MPD: JaxKOMP-EAP genotype: Rgsl1<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Rgsl1^em1(IMPC)J/Mmjax -/- Gene Rgsl1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.75000	2.8657	-0.49487	0.945	0.798
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-6.0821	4.0155	-1.1758	0.647	0.158
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.25000	2.5158	-0.12030	0.975	0.922
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.0000	4.1251	-0.27141	0.931	0.813
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-0.25000	4.3965	-0.068748	0.984	0.956
body composition	body length	0.032364	0.044531	0.66119	0.742	0.472
body composition	body weight (at time of DXA)	-2.3433	0.86631	-1.3762	0.0564	0.00999
body composition	bone area, whole body scan, head excluded	-0.30465	0.16753	-0.98059	0.279	0.0765
body composition	bone mineral content of whole body scan, head excluded	-0.0078430	0.011866	-0.31075	0.751	0.513
body composition	bone mineral content to body weight ratio	-0.00031621	0.00047870	-0.24124	0.745	0.513
body composition	bone mineral density of whole body scan, head excluded	0.00017180	0.00051989	0.22103	0.878	0.743
body composition	fat tissue mass of whole body scan, head excluded	0.29949	0.50537	0.49301	0.768	0.557
body composition	fat tissue mass to body weight ratio	0.0066090	0.015907	0.37007	0.841	0.680
body composition	lean tissue mass of whole body scan, head excluded	-0.26847	0.34325	-0.73041	0.726	0.439
body composition	lean tissue mass to body weight ratio	-0.010235	0.012650	-0.61191	0.661	0.423
body composition	percent fat, whole body scan, head excluded	0.72268	1.5224	0.43223	0.813	0.638
body composition	ratio of soft-tissue attenuation coefficients	-0.00072688	0.0016897	-0.38120	0.834	0.669
body composition	tissue area	0.056394	0.24726	0.38665	0.945	0.821
body composition	total tissue mass, whole body scan, head excluded	0.065612	0.26614	-0.080638	0.906	0.807
clinical blood chemistry	alanine transaminase (plasma ALT)	-4.5958	3.2931	-0.44894	0.549	0.179
clinical blood chemistry	albumin (plasma Alb)	-0.11498	0.60506	-0.11432	0.949	0.851
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.2764	4.2952	0.048905	0.688	0.455
clinical blood chemistry	aspartate transaminase (plasma AST)	-13.422	12.977	-0.65504	0.633	0.314
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.17880	0.24178	-0.57191	0.810	0.469
clinical blood chemistry	blood urea nitrogen (BUN)	-0.24286	1.4580	-0.13296	0.939	0.869
clinical blood chemistry	calcium (plasma Ca)	-0.25433	0.069068	-1.4485	0.0217	0.00158
clinical blood chemistry	creatinine (plasma)	-0.056617	0.028532	-1.1168	0.229	0.0627
clinical blood chemistry	glucose (plasma GLU, no fast)	-3.6616	8.5294	0.15270	0.815	0.673
clinical blood chemistry	HDL cholesterol (plasma HDL)	2.2946	3.5006	0.21780	0.774	0.520
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0014368	0.0086990	-0.066237	0.969	0.871
clinical blood chemistry	phosphorus (plasma phosphate)	-1.0734	0.43635	-1.5670	0.150	0.0236
clinical blood chemistry	total bilirubin (plasma TBIL)	0.012575	0.0089436	0.79053	0.506	0.176
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.3915	4.4987	0.53898	0.649	0.342
clinical blood chemistry	total protein (plasma TP)	-0.36480	0.94628	-0.35414	0.860	0.704
clinical blood chemistry	triglyceride (plasma TG, no fast)	-6.0090	10.557	-0.11471	0.793	0.576
EKG	duration of PQ interval	0.33958	1.0013	0.50645	0.939	0.737
EKG	duration of PR interval	0.53611	0.93895	0.62717	0.926	0.573
EKG	duration of QRS interval	0.61848	0.33459	1.5196	0.885	0.0751
EKG	duration of QT interval	0.91098	0.71345	1.0214	0.703	0.213
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.89372	0.84356	0.99459	0.835	0.299
EKG	duration of RR interval	0.55645	1.4275	0.53879	0.890	0.700
EKG	duration of ST interval	0.49808	0.73236	0.74182	0.868	0.502
EKG	heart rate coefficient of variation (signal intensity)	0.33399	1.1395	0.35812	0.968	0.772
EKG	heart rate variability, mean of differences between sequential beats; beats per min	1.6027	8.2503	0.25668	0.972	0.847
EKG	heart rate, beats per min	-4.1170	12.131	-0.50346	0.898	0.737
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.057639	0.11294	-0.58533	0.872	0.614
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.20430	0.14964	-1.2383	0.548	0.183
EKG	number of signals	4.4724	6.8375	0.84680	0.883	0.518
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	4.1215	5.4566	0.84569	0.858	0.456
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-0.020833	3.3305	0.030229	0.999	0.995
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.36528	3.6575	-0.090798	0.986	0.921
EKG	root mean square of successive differences of neighboring RR intervals	-0.33778	1.8637	-0.072603	0.965	0.857
glucose tolerance test	amount glucose injected	-0.27283	5.1037	0.31376	0.982	0.959
glucose tolerance test	plasma glucose, 0min	7.1472	10.210	0.51623	0.720	0.515
glucose tolerance test	plasma glucose, 15min	42.583	19.240	1.2618	0.331	0.0778
glucose tolerance test	plasma glucose, 30min	22.008	16.911	0.79030	0.583	0.250
glucose tolerance test	plasma glucose, 60min	-4.6958	12.624	-0.068691	0.900	0.725
glucose tolerance test	plasma glucose, 120min	7.0687	13.506	0.33275	0.841	0.623
grip strength	body weight (at time of grip strength test)	-1.2465	0.49280	-0.88071	0.0626	0.0150
grip strength	forelimb and hindlimb grip strength (mean of trials), average	12.071	6.2531	1.1274	0.182	0.0600
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.52248	0.26572	0.95284	0.180	0.0555
grip strength	forelimb and hindlimb grip strength by trial, trial1	22.578	10.578	1.6465	0.198	0.0384
grip strength	forelimb and hindlimb grip strength by trial, trial2	17.416	9.5642	1.2902	0.257	0.0754
grip strength	forelimb and hindlimb grip strength by trial, trial3	-4.9967	8.3004	-0.13401	0.769	0.550
grip strength	forelimb grip strength (mean of trials), average	0.51128	4.3890	0.35592	0.968	0.908
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.16478	0.21426	0.67540	0.707	0.446
grip strength	forelimb grip strength by trial, trial1	-1.6431	5.8897	0.088705	0.918	0.782
grip strength	forelimb grip strength by trial, trial2	2.9537	5.1547	0.56619	0.830	0.569
grip strength	forelimb grip strength by trial, trial3	-0.033826	5.7186	0.25395	0.997	0.995
heart weight	heart weight, normalized to body weight	-0.18425	0.11301	-1.1766	0.289	0.117
heart weight	heart weight, weight	-5.8972	3.3785	-1.1875	0.260	0.0942
hematology	basophil differential (percent of total WBC)	-0.040667	0.024296	-0.60788	0.530	0.111
hematology	calculated hemoglobin (cHGB)	0.30381	0.18889	0.66904	0.379	0.125
hematology	eosinophil differential (percent of total WBC)	-0.54176	0.29589	-1.3680	0.425	0.0828
hematology	hematocrit (HCT)	1.0677	0.53718	0.86881	0.293	0.0615
hematology	hemoglobin concentration distribution width (HDW)	-0.070720	0.025967	-1.7402	0.136	0.0135
hematology	large unstained cells (percent of total WBC)	0.18832	0.075268	1.2073	0.216	0.0222
hematology	lymphocyte differential (percent of total WBC)	3.7959	3.9602	1.2287	0.597	0.350
hematology	mean corpuscular hemoglobin (CHr)	-0.0025804	0.064948	0.0076043	0.984	0.969
hematology	mean platelet volume (MPV)	-0.20138	0.068071	-1.2178	0.0469	0.00807
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.064176	0.11368	-0.27065	0.820	0.579
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.46410	0.28291	-0.84945	0.443	0.117
hematology	mean RBC corpuscular volume (MCV)	0.27014	0.27653	0.50443	0.573	0.341
hematology	measured hemoglobin (mHGB)	0.20208	0.20390	0.29195	0.629	0.334
hematology	monocyte differential (percent of total WBC)	-0.22954	0.28058	-0.56114	0.732	0.423
hematology	neutrophil differential (percent of total WBC)	-2.9973	3.7588	-1.1644	0.650	0.435
hematology	platelet count (PLT; units per volume x 10³)	55.218	63.703	0.77677	0.725	0.397
hematology	RBC corpuscular distribution width (RDW)	-0.18934	0.26060	-0.69572	0.706	0.476
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.16434	0.18747	-0.49074	0.654	0.392
hematology	red blood cell count (RBC; per volume x 10⁶)	0.14295	0.15575	0.30858	0.641	0.370
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-11.464	17.985	-0.41172	0.829	0.531
hematology	reticulocyte differential (percent of total RBC)	-0.16418	0.18418	-0.50816	0.721	0.384
hematology	white blood cell count (WBC; units per volume x 10³)	1.3206	0.66193	1.0628	0.186	0.0614
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.8026	0.67149	1.5725	0.301	0.0101
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.44619	0.40879	0.83922	0.775	0.281
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.63022	0.70220	1.0300	0.825	0.374
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.59857	0.96045	0.66025	0.859	0.536
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.14315	0.42489	0.34696	0.951	0.738
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.42172	0.27770	1.0896	0.751	0.136
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.0093077	0.28718	-0.053268	1.00	0.974
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.74617	0.45925	1.3149	0.647	0.111
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.88513	0.46173	1.4410	0.477	0.0616
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.15678	0.29147	0.46627	0.935	0.593
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.095512	0.29265	-0.22311	0.950	0.746
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.097489	0.52344	-0.052316	0.965	0.853
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.25316	0.86286	0.33510	0.937	0.771
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.59425	0.57150	0.95316	0.721	0.304
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.21952	0.58379	0.40008	0.911	0.709
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.6327	0.80700	1.4136	0.408	0.0490
holeboard	total number of hole pokes, 20 min test	8.5851	4.3660	1.1828	0.261	0.0554
light / dark	fecal boli count, 20 min test	-0.41843	0.73651	-0.43741	0.857	0.572
light / dark	latency to enter dark zone, 20 min test	-16.801	38.533	-0.42037	0.899	0.665
light / dark	number of transitions between light and dark zones, 20 min test	1.7027	6.1880	0.26958	0.906	0.784
light / dark	percentage of total time in dark zone, 20 min test	0.73141	2.2212	0.27378	0.914	0.743
light / dark	percentage of total time in light zone, 20 min test	-0.73141	2.2212	-0.27940	0.916	0.743
light / dark	time mobile in dark zone, 20 min test	17.315	9.9499	0.86065	0.325	0.0880
light / dark	time mobile in light zone, 20 min test	15.492	9.0021	0.65677	0.294	0.0916
light / dark	time spent in dark zone, 20 min test	46.961	36.331	0.92927	0.633	0.202
light / dark	time spent in light zone, 20 min test	-46.961	36.331	-0.92927	0.633	0.202
open field	average speed in center of arena, 20 min test	0.33862	0.31737	0.53073	0.636	0.291
open field	average speed in periphery of arena, 20 min test	0.32318	0.13645	0.69785	0.0954	0.0218
open field	distance traveled habituation ratio, 20 min test	-7.1505	6.8455	-0.59203	0.621	0.301
open field	distance traveled in center of arena, 20 min test	189.53	73.000	0.82151	0.0843	0.0123
open field	distance traveled in periphery of arena, 20 min test	244.16	137.23	0.50463	0.251	0.0813
open field	distance traveled slope, 20 min test	-7.9005	6.5782	-0.69614	0.569	0.236
open field	distance traveled, 20 min test, 1st 5min	144.00	61.464	0.76992	0.116	0.0232
open field	distance traveled, 20 min test, 2nd 5min	125.70	56.272	0.87934	0.142	0.0300
open field	distance traveled, 20 min test, 3rd 5min	90.361	43.340	0.55719	0.171	0.0422
open field	distance traveled, 20 min test, 4th 5min	78.090	50.231	0.39757	0.328	0.126
open field	number of clockwise revolution episodes, 20 min test	2.3439	1.2860	0.88889	0.349	0.0745
open field	number of counter-clockwise revolution episodes, 20 min test	1.1910	1.1750	0.21169	0.600	0.316
open field	number of fecal boli, 20 min test	-0.16533	1.0803	0.15188	0.951	0.879
open field	number of rears in 5 min bins, 20 min test, 1st 5min	4.0334	1.6388	0.88690	0.123	0.0173
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	5.4651	2.3302	1.0481	0.143	0.0230
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-15.139	27.809	-2.6738	0.787	0.589
open field	number of rears in 5 min bins, 20 min test, 4th 5min	4.8250	2.4272	0.74134	0.245	0.0523
open field	percentage of total time in center of arena, 20 min test	3.9146	1.9382	0.70300	0.278	0.0489
open field	percentage of total time in center of arena, slope, 20 min test	-0.52453	0.79175	-0.18294	0.863	0.511
open field	percentage of total time in center, habituation ratio, 20 min test	-1.0125	0.74829	-0.42680	0.662	0.182
open field	percentage of total time in corners of arena, 20 min test	-6.0498	3.5221	-0.83856	0.374	0.0922
open field	percentage of total time in corners, habituation ratio, 20 min test	2.0419	1.5507	0.65398	0.690	0.194
open field	percentage of total time in corners, slope, 20 min test	1.5694	1.4575	0.44008	0.768	0.287
open field	permanence time in center of arena, 20 min test	44.609	23.319	0.66065	0.317	0.0615
open field	permanence time in corners of arena, 20 min test	-72.599	42.265	-0.83856	0.374	0.0922
open field	permanence time in periphery of arena, 20 min test	-44.606	23.321	-0.66065	0.317	0.0615
open field	total distance traveled, 20 min test	434.07	173.10	0.73429	0.0745	0.0154
open field	total number of rears, 20 min test	17.093	7.2135	0.83096	0.122	0.0218
open field	whole arena average speed, 20 min test	0.36184	0.14410	0.73957	0.0737	0.0153
open field	whole arena resting time, 20 min test	-34.558	16.609	-0.39757	0.146	0.0426
open field	whole arena time spent mobile, 20 min test	36.809	16.471	0.72203	0.115	0.0300
open field	whole arena time spent vertical, 20 min test	5.6244	7.0801	0.34150	0.722	0.431
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.13576	1.5686	0.26462	0.984	0.932
startle / PPI	average baseline movement during background noise	0.43779	1.5743	0.37952	0.963	0.782
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.074483	0.059519	0.58603	0.580	0.217
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.13514	0.12435	1.2223	0.629	0.283
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.4951	7.1489	0.54981	0.910	0.533
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.5775	6.6426	0.61117	0.680	0.327
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.6534	6.2633	0.50155	0.674	0.371
startle / PPI	average startle response to full pulse (120 dB)	-32.633	36.947	-0.43432	0.628	0.382
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-30.464	32.674	-0.42970	0.592	0.356
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-36.992	33.103	-0.55798	0.489	0.269
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-29.888	29.778	-0.53036	0.550	0.321
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.47867	1.0924	0.40981	0.935	0.663
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.64839	1.3381	0.45132	0.928	0.630
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.82677	2.4976	0.22969	0.936	0.742
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.16313	0.20371	1.6052	0.894	0.427
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.18378	0.15935	1.4973	0.600	0.255
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.085813	0.075268	0.48838	0.522	0.260
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-32.814	37.405	-0.43586	0.627	0.385
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-30.689	32.766	-0.41897	0.589	0.354
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-36.851	33.390	-0.54493	0.489	0.275
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-30.523	30.352	-0.51910	0.533	0.320
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.081207	0.082275	0.74340	0.860	0.329
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.077911	0.075877	0.53472	0.651	0.310
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.064658	0.076683	0.29586	0.656	0.403
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-93.702	134.40	-0.31551	0.718	0.489
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-81.659	110.87	-0.29057	0.679	0.465
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-105.18	120.51	-0.39462	0.602	0.387
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-76.254	106.53	-0.28765	0.671	0.478
startle / PPI	maximum baseline movement during background noise	-0.032316	2.9786	0.11867	0.998	0.991
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.6289	7.5046	0.59939	0.906	0.457
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.2192	7.2084	0.56290	0.675	0.322
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	4.9612	6.4879	0.32583	0.722	0.448
startle / PPI	maximum startle response to full pulse (120 dB)	-94.392	133.57	-0.31256	0.708	0.483
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-79.932	110.75	-0.27744	0.685	0.474
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-105.97	119.76	-0.40676	0.597	0.381
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-76.080	105.03	-0.30962	0.665	0.472
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	4.5871	2.8828	1.2054	0.603	0.118
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	1.7472	3.2626	0.52875	0.903	0.595
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	0.60913	6.4193	-0.042748	0.984	0.925

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	11.0 %	0.257
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	5.0 %	0.344
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	4.0 %	0.428
eye morphology	cornea vascularization	females	12.0 %	0.189
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	6.0 %	0.234
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	11.0 %	0.220
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	5.0 %	0.292
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	48.0 %	0.000118
eye morphology	fusion between cornea and lens	males	23.0 %	0.0145
eye morphology	fusion between cornea and lens	both	36.0 %	0.00000396
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	49.0 %	0.000163
eye morphology	lens	males	24.0 %	0.0275
eye morphology	lens	both	36.0 %	0.00000632
eye morphology	lens opacity	females	53.0 %	0.0000406
eye morphology	lens opacity	males	23.0 %	0.0306
eye morphology	lens opacity	both	36.0 %	0.00000570
eye morphology	narrow eye opening	females	12.0 %	0.171
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	6.0 %	0.144
eye morphology	optic disc	females	48.0 %	0.000186
eye morphology	optic disc	males	23.0 %	0.0190
eye morphology	optic disc	both	36.0 %	0.0000129
eye morphology	persistence of hyaloid vascular system	females	49.0 %	0.000313
eye morphology	persistence of hyaloid vascular system	males	23.0 %	0.0310
eye morphology	persistence of hyaloid vascular system	both	36.0 %	0.0000369
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	48.0 %	0.000604
eye morphology	retina	males	23.0 %	0.0485
eye morphology	retina	both	36.0 %	0.0000518
eye morphology	retinal blood vessels	females	48.0 %	0.0000634
eye morphology	retinal blood vessels	males	23.0 %	0.0156
eye morphology	retinal blood vessels	both	36.0 %	0.00000597
eye morphology	retinal blood vessels pattern	females	48.0 %	0.000223
eye morphology	retinal blood vessels pattern	males	23.0 %	0.0173
eye morphology	retinal blood vessels pattern	both	36.0 %	0.0000166
eye morphology	retinal blood vessels structure	females	48.0 %	0.000137
eye morphology	retinal blood vessels structure	males	23.0 %	0.0119
eye morphology	retinal blood vessels structure	both	36.0 %	0.0000105
eye morphology	retinal pigmentation	females	48.0 %	0.000665
eye morphology	retinal pigmentation	males	23.0 %	0.0491
eye morphology	retinal pigmentation	both	36.0 %	0.0000531
eye morphology	retinal structure	females	48.0 %	0.000154
eye morphology	retinal structure	males	23.0 %	0.0153
eye morphology	retinal structure	both	36.0 %	0.0000116
eye morphology	synechia	females	48.0 %	0.0000651
eye morphology	synechia	males	23.0 %	0.0149
eye morphology	synechia	both	36.0 %	0.00000320
eye morphology	vitreous	females	48.0 %	0.000108
eye morphology	vitreous	males	23.0 %	0.00964
eye morphology	vitreous	both	36.0 %	0.00000438
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.00
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.00
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.00
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.00
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.00
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.00
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.00
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.00
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.00
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.00
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.00
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.00
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.00
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.00
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	25.0 %	0.00296
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	10.0 %	0.00556
SHIRPA	genitalia presence	females	0.0 %	1.00
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.00
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.00
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.00
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.00
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.00
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.00
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	11.0 %	0.297
SHIRPA	limb grasp	both	3.0 %	0.530
SHIRPA	lower lip morphology	females	0.0 %	1.00
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.00
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.00
SHIRPA	snout size	males	16.0 %	0.0329
SHIRPA	snout size	both	10.0 %	0.0363
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.0
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.00
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.00
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.00
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.00
SHIRPA	tremor	males	0.0 %	1.00
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.00
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.0
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Rgsl1^em1(IMPC)J/Mmjax -/- with genotype: