MPD: JaxKOMP-EAP genotype: Dgkb<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Dgkb^em1(IMPC)J/Mmjax -/- Gene Dgkb

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-2.2492	2.2353	-0.88342	0.740	0.333
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.6621	5.5180	-0.57667	0.895	0.638
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-3.9513	2.8205	-0.99306	0.543	0.183
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-2.2987	2.7652	-0.48967	0.748	0.420
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-2.9449	3.1488	-0.48207	0.702	0.366
body composition	body length	0.063639	0.039741	1.0429	0.371	0.117
body composition	body weight (at time of DXA)	-0.64818	0.74466	-0.39261	0.610	0.389
body composition	bone area, whole body scan, head excluded	-0.36470	0.14379	-1.1464	0.102	0.0152
body composition	bone mineral content of whole body scan, head excluded	-0.026232	0.012162	-1.1979	0.184	0.0371
body composition	bone mineral content to body weight ratio	-0.0011780	0.00044566	-1.2322	0.0878	0.0118
body composition	bone mineral density of whole body scan, head excluded	-0.00078667	0.00071330	-0.82807	0.575	0.277
body composition	fat tissue mass of whole body scan, head excluded	1.1629	0.37952	1.5464	0.0489	0.00395
body composition	fat tissue mass to body weight ratio	0.032925	0.012284	1.3382	0.0748	0.0107
body composition	lean tissue mass of whole body scan, head excluded	-0.15403	0.33756	-0.49919	0.859	0.651
body composition	lean tissue mass to body weight ratio	-0.020424	0.010463	-1.1125	0.228	0.0581
body composition	percent fat, whole body scan, head excluded	3.0275	1.1680	1.3517	0.0885	0.0134
body composition	ratio of soft-tissue attenuation coefficients	-0.0032496	0.0013177	-1.3270	0.106	0.0182
body composition	tissue area	0.36895	0.21636	1.2583	0.342	0.0961
body composition	total tissue mass, whole body scan, head excluded	1.0217	0.26441	1.6875	0.00792	0.000410
clinical blood chemistry	alanine transaminase (plasma ALT)	49.527	28.798	1.9525	0.444	0.0983
clinical blood chemistry	albumin (plasma Alb)	0.29756	0.50419	0.44800	0.823	0.561
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.5716	2.2238	0.10006	0.332	0.122
clinical blood chemistry	aspartate transaminase (plasma AST)	28.867	24.734	1.0491	0.568	0.255
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.27477	0.41190	-0.86243	0.825	0.511
clinical blood chemistry	blood urea nitrogen (BUN)	1.7726	1.0755	0.68941	0.332	0.112
clinical blood chemistry	calcium (plasma Ca)	-0.091734	0.074393	-0.30241	0.456	0.230
clinical blood chemistry	creatinine (plasma)	0.041045	0.019032	1.1400	0.186	0.0422
clinical blood chemistry	glucose (plasma GLU, no fast)	-13.074	10.522	-0.22249	0.427	0.227
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.57175	3.0922	-0.19464	0.954	0.855
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.011468	0.011692	-0.77684	0.658	0.336
clinical blood chemistry	phosphorus (plasma phosphate)	0.22474	0.21528	0.32108	0.597	0.307
clinical blood chemistry	total bilirubin (plasma TBIL)	0.012067	0.0085568	0.75986	0.500	0.172
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.4766	3.7392	0.027729	0.893	0.697
clinical blood chemistry	total protein (plasma TP)	0.22947	0.72183	0.12020	0.890	0.753
clinical blood chemistry	triglyceride (plasma TG, no fast)	6.7349	8.8995	0.58889	0.715	0.457
EKG	duration of PQ interval	-1.9292	0.90850	-1.6868	0.507	0.0434
EKG	duration of PR interval	-1.4418	0.79352	-1.2563	0.621	0.0803
EKG	duration of QRS interval	0.28152	0.31255	0.65189	0.897	0.376
EKG	duration of QT interval	2.6446	1.4391	2.2068	0.574	0.0771
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.57756	1.1506	0.70775	0.938	0.620
EKG	duration of RR interval	5.3667	2.5161	2.3722	0.369	0.0425
EKG	duration of ST interval	2.3452	1.4123	2.2553	0.616	0.108
EKG	heart rate coefficient of variation (signal intensity)	2.6247	1.1092	1.9897	0.623	0.0254
EKG	heart rate variability, mean of differences between sequential beats; beats per min	14.365	6.8397	1.6310	0.711	0.0452
EKG	heart rate, beats per min	-40.617	18.414	-2.3095	0.319	0.0364
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.17269	0.058131	-1.4523	0.145	0.00632
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.28337	0.076810	-1.6383	0.0649	0.00105
EKG	number of signals	-5.1118	6.5774	-0.98800	0.858	0.444
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	16.970	6.2633	2.3686	0.662	0.0116
EKG	QT dispersion, measured as inter-lead variability of QT intervals	7.4449	3.7634	1.8071	0.858	0.0582
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	8.6841	4.2742	1.7673	0.748	0.0525
EKG	root mean square of successive differences of neighboring RR intervals	1.5813	1.5548	0.91206	0.850	0.318
glucose tolerance test	amount glucose injected	-1.2183	3.7114	-0.00068750	0.918	0.748
glucose tolerance test	plasma glucose, 0min	-0.97647	6.9287	-0.33420	0.951	0.890
glucose tolerance test	plasma glucose, 15min	48.106	27.855	1.3944	0.381	0.106
glucose tolerance test	plasma glucose, 30min	51.082	21.351	1.5620	0.201	0.0313
glucose tolerance test	plasma glucose, 60min	13.976	12.707	0.67191	0.617	0.290
glucose tolerance test	plasma glucose, 120min	20.259	10.381	1.1919	0.334	0.0713
grip strength	body weight (at time of grip strength test)	0.77061	0.77467	0.91987	0.532	0.338
grip strength	forelimb and hindlimb grip strength (mean of trials), average	34.639	10.233	2.4597	0.0362	0.00542
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	1.3818	0.65360	1.9817	0.180	0.0561
grip strength	forelimb and hindlimb grip strength by trial, trial1	28.688	18.250	1.9419	0.391	0.140
grip strength	forelimb and hindlimb grip strength by trial, trial2	48.521	13.740	2.9221	0.0443	0.00369
grip strength	forelimb and hindlimb grip strength by trial, trial3	28.232	13.269	1.9232	0.234	0.0548
grip strength	forelimb grip strength (mean of trials), average	24.149	7.0097	2.8314	0.0461	0.00435
grip strength	forelimb grip strength (mean of trials), average normalized to bw	1.0306	0.38927	2.3785	0.120	0.0201
grip strength	forelimb grip strength by trial, trial1	20.469	8.7117	2.3106	0.248	0.0353
grip strength	forelimb grip strength by trial, trial2	24.527	11.402	2.6991	0.276	0.0509
grip strength	forelimb grip strength by trial, trial3	27.731	9.8970	2.8314	0.144	0.0150
heart weight	heart weight, normalized to body weight	0.032473	0.11761	-0.33093	0.883	0.785
heart weight	heart weight, weight	-0.80988	3.2620	-0.46860	0.897	0.806
hematology	basophil differential (percent of total WBC)	-0.020492	0.032603	-0.30675	0.842	0.536
hematology	calculated hemoglobin (cHGB)	0.031095	0.16229	-0.18532	0.941	0.850
hematology	eosinophil differential (percent of total WBC)	0.13731	0.17234	0.49003	0.789	0.433
hematology	hematocrit (HCT)	0.46059	0.49025	0.13986	0.630	0.357
hematology	hemoglobin concentration distribution width (HDW)	-0.092351	0.019898	-2.1286	0.00529	0.000114
hematology	large unstained cells (percent of total WBC)	-0.023930	0.047781	-0.14030	0.846	0.621
hematology	lymphocyte differential (percent of total WBC)	3.1614	1.8938	1.0508	0.335	0.108
hematology	mean corpuscular hemoglobin (CHr)	-0.024884	0.081150	-0.17861	0.888	0.762
hematology	mean platelet volume (MPV)	0.075302	0.057898	0.31738	0.419	0.206
hematology	mean RBC corpuscular hemoglobin (MCH)	0.073534	0.091093	0.25263	0.758	0.427
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.16924	0.18409	0.39789	0.715	0.367
hematology	mean RBC corpuscular volume (MCV)	0.098010	0.29526	0.21905	0.881	0.743
hematology	measured hemoglobin (mHGB)	0.21816	0.16241	0.32494	0.501	0.192
hematology	monocyte differential (percent of total WBC)	-0.18209	0.13247	-0.40586	0.545	0.182
hematology	neutrophil differential (percent of total WBC)	-3.0338	1.8063	-1.1752	0.316	0.107
hematology	platelet count (PLT; units per volume x 10³)	23.362	46.323	0.35444	0.847	0.619
hematology	RBC corpuscular distribution width (RDW)	-0.43756	0.15865	-1.5093	0.0995	0.0109
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.20257	0.17667	-0.58325	0.523	0.263
hematology	red blood cell count (RBC; per volume x 10⁶)	0.078614	0.13426	0.0027365	0.769	0.564
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-45.937	16.082	-1.6462	0.168	0.00893
hematology	reticulocyte differential (percent of total RBC)	-0.49304	0.16206	-1.6610	0.164	0.00578
hematology	white blood cell count (WBC; units per volume x 10³)	0.16562	0.67165	0.31253	0.895	0.807
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.023984	0.70536	0.022790	0.992	0.973
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.39630	0.66269	0.76019	0.887	0.553
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.052033	0.42853	0.16704	0.968	0.904
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.77962	0.57613	0.82728	0.653	0.183
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.60734	0.42404	0.99612	0.663	0.159
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.66115	0.32773	1.4136	0.563	0.0496
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.42080	0.29807	1.0642	0.738	0.165
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.69226	0.40100	1.2350	0.599	0.0911
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.57628	0.36724	1.0706	0.573	0.124
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.33016	0.40325	0.89438	0.870	0.417
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.40988	0.34015	0.97102	0.804	0.234
holeboard	number of hole pokes by individual hole number, 20 min test, 12	1.6244	0.45398	2.0783	0.0905	0.000842
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.2014	0.77962	1.1727	0.524	0.130
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.22729	0.41940	0.45180	0.868	0.591
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.90303	0.52039	1.3779	0.561	0.0895
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.9723	0.69549	1.6339	0.230	0.00683
holeboard	total number of hole pokes, 20 min test	10.211	3.8162	1.3397	0.110	0.0104
light / dark	fecal boli count, 20 min test	0.19941	0.47537	0.23329	0.900	0.677
light / dark	latency to enter dark zone, 20 min test	-26.927	30.305	-0.60075	0.763	0.379
light / dark	number of transitions between light and dark zones, 20 min test	11.159	10.819	1.1239	0.628	0.308
light / dark	percentage of total time in dark zone, 20 min test	0.63068	3.8292	0.24582	0.963	0.870
light / dark	percentage of total time in light zone, 20 min test	-0.63068	3.8292	-0.25139	0.963	0.870
light / dark	time mobile in dark zone, 20 min test	18.168	11.825	0.89848	0.411	0.132
light / dark	time mobile in light zone, 20 min test	11.322	13.118	0.45759	0.652	0.393
light / dark	time spent in dark zone, 20 min test	26.184	44.470	0.59913	0.855	0.559
light / dark	time spent in light zone, 20 min test	-26.184	44.470	-0.59913	0.855	0.559
open field	average speed in center of arena, 20 min test	1.0335	0.39204	1.5967	0.138	0.0119
open field	average speed in periphery of arena, 20 min test	0.53204	0.16650	1.3343	0.0242	0.00272
open field	distance traveled habituation ratio, 20 min test	-4.9622	8.4966	-0.38742	0.800	0.563
open field	distance traveled in center of arena, 20 min test	181.78	105.50	0.77898	0.285	0.0926
open field	distance traveled in periphery of arena, 20 min test	565.59	155.65	1.5504	0.0117	0.000787
open field	distance traveled slope, 20 min test	-3.5164	7.9420	-0.25030	0.865	0.660
open field	distance traveled, 20 min test, 1st 5min	251.38	75.953	1.4826	0.0229	0.00198
open field	distance traveled, 20 min test, 2nd 5min	143.35	57.693	1.0645	0.0957	0.0173
open field	distance traveled, 20 min test, 3rd 5min	161.01	58.809	1.2219	0.0636	0.00927
open field	distance traveled, 20 min test, 4th 5min	201.40	67.132	1.5030	0.0411	0.00469
open field	number of clockwise revolution episodes, 20 min test	4.5520	1.6265	1.6840	0.0971	0.00786
open field	number of counter-clockwise revolution episodes, 20 min test	3.2257	1.1784	1.2391	0.101	0.00920
open field	number of fecal boli, 20 min test	-1.5784	0.83191	-1.0119	0.301	0.0652
open field	number of rears in 5 min bins, 20 min test, 1st 5min	8.5770	2.4401	1.8886	0.0243	0.00111
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	6.0168	2.3524	1.1671	0.109	0.0144
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	6.8795	3.0671	1.2391	0.167	0.0305
open field	number of rears in 5 min bins, 20 min test, 4th 5min	7.6786	2.8796	1.3213	0.108	0.0111
open field	percentage of total time in center of arena, 20 min test	0.50048	2.6183	-0.073237	0.952	0.849
open field	percentage of total time in center of arena, slope, 20 min test	0.75437	1.2235	0.54625	0.868	0.541
open field	percentage of total time in center, habituation ratio, 20 min test	1.1083	1.2273	0.72029	0.816	0.372
open field	percentage of total time in corners of arena, 20 min test	-3.4411	4.4653	-0.30472	0.724	0.445
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.71696	1.7802	-0.63252	0.942	0.689
open field	percentage of total time in corners, slope, 20 min test	-0.64368	1.7773	-0.57769	0.940	0.719
open field	permanence time in center of arena, 20 min test	6.0094	31.423	-0.071891	0.952	0.849
open field	permanence time in corners of arena, 20 min test	-41.300	53.586	-0.30472	0.723	0.445
open field	permanence time in periphery of arena, 20 min test	-6.0401	31.427	0.070545	0.951	0.849
open field	total distance traveled, 20 min test	738.27	215.74	1.4210	0.0153	0.00145
open field	total number of rears, 20 min test	28.205	9.0462	1.4627	0.0377	0.00342
open field	whole arena average speed, 20 min test	0.61450	0.17990	1.4210	0.0155	0.00147
open field	whole arena resting time, 20 min test	-58.353	20.641	-0.99164	0.0437	0.00737
open field	whole arena time spent mobile, 20 min test	58.458	20.638	1.1995	0.0451	0.00727
open field	whole arena time spent vertical, 20 min test	26.919	9.3072	1.7805	0.0751	0.00616
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	3.8633	1.6786	1.7114	0.196	0.0287
startle / PPI	average baseline movement during background noise	1.0721	1.1599	0.74710	0.830	0.365
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.054268	0.071402	0.39917	0.763	0.454
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.068680	0.066806	0.60857	0.663	0.314
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	11.289	8.1651	1.3071	0.846	0.179
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.1243	7.4267	0.54981	0.734	0.417
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.5987	7.9139	0.28035	0.866	0.653
startle / PPI	average startle response to full pulse (120 dB)	-23.538	50.944	-0.28035	0.841	0.648
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-59.006	54.988	-0.87360	0.530	0.293
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-56.076	50.885	-0.87155	0.500	0.281
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-24.208	42.535	-0.39765	0.740	0.574
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.22835	2.1562	0.23833	0.985	0.917
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.1834	1.6388	-0.81555	0.880	0.477
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.2724	3.0296	-0.86338	0.913	0.678
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.11401	0.088184	1.1044	0.850	0.208
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.065079	0.078046	0.45652	0.711	0.412
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.031606	0.087589	0.088436	0.881	0.721
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-23.864	51.140	-0.28619	0.837	0.645
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-58.489	55.234	-0.86542	0.537	0.300
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-56.070	51.023	-0.86950	0.498	0.283
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-21.382	43.178	-0.31404	0.776	0.625
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.11449	0.092833	1.0089	0.826	0.229
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.017951	0.079944	0.035055	0.927	0.824
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.015633	0.095576	-0.063128	0.954	0.871
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-104.58	196.30	-0.36900	0.806	0.599
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-253.39	205.78	-1.0373	0.467	0.230
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-196.37	189.94	-0.83128	0.532	0.311
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-77.393	167.66	-0.30082	0.786	0.648
startle / PPI	maximum baseline movement during background noise	-0.21370	3.2721	0.066603	0.985	0.948
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	11.757	8.8218	1.2259	0.884	0.195
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	1.9591	7.6926	0.098941	0.925	0.801
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	2.2770	8.9905	0.070816	0.915	0.802
startle / PPI	maximum startle response to full pulse (120 dB)	-103.32	196.14	-0.36151	0.808	0.603
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-256.78	205.51	-1.0640	0.463	0.223
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-198.01	188.88	-0.84122	0.524	0.305
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-86.808	166.20	-0.36900	0.758	0.606
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.9962	4.5456	-0.54493	0.925	0.664
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-4.4705	4.1638	-1.1939	0.765	0.293
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-5.4671	7.3913	-1.3137	0.804	0.467

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	11.0 %	0.257
eye morphology	cornea	males	12.0 %	0.0788
eye morphology	cornea	both	12.0 %	0.0444
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	12.0 %	0.0696
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	6.0 %	0.0885
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	16.0 %	0.155
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	5.0 %	0.287
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	28.0 %	0.0386
eye morphology	retina	males	22.0 %	0.155
eye morphology	retina	both	25.0 %	0.0203
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	25.0 %	0.00657
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	12.0 %	0.00909
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	13.0 %	0.273
eye morphology	retinal pigmentation	males	10.0 %	0.432
eye morphology	retinal pigmentation	both	10.0 %	0.279
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.0
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.0
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.0
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.618
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.0
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.0
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Dgkb^em1(IMPC)J/Mmjax -/- with genotype: