MPD: JaxKOMP-EAP genotype: Itfg2<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Itfg2^em1(IMPC)J/Mmjax -/+ Gene Itfg2

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	2.0192	3.4540	0.37603	0.858	0.571
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.1331	3.3793	-0.46309	0.861	0.541
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.096154	3.4912	-0.15471	0.995	0.979
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.45449	6.5091	-0.057032	0.983	0.946
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-6.6800	4.6961	-0.99925	0.570	0.183
body composition	body length	-0.11387	0.057049	-0.99221	0.267	0.0644
body composition	body weight (at time of DXA)	-0.13100	0.77517	-0.0088695	0.946	0.868
body composition	bone area, whole body scan, head excluded	-0.14123	0.15726	-0.37739	0.642	0.383
body composition	bone mineral content of whole body scan, head excluded	-0.018090	0.013552	-0.82846	0.477	0.202
body composition	bone mineral content to body weight ratio	-0.00066011	0.00061014	-0.66936	0.575	0.296
body composition	bone mineral density of whole body scan, head excluded	-0.00072580	0.0010900	-0.78458	0.759	0.515
body composition	fat tissue mass of whole body scan, head excluded	0.68777	0.45019	1.0143	0.371	0.147
body composition	fat tissue mass to body weight ratio	0.028281	0.015529	1.1868	0.259	0.0886
body composition	lean tissue mass of whole body scan, head excluded	-0.93397	0.49164	-1.7795	0.319	0.0769
body composition	lean tissue mass to body weight ratio	-0.029899	0.013091	-1.5153	0.177	0.0374
body composition	percent fat, whole body scan, head excluded	2.8593	1.4932	1.3087	0.242	0.0748
body composition	ratio of soft-tissue attenuation coefficients	-0.0031787	0.0016601	-1.3011	0.245	0.0748
body composition	tissue area	0.11729	0.18694	0.59018	0.807	0.540
body composition	total tissue mass, whole body scan, head excluded	-0.057747	0.19012	-0.35404	0.877	0.765
clinical blood chemistry	alanine transaminase (plasma ALT)	-0.31457	2.9548	-0.046068	0.974	0.916
clinical blood chemistry	albumin (plasma Alb)	-0.33714	0.67055	-0.42604	0.853	0.621
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-1.4979	2.5572	-0.79178	0.767	0.565
clinical blood chemistry	aspartate transaminase (plasma AST)	-6.0466	6.0002	-0.30822	0.646	0.326
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.078534	0.15880	-0.24369	0.875	0.627
clinical blood chemistry	blood urea nitrogen (BUN)	-0.55344	2.4882	-0.24389	0.920	0.826
clinical blood chemistry	calcium (plasma Ca)	-0.21439	0.046115	-1.2055	0.00519	0.000175
clinical blood chemistry	creatinine (plasma)	0.013885	0.069620	0.43971	0.917	0.844
clinical blood chemistry	glucose (plasma GLU, no fast)	-15.484	16.876	-0.30982	0.575	0.370
clinical blood chemistry	HDL cholesterol (plasma HDL)	-0.28130	3.9271	-0.40086	0.982	0.944
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.013850	0.013190	0.63263	0.635	0.307
clinical blood chemistry	phosphorus (plasma phosphate)	-0.55972	0.80443	-0.95648	0.749	0.495
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.027363	0.0050402	-1.7227	0.00344	0.0000308
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-3.9835	5.6963	-0.89468	0.768	0.493
clinical blood chemistry	total protein (plasma TP)	0.094766	1.0013	0.011420	0.969	0.926
clinical blood chemistry	triglyceride (plasma TG, no fast)	-9.9067	9.2150	-0.33524	0.587	0.296
EKG	duration of PQ interval	0.12368	1.3380	0.26710	0.984	0.929
EKG	duration of PR interval	-0.42632	1.0031	-0.33245	0.938	0.682
EKG	duration of QRS interval	-0.95263	0.78098	-2.5883	0.885	0.257
EKG	duration of QT interval	-0.61842	0.91908	-0.43663	0.898	0.520
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.17368	1.0477	-0.14559	0.991	0.872
EKG	duration of RR interval	-2.4605	1.6283	-1.0316	0.586	0.169
EKG	duration of ST interval	0.29474	1.1586	0.51794	0.960	0.806
EKG	heart rate coefficient of variation (signal intensity)	-2.3984	2.9745	-1.8966	0.877	0.443
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-15.639	21.776	-1.7969	0.887	0.493
EKG	heart rate, beats per min	17.500	12.383	0.79816	0.587	0.195
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.032632	0.15452	-0.37892	0.951	0.838
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.105	0.29876	-0.67639	0.908	0.734
EKG	number of signals	17.474	22.436	2.2304	0.862	0.459
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	0.39026	19.425	0.16143	0.997	0.984
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-9.2632	8.4779	-2.2817	0.894	0.306
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-10.805	9.7150	-2.3398	0.883	0.298
EKG	root mean square of successive differences of neighboring RR intervals	-5.6729	5.0063	-2.4072	0.843	0.290
glucose tolerance test	amount glucose injected	0.39656	2.2881	0.48674	0.957	0.864
glucose tolerance test	plasma glucose, 0min	11.709	4.0393	0.94430	0.0455	0.00720
glucose tolerance test	plasma glucose, 15min	64.739	15.511	1.7384	0.0179	0.000263
glucose tolerance test	plasma glucose, 30min	104.77	16.764	2.3755	0.000697	0.00000420
glucose tolerance test	plasma glucose, 60min	20.511	17.298	0.91053	0.581	0.246
glucose tolerance test	plasma glucose, 120min	23.664	6.3687	1.4278	0.0367	0.000896
grip strength	body weight (at time of grip strength test)	-0.61331	0.34384	-0.34623	0.206	0.0819
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-8.5181	7.3681	-0.38079	0.462	0.254
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.24046	0.42423	-0.13987	0.747	0.575
grip strength	forelimb and hindlimb grip strength by trial, trial1	-9.9070	8.6451	-0.44084	0.558	0.258
grip strength	forelimb and hindlimb grip strength by trial, trial2	-1.3014	8.7999	0.15455	0.941	0.883
grip strength	forelimb and hindlimb grip strength by trial, trial3	-14.126	9.1938	-0.70862	0.369	0.132
grip strength	forelimb grip strength (mean of trials), average	-3.3986	4.6403	-0.17811	0.711	0.468
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.0040509	0.19701	0.22704	0.997	0.984
grip strength	forelimb grip strength by trial, trial1	-0.98472	5.9106	0.17222	0.949	0.869
grip strength	forelimb grip strength by trial, trial2	-7.0327	8.2714	-0.55261	0.719	0.402
grip strength	forelimb grip strength by trial, trial3	-9.4138	6.4064	-0.74838	0.441	0.149
heart weight	heart weight, normalized to body weight	0.19778	0.14956	0.25614	0.411	0.198
heart weight	heart weight, weight	5.4573	3.2797	0.33521	0.282	0.108
hematology	basophil differential (percent of total WBC)	0.038462	0.055918	0.61285	0.827	0.500
hematology	calculated hemoglobin (cHGB)	-0.040160	0.26940	-0.41110	0.953	0.883
hematology	eosinophil differential (percent of total WBC)	-0.15166	0.23123	-0.34519	0.839	0.520
hematology	hematocrit (HCT)	-0.64605	0.72986	-0.96017	0.649	0.387
hematology	hemoglobin concentration distribution width (HDW)	0.055359	0.027556	1.4703	0.300	0.0582
hematology	large unstained cells (percent of total WBC)	-0.0012658	0.099671	0.028666	0.996	0.990
hematology	lymphocyte differential (percent of total WBC)	-2.2904	0.77124	-0.98207	0.0833	0.00787
hematology	mean corpuscular hemoglobin (CHr)	-0.089819	0.076823	-0.72617	0.491	0.256
hematology	mean platelet volume (MPV)	-0.26670	0.084981	-1.4592	0.0353	0.00541
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.11558	0.10835	-0.45121	0.653	0.299
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.60022	0.30041	1.1313	0.336	0.0595
hematology	mean RBC corpuscular volume (MCV)	-1.3642	0.27867	-1.7790	0.00179	0.000100
hematology	measured hemoglobin (mHGB)	0.23019	0.28423	0.35683	0.690	0.428
hematology	monocyte differential (percent of total WBC)	0.098271	0.29129	0.55476	0.905	0.740
hematology	neutrophil differential (percent of total WBC)	2.0023	0.53287	1.0045	0.0291	0.00133
hematology	platelet count (PLT; units per volume x 10³)	-64.027	34.556	-0.78977	0.395	0.0795
hematology	RBC corpuscular distribution width (RDW)	0.17090	0.15120	0.58792	0.538	0.272
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.80592	0.30445	1.7475	0.0936	0.0155
hematology	red blood cell count (RBC; per volume x 10⁶)	0.063863	0.15988	-0.061610	0.852	0.694
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-62.147	30.657	-2.1611	0.378	0.0562
hematology	reticulocyte differential (percent of total RBC)	-0.70507	0.30372	-2.1882	0.284	0.0309
hematology	white blood cell count (WBC; units per volume x 10³)	1.1381	1.0167	0.92187	0.482	0.277
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.015509	0.72322	0.034610	0.997	0.983
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.13969	0.43951	-0.088734	0.950	0.752
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.20401	0.38009	0.41044	0.908	0.594
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.73750	0.75402	-0.67502	0.763	0.334
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.71735	0.50403	-1.0770	0.667	0.165
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.12432	0.30970	-0.31908	0.949	0.690
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.22136	0.25465	0.60348	0.884	0.390
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-1.3093	0.66835	-2.1082	0.541	0.0569
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.0041667	0.36007	0.11511	0.995	0.991
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.19636	0.29598	0.56481	0.904	0.511
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.29167	0.26589	0.71317	0.807	0.279
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.34583	0.83372	-0.50284	0.934	0.680
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.67917	0.70280	0.75845	0.738	0.340
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.42303	0.44202	0.74280	0.744	0.344
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.082763	0.49985	-0.032055	0.963	0.869
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.19985	0.85368	-0.16436	0.948	0.816
holeboard	total number of hole pokes, 20 min test	-2.3805	3.7991	-0.23146	0.760	0.534
light / dark	fecal boli count, 20 min test	0.29090	0.55763	0.34974	0.865	0.606
light / dark	latency to enter dark zone, 20 min test	13.631	33.245	0.15611	0.907	0.684
light / dark	number of transitions between light and dark zones, 20 min test	14.690	8.0884	1.3743	0.341	0.0768
light / dark	percentage of total time in dark zone, 20 min test	-3.0809	2.4641	-0.42332	0.594	0.218
light / dark	percentage of total time in light zone, 20 min test	3.0809	2.4641	0.41889	0.594	0.218
light / dark	time mobile in dark zone, 20 min test	12.902	11.421	0.65677	0.566	0.265
light / dark	time mobile in light zone, 20 min test	5.9602	10.336	0.16433	0.785	0.567
light / dark	time spent in dark zone, 20 min test	-39.096	41.730	-0.37500	0.734	0.354
light / dark	time spent in light zone, 20 min test	39.096	41.730	0.37500	0.734	0.354
open field	average speed in center of arena, 20 min test	0.13642	0.35298	0.15842	0.891	0.702
open field	average speed in periphery of arena, 20 min test	0.30498	0.16490	0.64569	0.213	0.0743
open field	distance traveled habituation ratio, 20 min test	-0.91025	7.4075	-0.030213	0.955	0.903
open field	distance traveled in center of arena, 20 min test	250.33	105.38	1.1487	0.122	0.0223
open field	distance traveled in periphery of arena, 20 min test	78.050	165.25	-0.11640	0.806	0.639
open field	distance traveled slope, 20 min test	-3.4118	7.1264	-0.23923	0.851	0.635
open field	distance traveled, 20 min test, 1st 5min	93.683	74.696	0.42533	0.463	0.217
open field	distance traveled, 20 min test, 2nd 5min	113.50	60.850	0.73253	0.234	0.0693
open field	distance traveled, 20 min test, 3rd 5min	35.733	48.651	-0.032900	0.706	0.467
open field	distance traveled, 20 min test, 4th 5min	85.483	53.485	0.47436	0.316	0.118
open field	number of clockwise revolution episodes, 20 min test	2.3708	1.1311	0.90496	0.256	0.0423
open field	number of counter-clockwise revolution episodes, 20 min test	1.4833	1.2539	0.36293	0.530	0.244
open field	number of fecal boli, 20 min test	-0.91146	1.0947	-0.46159	0.708	0.410
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.1331	1.6383	0.65689	0.251	0.0628
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	4.9613	1.5523	0.95287	0.0397	0.00268
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	4.2180	1.9746	0.67070	0.194	0.0387
open field	number of rears in 5 min bins, 20 min test, 4th 5min	3.3288	1.8875	0.39612	0.311	0.0853
open field	percentage of total time in center of arena, 20 min test	7.1830	3.5226	1.3609	0.282	0.0503
open field	percentage of total time in center of arena, slope, 20 min test	2.4672	1.4402	1.4907	0.550	0.0970
open field	percentage of total time in center, habituation ratio, 20 min test	2.3804	1.4963	1.4284	0.573	0.122
open field	percentage of total time in corners of arena, 20 min test	-12.079	4.0958	-1.8213	0.0872	0.00612
open field	percentage of total time in corners, habituation ratio, 20 min test	-3.3291	2.1299	-1.8006	0.610	0.126
open field	percentage of total time in corners, slope, 20 min test	-2.7809	2.0511	-1.6415	0.671	0.183
open field	permanence time in center of arena, 20 min test	86.193	42.268	1.3575	0.283	0.0503
open field	permanence time in corners of arena, 20 min test	-144.93	49.150	-1.8213	0.0873	0.00613
open field	permanence time in periphery of arena, 20 min test	-86.207	42.262	-1.3609	0.282	0.0503
open field	total distance traveled, 20 min test	328.38	201.00	0.45492	0.277	0.110
open field	total number of rears, 20 min test	15.600	5.4585	0.71855	0.0590	0.00667
open field	whole arena average speed, 20 min test	0.27354	0.16748	0.45492	0.278	0.110
open field	whole arena resting time, 20 min test	-36.680	21.470	-0.46387	0.251	0.0979
open field	whole arena time spent mobile, 20 min test	36.752	21.451	0.71682	0.250	0.0970
open field	whole arena time spent vertical, 20 min test	9.6588	5.0685	0.63909	0.293	0.0637
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	2.9368	1.4433	1.3594	0.250	0.0484
startle / PPI	average baseline movement during background noise	0.10949	1.5137	0.17107	0.995	0.943
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.033203	0.11499	-0.40372	0.906	0.775
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.028349	0.072149	0.20410	0.878	0.697
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	6.7248	8.1636	0.77140	0.879	0.417
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.3599	6.7084	0.57773	0.694	0.351
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-1.0991	6.8632	-0.21246	0.949	0.874
startle / PPI	average startle response to full pulse (120 dB)	-8.5457	39.479	0.00070057	0.937	0.830
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-23.992	40.058	-0.30375	0.753	0.554
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-20.167	36.107	-0.24699	0.745	0.581
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.53396	22.320	0.16965	0.995	0.981
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.99427	2.1971	-0.67493	0.934	0.656
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.28803	2.5975	-0.19529	0.987	0.913
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.10224	1.9341	-0.12008	0.990	0.958
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.059830	0.095861	0.59772	0.921	0.538
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.064673	0.072242	0.45186	0.694	0.378
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.040282	0.075631	-0.50106	0.802	0.599
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-8.5996	39.221	0.00070057	0.935	0.828
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-23.908	39.978	-0.29788	0.749	0.555
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-17.138	36.245	-0.17961	0.782	0.640
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	5.5709	22.811	0.34065	0.900	0.809
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.030439	0.17272	-0.23833	0.975	0.861
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.025366	0.091678	0.088436	0.910	0.784
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.094535	0.10291	-0.87116	0.628	0.366
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-62.101	146.05	-0.16965	0.849	0.674
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-94.433	144.38	-0.34957	0.722	0.518
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-60.710	138.41	-0.14553	0.801	0.664
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	24.310	86.796	0.34510	0.878	0.781
startle / PPI	maximum baseline movement during background noise	2.7306	4.1201	0.82931	0.855	0.513
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	1.8742	12.255	0.24121	0.997	0.880
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	4.1790	7.9023	0.28765	0.833	0.601
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.8533	8.2395	-0.66441	0.747	0.483
startle / PPI	maximum startle response to full pulse (120 dB)	-60.085	146.41	-0.14836	0.854	0.685
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-96.498	144.65	-0.36900	0.716	0.510
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-68.976	138.04	-0.20673	0.775	0.621
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	10.872	85.648	0.26581	0.944	0.900
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-4.8621	5.6541	-1.2973	0.796	0.400
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.23779	5.2503	-0.058180	0.996	0.964
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	1.2129	4.8064	0.060987	0.933	0.803

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	37.0 %	0.000112
eye morphology	anterior chamber depth	males	37.0 %	0.0000107
eye morphology	anterior chamber depth	both	37.0 %	8.92e-9
eye morphology	bulging eye	females	37.0 %	0.0000517
eye morphology	bulging eye	males	37.0 %	0.00000795
eye morphology	bulging eye	both	37.0 %	2.56e-9
eye morphology	cornea	females	46.0 %	0.0000266
eye morphology	cornea	males	37.0 %	0.0000490
eye morphology	cornea	both	41.0 %	4.21e-9
eye morphology	cornea opacity	females	37.0 %	0.000438
eye morphology	cornea opacity	males	37.0 %	0.0000395
eye morphology	cornea opacity	both	37.0 %	7.00e-8
eye morphology	cornea vascularization	females	37.0 %	0.000268
eye morphology	cornea vascularization	males	37.0 %	0.0000264
eye morphology	cornea vascularization	both	37.0 %	3.67e-8
eye morphology	corneal deposits	females	37.0 %	0.000296
eye morphology	corneal deposits	males	37.0 %	0.0000432
eye morphology	corneal deposits	both	37.0 %	3.07e-8
eye morphology	corneal mineralization	females	37.0 %	0.000259
eye morphology	corneal mineralization	males	49.0 %	3.22e-7
eye morphology	corneal mineralization	both	42.0 %	1.87e-9
eye morphology	corneal scleralization	females	37.0 %	0.000360
eye morphology	corneal scleralization	males	37.0 %	0.0000460
eye morphology	corneal scleralization	both	37.0 %	5.57e-8
eye morphology	corneal ulcer	females	37.0 %	0.000216
eye morphology	corneal ulcer	males	37.0 %	0.0000169
eye morphology	corneal ulcer	both	37.0 %	2.93e-8
eye morphology	eye closure	females	37.0 %	0.0000512
eye morphology	eye closure	males	37.0 %	0.00000787
eye morphology	eye closure	both	37.0 %	3.15e-9
eye morphology	eye hemorrhage or blood presence	females	37.0 %	0.000205
eye morphology	eye hemorrhage or blood presence	males	37.0 %	0.0000196
eye morphology	eye hemorrhage or blood presence	both	37.0 %	2.53e-8
eye morphology	eyelid morphology	females	37.0 %	0.0000890
eye morphology	eyelid morphology	males	37.0 %	0.00000787
eye morphology	eyelid morphology	both	37.0 %	5.99e-9
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	61.0 %	0.00000272
eye morphology	fusion between cornea and lens	males	73.0 %	3.15e-9
eye morphology	fusion between cornea and lens	both	67.0 %	2.29e-14
eye morphology	iris pigmentation	females	37.0 %	0.000264
eye morphology	iris pigmentation	males	37.0 %	0.0000420
eye morphology	iris pigmentation	both	37.0 %	4.68e-8
eye morphology	iris transillumination	females	37.0 %	0.000101
eye morphology	iris transillumination	males	37.0 %	0.0000228
eye morphology	iris transillumination	both	37.0 %	7.48e-9
eye morphology	irispupil	females	37.0 %	0.000463
eye morphology	irispupil	males	47.0 %	0.00000686
eye morphology	irispupil	both	40.0 %	1.56e-8
eye morphology	lacrimation	females	36.0 %	0.000802
eye morphology	lacrimation	males	37.0 %	0.000370
eye morphology	lacrimation	both	37.0 %	6.01e-7
eye morphology	lens	females	36.0 %	0.00372
eye morphology	lens	males	37.0 %	0.00128
eye morphology	lens	both	36.0 %	0.00000632
eye morphology	lens opacity	females	61.0 %	0.0000139
eye morphology	lens opacity	males	73.0 %	5.11e-8
eye morphology	lens opacity	both	67.0 %	4.33e-13
eye morphology	narrow eye opening	females	37.0 %	0.000230
eye morphology	narrow eye opening	males	37.0 %	0.0000167
eye morphology	narrow eye opening	both	37.0 %	2.81e-8
eye morphology	optic disc	females	61.0 %	0.00000532
eye morphology	optic disc	males	73.0 %	2.81e-8
eye morphology	optic disc	both	67.0 %	1.80e-13
eye morphology	persistence of hyaloid vascular system	females	61.0 %	0.0000318
eye morphology	persistence of hyaloid vascular system	males	73.0 %	7.15e-8
eye morphology	persistence of hyaloid vascular system	both	67.0 %	2.21e-12
eye morphology	pupil dilation	females	37.0 %	0.000206
eye morphology	pupil dilation	males	37.0 %	0.0000747
eye morphology	pupil dilation	both	37.0 %	4.44e-8
eye morphology	pupil light response	females	37.0 %	0.000261
eye morphology	pupil light response	males	37.0 %	0.0000557
eye morphology	pupil light response	both	37.0 %	3.58e-8
eye morphology	pupil position	females	37.0 %	0.000654
eye morphology	pupil position	males	47.0 %	0.00000745
eye morphology	pupil position	both	40.0 %	2.50e-8
eye morphology	pupil shape	females	37.0 %	0.000438
eye morphology	pupil shape	males	37.0 %	0.0000595
eye morphology	pupil shape	both	37.0 %	7.79e-8
eye morphology	retina	females	61.0 %	0.0000226
eye morphology	retina	males	73.0 %	8.38e-8
eye morphology	retina	both	67.0 %	1.08e-12
eye morphology	retinal blood vessels	females	61.0 %	0.00000174
eye morphology	retinal blood vessels	males	73.0 %	7.49e-9
eye morphology	retinal blood vessels	both	67.0 %	3.57e-14
eye morphology	retinal blood vessels pattern	females	61.0 %	0.00000727
eye morphology	retinal blood vessels pattern	males	73.0 %	2.20e-8
eye morphology	retinal blood vessels pattern	both	67.0 %	2.22e-13
eye morphology	retinal blood vessels structure	females	61.0 %	0.00000481
eye morphology	retinal blood vessels structure	males	73.0 %	1.47e-8
eye morphology	retinal blood vessels structure	both	67.0 %	1.12e-13
eye morphology	retinal pigmentation	females	61.0 %	0.0000228
eye morphology	retinal pigmentation	males	73.0 %	7.90e-8
eye morphology	retinal pigmentation	both	67.0 %	1.10e-12
eye morphology	retinal structure	females	61.0 %	0.00000522
eye morphology	retinal structure	males	73.0 %	2.69e-8
eye morphology	retinal structure	both	67.0 %	1.59e-13
eye morphology	synechia	females	59.0 %	2.27e-7
eye morphology	synechia	males	73.0 %	7.76e-11
eye morphology	synechia	both	66.0 %	6.09e-17
eye morphology	vitreous	females	61.0 %	0.00000199
eye morphology	vitreous	males	73.0 %	3.82e-9
eye morphology	vitreous	both	67.0 %	2.31e-14
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	12.0 %	0.0404
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	6.0 %	0.0878
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	32.0 %	0.00854
SHIRPA	limb grasp	both	18.0 %	0.0254
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	12.0 %	0.0876
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	6.0 %	0.109
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Itfg2^em1(IMPC)J/Mmjax -/+ with genotype: