MPD: JaxKOMP-EAP genotype: Arhgap21<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Arhgap21^em1(IMPC)J/Mmjax -/+ Gene Arhgap21

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	17.5	14.866	2.0582	0.720	0.269
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	31.875	17.833	2.2253	0.457	0.108
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	14.375	11.553	1.8640	0.636	0.245
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	14.395	25.887	1.9667	0.839	0.593
body composition	body length	-0.23591	0.12187	-1.7258	0.279	0.0697
body composition	body weight (at time of DXA)	4.1259	1.3822	2.7198	0.0473	0.00794
body composition	bone area, whole body scan, head excluded	-0.74081	0.25853	-2.0735	0.0816	0.0107
body composition	bone mineral content of whole body scan, head excluded	-0.058041	0.020247	-2.2755	0.0862	0.0107
body composition	bone mineral content to body weight ratio	-0.0022562	0.00056836	-2.1635	0.0166	0.000990
body composition	bone mineral density of whole body scan, head excluded	-0.0020543	0.00093187	-1.8975	0.207	0.0416
body composition	fat tissue mass of whole body scan, head excluded	3.4178	0.52515	2.9413	0.000675	0.00000405
body composition	fat tissue mass to body weight ratio	0.098796	0.017185	2.9413	0.00145	0.0000189
body composition	lean tissue mass of whole body scan, head excluded	-2.1782	1.0122	-2.9413	0.237	0.0461
body composition	lean tissue mass to body weight ratio	-0.072116	0.016535	-2.6229	0.0142	0.000376
body composition	percent fat, whole body scan, head excluded	9.2334	1.6808	2.8511	0.00220	0.0000323
body composition	ratio of soft-tissue attenuation coefficients	-0.010264	0.0018683	-2.8504	0.00228	0.0000323
body composition	tissue area	1.1554	0.48540	2.7790	0.178	0.0293
body composition	total tissue mass, whole body scan, head excluded	0.98257	0.88252	1.6282	0.530	0.281
clinical blood chemistry	alanine transaminase (plasma ALT)	6.5101	1.9145	0.51095	0.0946	0.00257
clinical blood chemistry	albumin (plasma Alb)	0.69012	0.49167	1.0140	0.496	0.174
clinical blood chemistry	alkaline phosphatase (plasma ALP)	0.73186	3.5489	-0.39472	0.924	0.839
clinical blood chemistry	aspartate transaminase (plasma AST)	7.7775	3.5632	0.37435	0.261	0.0400
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.14279	0.11962	-0.44897	0.643	0.245
clinical blood chemistry	blood urea nitrogen (BUN)	-3.3369	1.2861	-1.2911	0.113	0.0169
clinical blood chemistry	calcium (plasma Ca)	0.13538	0.11663	1.2293	0.487	0.259
clinical blood chemistry	creatinine (plasma)	0.0025431	0.020223	0.16934	0.951	0.901
clinical blood chemistry	glucose (plasma GLU, no fast)	-0.17961	16.709	0.29636	0.994	0.992
clinical blood chemistry	HDL cholesterol (plasma HDL)	8.8328	3.5935	1.6418	0.165	0.0223
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.055676	0.012217	-2.4381	0.0121	0.000155
clinical blood chemistry	phosphorus (plasma phosphate)	0.59943	0.49599	0.85551	0.528	0.240
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.011791	0.0053229	-0.88531	0.223	0.0374
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	13.776	3.7618	1.8025	0.0311	0.00137
clinical blood chemistry	total protein (plasma TP)	1.6407	0.75230	1.1914	0.221	0.0402
clinical blood chemistry	triglyceride (plasma TG, no fast)	17.316	12.879	1.0759	0.479	0.192
glucose tolerance test	amount glucose injected	6.5012	7.4124	1.7502	0.741	0.388
glucose tolerance test	plasma glucose, 0min	8.7591	6.7580	0.66847	0.411	0.206
glucose tolerance test	plasma glucose, 15min	9.2520	24.896	0.37956	0.898	0.713
glucose tolerance test	plasma glucose, 30min	-32.018	20.946	-0.88385	0.458	0.138
glucose tolerance test	plasma glucose, 60min	-17.724	13.201	-0.62615	0.512	0.191
glucose tolerance test	plasma glucose, 120min	1.8866	12.152	0.0	0.953	0.878
grip strength	body weight (at time of grip strength test)	1.8533	0.63141	1.7651	0.0321	0.00634
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-9.6802	6.2344	-0.44725	0.302	0.131
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.40829	0.31385	-0.40117	0.400	0.204
grip strength	forelimb and hindlimb grip strength by trial, trial1	-7.8331	8.9404	-0.29770	0.677	0.388
grip strength	forelimb and hindlimb grip strength by trial, trial2	-17.716	7.7705	-0.87351	0.153	0.0302
grip strength	forelimb and hindlimb grip strength by trial, trial3	-2.9244	8.7958	0.0087138	0.891	0.742
grip strength	forelimb grip strength (mean of trials), average	-9.7364	4.3986	-0.90587	0.167	0.0346
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.51583	0.25255	-1.0437	0.214	0.0503
grip strength	forelimb grip strength by trial, trial1	-6.7255	4.6644	-0.51741	0.488	0.160
grip strength	forelimb grip strength by trial, trial2	-14.879	6.0815	-1.2802	0.164	0.0207
grip strength	forelimb grip strength by trial, trial3	-9.4260	5.9461	-0.75223	0.401	0.123
heart weight	heart weight, normalized to body weight	0.24016	0.37092	0.38277	0.712	0.525
heart weight	heart weight, weight	0.46050	9.0968	-0.31101	0.974	0.960
hematology	basophil differential (percent of total WBC)	0.049681	0.041496	0.75880	0.685	0.245
hematology	calculated hemoglobin (cHGB)	0.59542	0.32271	1.5236	0.292	0.0792
hematology	eosinophil differential (percent of total WBC)	-0.52297	0.36321	-1.3110	0.556	0.164
hematology	hematocrit (HCT)	2.6040	1.0283	2.0615	0.149	0.0194
hematology	hemoglobin concentration distribution width (HDW)	0.023265	0.034148	0.64531	0.747	0.503
hematology	large unstained cells (percent of total WBC)	0.086677	0.091711	0.55839	0.681	0.355
hematology	lymphocyte differential (percent of total WBC)	-0.87740	3.3224	-0.41628	0.908	0.794
hematology	mean corpuscular hemoglobin (CHr)	-0.0015418	0.067776	0.017283	0.991	0.982
hematology	mean platelet volume (MPV)	0.29949	0.24337	1.3059	0.449	0.232
hematology	mean RBC corpuscular hemoglobin (MCH)	0.010811	0.080114	0.011323	0.963	0.894
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.0087126	0.19395	0.039733	0.988	0.965
hematology	mean RBC corpuscular volume (MCV)	0.065859	0.27534	0.15230	0.919	0.813
hematology	measured hemoglobin (mHGB)	0.79015	0.31689	1.6982	0.180	0.0211
hematology	monocyte differential (percent of total WBC)	0.021164	0.28691	0.28680	0.978	0.942
hematology	neutrophil differential (percent of total WBC)	1.2733	2.6976	0.66679	0.809	0.642
hematology	platelet count (PLT; units per volume x 10³)	157.28	64.250	1.8730	0.220	0.0228
hematology	RBC corpuscular distribution width (RDW)	-0.36315	0.23713	-1.3195	0.378	0.141
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.16704	0.20631	-0.49664	0.682	0.427
hematology	red blood cell count (RBC; per volume x 10⁶)	0.35501	0.22972	1.2051	0.386	0.137
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-15.745	34.521	-0.60084	0.885	0.653
hematology	reticulocyte differential (percent of total RBC)	-0.27619	0.44951	-0.95830	0.810	0.545
hematology	white blood cell count (WBC; units per volume x 10³)	1.6605	0.80580	1.2766	0.168	0.0519
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.1422	1.1449	1.0620	0.739	0.327
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.32227	0.44759	0.62498	0.868	0.478
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.28600	0.49463	0.56850	0.908	0.568
holeboard	number of hole pokes by individual hole number, 20 min test, 4	2.0805	0.86194	1.8385	0.340	0.0228
holeboard	number of hole pokes by individual hole number, 20 min test, 5	1.1561	0.61713	1.6942	0.570	0.0723
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.30450	0.28173	0.83491	0.849	0.289
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.41114	0.39407	1.0406	0.842	0.306
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.14351	0.46195	-0.13630	0.960	0.758
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.45616	0.42611	0.90545	0.770	0.294
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.58286	0.30057	1.3808	0.664	0.0634
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.68483	0.36733	1.4802	0.653	0.0732
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.0076152	0.55239	0.096298	0.997	0.989
holeboard	number of hole pokes by individual hole number, 20 min test, 13	2.2322	0.70652	1.9617	0.238	0.00387
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.62322	0.47289	1.0162	0.641	0.199
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.34953	0.55346	-0.45367	0.863	0.533
holeboard	number of hole pokes by individual hole number, 20 min test, 16	2.0592	0.97708	1.6805	0.404	0.0445
holeboard	total number of hole pokes, 20 min test	11.416	3.7277	1.4659	0.0665	0.00493
light / dark	latency to enter dark zone, 20 min test	-37.076	65.259	-0.80706	0.863	0.573
light / dark	number of transitions between light and dark zones, 20 min test	-1.7698	6.5162	-0.056815	0.907	0.787
light / dark	percentage of total time in dark zone, 20 min test	3.3688	4.8183	0.71493	0.782	0.489
light / dark	percentage of total time in light zone, 20 min test	-3.3688	4.8183	-0.71668	0.780	0.489
light / dark	time mobile in dark zone, 20 min test	2.7484	14.417	0.085280	0.943	0.850
light / dark	time mobile in light zone, 20 min test	-7.3232	10.963	-0.78111	0.747	0.508
light / dark	time spent in dark zone, 20 min test	46.542	58.226	0.91891	0.785	0.429
light / dark	time spent in light zone, 20 min test	-46.542	58.226	-0.91891	0.785	0.429
open field	average speed in center of arena, 20 min test	0.79436	0.41152	1.2391	0.328	0.0611
open field	average speed in periphery of arena, 20 min test	0.53702	0.19211	1.3609	0.0508	0.00809
open field	distance traveled habituation ratio, 20 min test	-4.8483	8.1314	-0.37443	0.794	0.554
open field	distance traveled in center of arena, 20 min test	231.37	108.43	1.0388	0.168	0.0394
open field	distance traveled in periphery of arena, 20 min test	485.57	195.17	1.3442	0.0972	0.0173
open field	distance traveled slope, 20 min test	-4.9514	7.5049	-0.40193	0.776	0.513
open field	distance traveled, 20 min test, 1st 5min	175.86	72.488	1.0183	0.107	0.0201
open field	distance traveled, 20 min test, 2nd 5min	214.15	63.314	1.5731	0.0209	0.00168
open field	distance traveled, 20 min test, 3rd 5min	198.81	72.921	1.5114	0.0642	0.00963
open field	distance traveled, 20 min test, 4th 5min	156.15	84.016	1.1751	0.241	0.0708
open field	number of clockwise revolution episodes, 20 min test	1.3705	1.6040	0.39416	0.739	0.398
open field	number of counter-clockwise revolution episodes, 20 min test	1.4531	1.2431	0.34008	0.535	0.249
open field	number of fecal boli, 20 min test	1.025	1.6381	1.0119	0.791	0.541
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.0469	2.0650	0.36242	0.594	0.328
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	8.4007	2.7142	1.6212	0.0477	0.00363
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	4.8676	3.3249	0.81588	0.410	0.151
open field	number of rears in 5 min bins, 20 min test, 4th 5min	3.2009	3.7902	0.37587	0.672	0.404
open field	percentage of total time in center of arena, 20 min test	0.95560	3.4333	0.026184	0.919	0.782
open field	percentage of total time in center of arena, slope, 20 min test	1.1628	1.3685	0.77716	0.815	0.401
open field	percentage of total time in center, habituation ratio, 20 min test	1.7189	1.4803	1.0343	0.734	0.253
open field	percentage of total time in corners of arena, 20 min test	1.4929	3.7168	0.56978	0.877	0.690
open field	percentage of total time in corners, habituation ratio, 20 min test	1.5214	1.9151	0.40484	0.852	0.432
open field	percentage of total time in corners, slope, 20 min test	1.3907	1.7986	0.36867	0.859	0.444
open field	permanence time in center of arena, 20 min test	11.493	41.201	0.028870	0.920	0.782
open field	permanence time in corners of arena, 20 min test	17.921	44.603	0.56978	0.877	0.690
open field	permanence time in periphery of arena, 20 min test	-11.440	41.207	-0.026184	0.920	0.783
open field	total distance traveled, 20 min test	727.89	246.28	1.3956	0.0355	0.00534
open field	total number of rears, 20 min test	18.085	10.431	0.89326	0.287	0.0909
open field	whole arena average speed, 20 min test	0.60688	0.20538	1.3956	0.0356	0.00534
open field	whole arena resting time, 20 min test	-76.057	23.750	-1.3343	0.0207	0.00276
open field	whole arena time spent mobile, 20 min test	76.042	23.734	1.5199	0.0215	0.00274
open field	whole arena time spent vertical, 20 min test	14.803	10.267	1.0528	0.450	0.157
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.5107	1.3856	-0.45021	0.597	0.284
startle / PPI	average baseline movement during background noise	2.5089	2.3263	1.4018	0.796	0.294
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.0097949	0.10010	-0.17676	0.964	0.923
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.017166	0.090632	-0.24149	0.937	0.852
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.4498	7.9861	0.86542	0.879	0.362
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-10.696	8.7447	-1.0840	0.609	0.235
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.4095	7.8926	-0.62986	0.769	0.501
startle / PPI	average startle response to full pulse (120 dB)	48.789	76.498	1.1018	0.753	0.531
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	12.409	74.377	0.46220	0.944	0.869
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	40.286	68.057	0.98131	0.735	0.561
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	37.216	64.323	1.0277	0.738	0.570
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.53316	1.9280	0.43740	0.969	0.785
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.75690	3.0241	0.50155	0.961	0.805
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	5.6970	6.1694	1.8020	0.752	0.367
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.028891	0.090600	0.32879	0.957	0.753
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.10971	0.10468	-0.99888	0.641	0.307
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.022648	0.15630	-0.37147	0.949	0.886
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	48.482	77.971	1.1070	0.761	0.541
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	11.949	74.880	0.45287	0.945	0.875
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	37.895	67.847	0.93042	0.750	0.583
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	31.759	66.757	0.94128	0.785	0.640
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.068638	0.10064	0.65223	0.917	0.503
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.11281	0.10029	-0.95629	0.622	0.274
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.0048741	0.16965	-0.15057	0.991	0.977
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	390.15	264.67	1.7043	0.372	0.156
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	80.450	269.80	0.59772	0.891	0.769
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	162.65	240.59	1.0349	0.694	0.507
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	130.45	230.86	1.0159	0.740	0.579
startle / PPI	maximum baseline movement during background noise	8.4455	6.3022	1.7478	0.710	0.195
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	8.9005	9.2171	0.89222	0.890	0.346
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-10.196	9.1174	-0.98358	0.636	0.277
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-4.5570	9.1654	-0.54656	0.828	0.624
startle / PPI	maximum startle response to full pulse (120 dB)	396.13	261.92	1.7164	0.355	0.146
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	83.554	268.60	0.61456	0.888	0.759
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	166.68	241.40	1.0373	0.688	0.498
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	148.33	223.11	1.0865	0.696	0.514
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	3.0089	4.5590	0.88806	0.860	0.517
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.65712	6.9494	-0.17534	0.994	0.926
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	18.254	20.244	2.0628	0.744	0.378

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	11.0 %	0.257
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	6.0 %	0.326
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	12.0 %	0.146
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	6.0 %	0.132
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.00
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	12.0 %	0.0440
SHIRPA	activity body position	males	13.0 %	0.111
SHIRPA	activity body position	both	12.0 %	0.0169
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	12.0 %	0.0175
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	6.0 %	0.0592
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	47.0 %	0.000103
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	23.0 %	0.00165
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	23.0 %	0.0569
SHIRPA	limb grasp	both	6.0 %	0.299
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	13.0 %	0.113
SHIRPA	transfer arousal	both	12.0 %	0.0185
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	98.0 %	1.61e-7
SHIRPA	vocalization	males	98.0 %	0.00000802
SHIRPA	vocalization	both	98.0 %	1.25e-12

GENOTYPE CORRELATION PLOT

Correlate Arhgap21^em1(IMPC)J/Mmjax -/+ with genotype: