.4964	0.30246	-1.8226	0.00208	0.0000532
grip strength	forelimb and hindlimb grip strength by trial, trial1	-39.901	10.582	-2.1684	0.0211	0.00105
grip strength	forelimb and hindlimb grip strength by trial, trial2	-30.565	10.397	-1.6695	0.0665	0.00758
grip strength	forelimb and hindlimb grip strength by trial, trial3	-22.128	7.8262	-1.1753	0.0805	0.00981
grip strength	forelimb grip strength (mean of trials), average	-15.700	3.9570	-1.5673	0.0147	0.000653
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.76874	0.18813	-1.5014	0.0132	0.000489
grip strength	forelimb grip strength by trial, trial1	-19.795	5.6391	-1.8303	0.0501	0.00197
grip strength	forelimb grip strength by trial, trial2	-16.912	6.0361	-1.4881	0.106	0.0101
grip strength	forelimb grip strength by trial, trial3	-10.562	7.2483	-0.86082	0.457	0.159
heart weight	heart weight, normalized to body weight	0.028979	0.069575	-0.34954	0.825	0.681
heart weight	heart weight, weight	0.93113	2.2368	-0.24498	0.817	0.682
hematology	basophil differential (percent of total WBC)	0.033333	0.035316	0.53040	0.754	0.355
hematology	calculated hemoglobin (cHGB)	-0.062500	0.20044	-0.47438	0.884	0.758
hematology	eosinophil differential (percent of total WBC)	-0.29781	0.15962	-0.72916	0.402	0.0749
hematology	hematocrit (HCT)	0.57500	0.58491	0.27259	0.613	0.335
hematology	hemoglobin concentration distribution width (HDW)	-0.034152	0.021067	-0.94093	0.390	0.118
hematology	large unstained cells (percent of total WBC)	0.20349	0.073982	1.2788	0.173	0.0114
hematology	lymphocyte differential (percent of total WBC)	-0.010236	0.92196	-0.050592	0.993	0.991
hematology	mean corpuscular hemoglobin (CHr)	-0.13990	0.067992	-1.1204	0.181	0.0507
hematology	mean platelet volume (MPV)	0.42799	0.16342	1.5859	0.0739	0.0153
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.066875	0.078115	-0.27970	0.742	0.400
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.17429	0.17710	-0.39345	0.686	0.335
hematology	mean RBC corpuscular volume (MCV)	0.099323	0.18636	0.22185	0.784	0.599
hematology	measured hemoglobin (mHGB)	0.083333	0.18716	-0.032142	0.832	0.660
hematology	monocyte differential (percent of total WBC)	0.17352	0.16724	0.77308	0.659	0.310
hematology	neutrophil differential (percent of total WBC)	-0.078972	0.72342	-0.023237	0.961	0.914
hematology	platelet count (PLT; units per volume x 10³)	114.65	73.599	1.4652	0.499	0.133
hematology	RBC corpuscular distribution width (RDW)	-0.12500	0.12857	-0.43474	0.599	0.341
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.30660	0.18478	-0.84909	0.312	0.110
hematology	red blood cell count (RBC; per volume x 10⁶)	0.090417	0.15751	0.050647	0.773	0.571
hematology	reticulocyte count (Retic; units per volume x 10⁹)	0.75431	24.299	0.12878	0.992	0.975
hematology	reticulocyte differential (percent of total RBC)	-0.040542	0.21305	0.051652	0.938	0.851
hematology	white blood cell count (WBC; units per volume x 10³)	0.89674	0.77127	0.78418	0.461	0.256
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.1981	1.1574	1.1014	0.739	0.312
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.575	0.44328	1.0271	0.729	0.207
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.62500	0.36768	1.0271	0.633	0.103
holeboard	number of hole pokes by individual hole number, 20 min test, 4	2.2625	0.84135	1.9279	0.297	0.0131
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.65354	0.45079	1.0830	0.667	0.161
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.1875	0.33556	0.54346	0.930	0.582
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.5	0.44843	1.2712	0.835	0.276
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.725	0.58046	1.2720	0.752	0.224
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.7375	0.39043	1.2793	0.492	0.0716
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.10000	0.29415	0.33246	0.951	0.737
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.025000	0.37587	-0.050695	0.987	0.948
holeboard	number of hole pokes by individual hole number, 20 min test, 12	1.075	0.65506	1.5966	0.555	0.114
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.125	0.62847	1.1366	0.478	0.0866
holeboard	number of hole pokes by individual hole number, 20 min test, 14	1.3625	0.47175	1.9282	0.267	0.00830
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.21250	0.68778	-0.24882	0.914	0.760
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.0076036	0.87893	0.032055	0.998	0.993
holeboard	total number of hole pokes, 20 min test	10.912	4.1184	1.4091	0.131	0.0146
light / dark	fecal boli count, 20 min test	1.4875	0.88924	1.5163	0.499	0.108
light / dark	latency to enter dark zone, 20 min test	52.492	44.007	0.81457	0.662	0.245
light / dark	number of transitions between light and dark zones, 20 min test	6.8125	10.315	0.72545	0.772	0.516
light / dark	percentage of total time in dark zone, 20 min test	0.20288	2.9871	0.16433	0.985	0.946
light / dark	percentage of total time in light zone, 20 min test	-0.20287	2.9871	-0.17119	0.985	0.946
light / dark	time mobile in dark zone, 20 min test	4.1650	13.620	0.18355	0.899	0.763
light / dark	time mobile in light zone, 20 min test	2.5625	11.924	-0.079853	0.921	0.832
light / dark	time spent in dark zone, 20 min test	-43.990	52.562	-0.45159	0.766	0.411
light / dark	time spent in light zone, 20 min test	43.990	52.562	0.45159	0.766	0.411
open field	average speed in center of arena, 20 min test	-0.48212	0.46133	-0.99164	0.643	0.307
open field	average speed in periphery of arena, 20 min test	0.25887	0.18748	0.47436	0.385	0.181
open field	distance traveled habituation ratio, 20 min test	-11.635	12.293	-0.98945	0.668	0.354
open field	distance traveled in center of arena, 20 min test	9.8364	87.592	-0.32872	0.954	0.912
open field	distance traveled in periphery of arena, 20 min test	230.67	214.81	0.45790	0.535	0.294
open field	distance traveled slope, 20 min test	-12.525	11.688	-1.0909	0.622	0.295
open field	distance traveled, 20 min test, 1st 5min	165.58	107.37	0.92574	0.348	0.137
open field	distance traveled, 20 min test, 2nd 5min	38.350	64.373	-0.067853	0.762	0.557
open field	distance traveled, 20 min test, 3rd 5min	-23.187	63.273	-0.71335	0.871	0.717
open field	distance traveled, 20 min test, 4th 5min	60.098	64.559	0.19798	0.607	0.362
open field	number of clockwise revolution episodes, 20 min test	0.18750	1.6987	-0.29295	0.974	0.913
open field	number of counter-clockwise revolution episodes, 20 min test	0.21250	1.4356	-0.31740	0.952	0.884
open field	number of fecal boli, 20 min test	0.9375	0.80003	0.95230	0.586	0.253
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.5375	2.8164	0.48594	0.633	0.377
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.3180	3.6483	-0.68252	0.868	0.721
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.2764	3.6850	-0.015440	0.867	0.732
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.95253	4.3894	-0.15298	0.920	0.830
open field	percentage of total time in center of arena, 20 min test	1.6697	3.3465	0.19113	0.852	0.623
open field	percentage of total time in center of arena, slope, 20 min test	-1.0226	1.5299	-0.42680	0.863	0.511
open field	percentage of total time in center, habituation ratio, 20 min test	-0.70488	1.6627	-0.23785	0.904	0.676
open field	percentage of total time in corners of arena, 20 min test	-4.5271	4.8328	-0.52918	0.659	0.359
open field	percentage of total time in corners, habituation ratio, 20 min test	-2.0892	2.1413	-1.2837	0.805	0.339
open field	percentage of total time in corners, slope, 20 min test	-1.2784	2.0759	-0.91141	0.897	0.544
open field	permanence time in center of arena, 20 min test	20.037	40.153	0.19113	0.853	0.623
open field	permanence time in corners of arena, 20 min test	-54.321	57.992	-0.52918	0.659	0.359
open field	permanence time in periphery of arena, 20 min test	-20.020	40.151	-0.18977	0.853	0.623
open field	total distance traveled, 20 min test	241.81	239.83	0.21718	0.549	0.324
open field	total number of rears, 20 min test	3.4429	12.926	-0.10424	0.905	0.792
open field	whole arena average speed, 20 min test	0.20138	0.19940	0.21856	0.548	0.323
open field	whole arena resting time, 20 min test	-25.900	23.838	-0.18430	0.494	0.289
open field	whole arena time spent mobile, 20 min test	25.859	23.789	0.43269	0.502	0.288
open field	whole arena time spent vertical, 20 min test	3.1953	12.559	0.14076	0.920	0.802
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.5125	1.5268	0.82328	0.637	0.332
startle / PPI	average baseline movement during background noise	-1.4479	1.6464	-0.96333	0.849	0.388
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.20223	0.075958	1.6419	0.174	0.0139
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.22624	0.065119	2.0865	0.0705	0.00205
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	16.029	8.2485	1.9479	0.798	0.0643
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	20.662	6.8877	2.0995	0.157	0.00639
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	24.294	6.8969	2.3679	0.0495	0.00183
startle / PPI	average startle response to full pulse (120 dB)	-83.429	38.361	-1.1882	0.160	0.0402
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-134.38	41.280	-1.8164	0.0297	0.00348
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-107.84	31.332	-1.6528	0.0213	0.00222
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-88.546	24.429	-1.5902	0.0176	0.00142
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.72500	1.6490	0.55962	0.935	0.664
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	1.4750	1.5829	0.84923	0.844	0.361
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.80625	2.6650	0.21963	0.943	0.765
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.16929	0.092687	1.7043	0.782	0.0808
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.23093	0.074993	1.8382	0.120	0.00530
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.27849	0.081130	1.8461	0.0362	0.00227
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-81.981	38.580	-1.1602	0.167	0.0445
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-135.11	41.226	-1.8237	0.0283	0.00331
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-109.32	31.466	-1.6528	0.0197	0.00205
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-89.352	24.946	-1.6002	0.0185	0.00158
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.099385	0.12320	0.87155	0.891	0.428
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.23724	0.082229	1.7101	0.156	0.00836
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.27006	0.082698	1.6470	0.0461	0.00340
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-296.71	142.58	-1.1882	0.178	0.0488
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-454.67	153.20	-1.7414	0.0445	0.00689
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-411.40	116.32	-1.7164	0.0184	0.00176
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-324.86	90.502	-1.5902	0.0179	0.00155
startle / PPI	maximum baseline movement during background noise	-1.8437	3.3390	-0.50473	0.892	0.586
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	9.9817	11.375	1.0112	0.890	0.389
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	21.635	7.7325	1.9479	0.180	0.0102
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	24.484	7.5103	2.0628	0.0600	0.00345
startle / PPI	maximum startle response to full pulse (120 dB)	-298.55	142.44	-1.2083	0.177	0.0473
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-454.48	153.32	-1.7543	0.0455	0.00695
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-406.02	116.42	-1.6925	0.0192	0.00199
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-320.38	89.205	-1.5902	0.0177	0.00154
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.19375	3.4279	0.17676	0.989	0.955
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	5.3813	4.4257	1.2349	0.730	0.236
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	4.4771	7.7413	0.60107	0.843	0.569

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	23.0 %	0.00104
eye morphology	retinal blood vessels pattern	both	9.0 %	0.00872
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	25.0 %	0.00200
SHIRPA	activity body position	males	12.0 %	0.126
SHIRPA	activity body position	both	18.0 %	0.000585
SHIRPA	aggression	females	25.0 %	0.000778
SHIRPA	aggression	males	12.0 %	0.0522
SHIRPA	aggression	both	18.0 %	0.000109
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	12.0 %	0.00599
SHIRPA	hindlimb digit number	both	6.0 %	0.0100
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	12.0 %	0.00592
SHIRPA	hindpaw position	both	6.0 %	0.00589
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	12.0 %	0.00296
SHIRPA	hindpaw shape	both	6.0 %	0.00589
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	12.0 %	0.00296
SHIRPA	hindpaw size	both	6.0 %	0.00589
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	12.0 %	0.00365
SHIRPA	snout size	both	6.0 %	0.00430
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	24.0 %	0.00178
SHIRPA	transfer arousal	males	12.0 %	0.128
SHIRPA	transfer arousal	both	18.0 %	0.000390
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Ankrd52^em1(IMPC)J/Mmjax -/+ with genotype: