MPD: JaxKOMP-EAP genotype: Spata31d1d<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Spata31d1d^em1(IMPC)J/Mmjax -/- Gene Spata31d1d

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.4258	1.0382	0.16643	0.668	0.242
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-3.9818	3.2266	-0.83920	0.730	0.285
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-3.9670	4.5503	-1.0001	0.761	0.433
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	2.3148	3.1873	0.26120	0.803	0.508
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	4.7224	2.6259	0.72281	0.526	0.147
body composition	body length	-0.050829	0.036382	-0.38791	0.454	0.168
body composition	body weight (at time of DXA)	0.029868	0.70151	0.13068	0.986	0.966
body composition	bone area, whole body scan, head excluded	-0.31400	0.11810	-1.0052	0.0804	0.0103
body composition	bone mineral content of whole body scan, head excluded	-0.025576	0.0099507	-1.1650	0.0973	0.0130
body composition	bone mineral content to body weight ratio	-0.0014669	0.00040373	-1.5419	0.0122	0.000632
body composition	bone mineral density of whole body scan, head excluded	-0.00092615	0.00059220	-0.94548	0.384	0.124
body composition	fat tissue mass of whole body scan, head excluded	0.94843	0.33544	1.3316	0.0665	0.00661
body composition	fat tissue mass to body weight ratio	0.025015	0.011027	1.0634	0.128	0.0274
body composition	lean tissue mass of whole body scan, head excluded	0.29917	0.32227	0.48072	0.654	0.357
body composition	lean tissue mass to body weight ratio	-0.012422	0.0097616	-0.73178	0.461	0.209
body composition	percent fat, whole body scan, head excluded	2.2135	1.0714	1.0421	0.172	0.0437
body composition	ratio of soft-tissue attenuation coefficients	-0.0024443	0.0011912	-1.0407	0.180	0.0451
body composition	tissue area	0.44720	0.19622	1.4573	0.169	0.0267
body composition	total tissue mass, whole body scan, head excluded	1.0599	0.25102	1.8067	0.00336	0.0000953
clinical blood chemistry	alanine transaminase (plasma ALT)	-3.8980	5.8464	-0.37489	0.808	0.509
clinical blood chemistry	albumin (plasma Alb)	-0.0080831	0.44607	0.055636	0.994	0.986
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.6031	2.4167	0.11289	0.369	0.144
clinical blood chemistry	aspartate transaminase (plasma AST)	-8.2635	17.889	-0.40340	0.865	0.647
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.11629	0.30650	-0.35810	0.912	0.706
clinical blood chemistry	blood urea nitrogen (BUN)	0.14479	1.0556	0.010749	0.946	0.892
clinical blood chemistry	calcium (plasma Ca)	-0.049864	0.065989	-0.012086	0.679	0.454
clinical blood chemistry	creatinine (plasma)	0.00051752	0.016607	0.12185	0.988	0.975
clinical blood chemistry	glucose (plasma GLU, no fast)	-3.3377	10.275	0.16572	0.859	0.747
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.1908	2.3486	-0.79372	0.648	0.357
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0085845	0.0082365	0.33873	0.632	0.303
clinical blood chemistry	phosphorus (plasma phosphate)	-0.12426	0.23208	-0.24541	0.809	0.595
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0076510	0.0062484	-0.58365	0.576	0.228
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-3.6579	2.9814	-0.84487	0.541	0.227
clinical blood chemistry	total protein (plasma TP)	-0.52736	0.62461	-0.46757	0.653	0.404
clinical blood chemistry	triglyceride (plasma TG, no fast)	-12.827	8.3786	-0.48475	0.404	0.134
EKG	duration of PQ interval	1.6387	1.0519	1.7869	0.713	0.142
EKG	duration of PR interval	0.089986	1.0518	0.18440	0.985	0.933
EKG	duration of QRS interval	-0.070853	0.35147	-0.33245	0.988	0.843
EKG	duration of QT interval	-0.72342	1.1234	-0.55048	0.898	0.530
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.61829	0.93016	0.73916	0.924	0.517
EKG	duration of RR interval	-5.1068	2.2155	-1.9897	0.368	0.0370
EKG	duration of ST interval	-0.77422	1.0413	-0.54579	0.861	0.469
EKG	heart rate coefficient of variation (signal intensity)	-3.3460	1.3200	-2.3398	0.623	0.0238
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-20.988	8.5592	-2.3098	0.697	0.0279
EKG	heart rate, beats per min	36.694	16.731	1.8609	0.355	0.0457
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.22081	0.13691	1.5453	0.474	0.129
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.14515	0.16443	0.76261	0.708	0.392
EKG	number of signals	5.4107	7.0014	1.0046	0.862	0.452
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-22.439	8.2153	-3.1517	0.662	0.0162
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-8.4278	3.7119	-2.1843	0.832	0.0395
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-8.9268	3.7943	-2.0198	0.748	0.0338
EKG	root mean square of successive differences of neighboring RR intervals	-3.5434	2.2924	-1.7485	0.843	0.144
glucose tolerance test	amount glucose injected	-3.0073	2.9875	-0.50228	0.692	0.326
glucose tolerance test	plasma glucose, 0min	-4.5635	6.1014	-0.68053	0.675	0.462
glucose tolerance test	plasma glucose, 15min	1.5640	29.781	0.13632	0.984	0.959
glucose tolerance test	plasma glucose, 30min	-30.298	26.239	-0.82839	0.599	0.261
glucose tolerance test	plasma glucose, 60min	-37.038	21.346	-1.4128	0.362	0.0967
glucose tolerance test	plasma glucose, 120min	1.2703	12.231	-0.045316	0.962	0.918
grip strength	body weight (at time of grip strength test)	-0.20914	0.56020	0.013056	0.832	0.711
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-9.3451	12.238	-0.42172	0.651	0.450
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.40539	0.59174	-0.39802	0.687	0.497
grip strength	forelimb and hindlimb grip strength by trial, trial1	3.3097	10.859	0.47146	0.903	0.762
grip strength	forelimb and hindlimb grip strength by trial, trial2	-14.049	10.963	-0.65547	0.453	0.207
grip strength	forelimb and hindlimb grip strength by trial, trial3	5.2271	12.334	0.55261	0.848	0.674
grip strength	forelimb grip strength (mean of trials), average	-7.6514	4.9624	-0.70303	0.359	0.131
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-12.512	11.761	-2.9221	0.571	0.294
grip strength	forelimb grip strength by trial, trial1	-7.6142	5.0577	-0.63401	0.449	0.140
grip strength	forelimb grip strength by trial, trial2	-0.72148	6.3431	0.14574	0.963	0.910
grip strength	forelimb grip strength by trial, trial3	-2.8548	6.4686	-0.058124	0.865	0.661
heart weight	heart weight, normalized to body weight	0.070819	0.10941	-0.19790	0.708	0.521
heart weight	heart weight, weight	-0.47113	3.4234	-0.42530	0.940	0.891
hematology	basophil differential (percent of total WBC)	0.014047	0.037943	0.24966	0.920	0.713
hematology	calculated hemoglobin (cHGB)	-0.043902	0.14353	-0.41678	0.885	0.761
hematology	eosinophil differential (percent of total WBC)	-0.12823	0.18050	-0.28056	0.815	0.481
hematology	hematocrit (HCT)	0.19275	0.38431	-0.17030	0.802	0.619
hematology	hemoglobin concentration distribution width (HDW)	-0.00025210	0.019052	-0.0052149	0.994	0.990
hematology	large unstained cells (percent of total WBC)	0.0072181	0.046096	0.065187	0.947	0.876
hematology	lymphocyte differential (percent of total WBC)	1.9309	1.7207	0.69610	0.524	0.268
hematology	mean corpuscular hemoglobin (CHr)	-0.028201	0.056857	-0.20960	0.810	0.623
hematology	mean platelet volume (MPV)	0.16923	0.056556	0.83655	0.0319	0.00473
hematology	mean RBC corpuscular hemoglobin (MCH)	0.081935	0.14810	0.30333	0.821	0.583
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.070688	0.36672	0.18877	0.949	0.848
hematology	mean RBC corpuscular volume (MCV)	0.17058	0.27122	0.33414	0.739	0.533
hematology	measured hemoglobin (mHGB)	0.055506	0.20615	-0.099307	0.904	0.789
hematology	monocyte differential (percent of total WBC)	-0.095753	0.13564	-0.11369	0.775	0.484
hematology	neutrophil differential (percent of total WBC)	-1.7759	1.6321	-0.75478	0.530	0.283
hematology	platelet count (PLT; units per volume x 10³)	-37.595	34.812	-0.45384	0.646	0.286
hematology	RBC corpuscular distribution width (RDW)	0.043100	0.13527	0.15480	0.869	0.752
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.20857	0.16035	-0.60402	0.450	0.201
hematology	red blood cell count (RBC; per volume x 10⁶)	0.0048100	0.11330	-0.33451	0.980	0.966
hematology	reticulocyte count (Retic; units per volume x 10⁹)	9.0541	19.339	0.48462	0.879	0.642
hematology	reticulocyte differential (percent of total RBC)	0.074033	0.19406	0.53559	0.881	0.705
hematology	white blood cell count (WBC; units per volume x 10³)	0.89606	0.56968	0.78232	0.287	0.123
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.29910	0.73740	-0.23595	0.915	0.686
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.69058	0.41506	1.2720	0.626	0.101
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.13285	0.34614	0.32019	0.937	0.702
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.54739	0.72389	-0.49080	0.824	0.452
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.031094	0.43814	0.061650	0.985	0.944
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.23783	0.20915	0.68192	0.834	0.259
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.077828	0.37744	0.20683	0.983	0.837
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.37864	0.41591	0.77607	0.807	0.366
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.60932	0.38953	1.1166	0.573	0.122
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.39714	0.31201	1.0172	0.759	0.207
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.87891	0.29946	1.7858	0.452	0.00455
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.27152	0.42305	0.55720	0.874	0.523
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.55639	0.66916	0.62963	0.761	0.409
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.45932	0.39531	0.79726	0.683	0.249
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.76887	0.39987	1.2390	0.481	0.0587
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.52944	0.63189	-0.43690	0.754	0.405
holeboard	total number of hole pokes, 20 min test	3.6708	3.2015	0.60514	0.552	0.256
light / dark	fecal boli count, 20 min test	0.63768	0.66171	0.75299	0.735	0.340
light / dark	latency to enter dark zone, 20 min test	93.023	37.145	1.4359	0.236	0.0146
light / dark	number of transitions between light and dark zones, 20 min test	-11.435	6.5153	-1.0390	0.355	0.0836
light / dark	percentage of total time in dark zone, 20 min test	4.4965	2.5497	0.91685	0.405	0.0822
light / dark	percentage of total time in light zone, 20 min test	-4.4965	2.5497	-0.92719	0.403	0.0822
light / dark	time mobile in dark zone, 20 min test	-24.236	10.564	-1.4246	0.159	0.0248
light / dark	time mobile in light zone, 20 min test	-13.669	8.9187	-1.2206	0.358	0.130
light / dark	time spent in dark zone, 20 min test	-34.602	40.612	-0.30763	0.758	0.397
light / dark	time spent in light zone, 20 min test	34.602	40.612	0.30763	0.758	0.397
open field	average speed in center of arena, 20 min test	-0.34967	0.35429	-0.72378	0.662	0.327
open field	average speed in periphery of arena, 20 min test	-0.042586	0.12126	-0.70300	0.853	0.727
open field	distance traveled habituation ratio, 20 min test	-12.331	6.9413	-1.0365	0.346	0.0802
open field	distance traveled in center of arena, 20 min test	-50.038	58.725	-0.69272	0.646	0.397
open field	distance traveled in periphery of arena, 20 min test	-65.682	132.87	-0.69102	0.796	0.623
open field	distance traveled slope, 20 min test	-11.752	6.4882	-1.0229	0.335	0.0746
open field	distance traveled, 20 min test, 1st 5min	31.303	50.145	-0.078623	0.755	0.535
open field	distance traveled, 20 min test, 2nd 5min	-10.088	44.738	-0.62108	0.914	0.822
open field	distance traveled, 20 min test, 3rd 5min	-34.130	47.764	-0.81214	0.712	0.477
open field	distance traveled, 20 min test, 4th 5min	-86.486	49.751	-1.4100	0.265	0.0868
open field	number of clockwise revolution episodes, 20 min test	-1.3159	0.89376	-1.2330	0.487	0.146
open field	number of counter-clockwise revolution episodes, 20 min test	-1.0550	0.98920	-0.98945	0.573	0.290
open field	number of fecal boli, 20 min test	-1.5566	0.70722	-0.99165	0.224	0.0318
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.2603	1.7653	0.13745	0.719	0.478
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.064814	2.1225	-0.33723	0.991	0.976
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.0075	2.4677	-0.082664	0.843	0.684
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.6911	2.5826	-0.71682	0.741	0.515
open field	percentage of total time in center of arena, 20 min test	0.65939	2.2867	-0.040961	0.915	0.774
open field	percentage of total time in center of arena, slope, 20 min test	2.1899	1.2541	1.3376	0.528	0.0854
open field	percentage of total time in center, habituation ratio, 20 min test	2.0982	1.2574	1.2566	0.543	0.0998
open field	percentage of total time in corners of arena, 20 min test	-0.20586	3.5084	0.28229	0.980	0.953
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.70165	1.5247	-0.62597	0.931	0.647
open field	percentage of total time in corners, slope, 20 min test	-0.58411	1.4793	-0.54937	0.933	0.694
open field	permanence time in center of arena, 20 min test	7.9201	27.440	-0.039617	0.916	0.774
open field	permanence time in corners of arena, 20 min test	-2.4851	42.100	0.28229	0.980	0.953
open field	permanence time in periphery of arena, 20 min test	-7.9071	27.440	0.039617	0.916	0.774
open field	total distance traveled, 20 min test	-99.731	148.54	-0.79545	0.703	0.504
open field	total number of rears, 20 min test	-0.61465	7.4973	-0.38164	0.975	0.935
open field	whole arena average speed, 20 min test	-0.084576	0.12360	-0.79545	0.698	0.496
open field	whole arena resting time, 20 min test	9.2109	15.020	0.80655	0.716	0.542
open field	whole arena time spent mobile, 20 min test	-9.1382	15.002	-0.95287	0.722	0.544
open field	whole arena time spent vertical, 20 min test	-5.0839	7.8156	-0.54469	0.780	0.518
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.0437	1.2999	-0.68423	0.418	0.122
startle / PPI	average baseline movement during background noise	-2.9180	1.3455	-1.8863	0.478	0.0345
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.070163	0.065242	0.54981	0.641	0.287
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.079868	0.063206	0.71330	0.561	0.212
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.2686	8.6298	0.83525	0.879	0.403
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.7063	6.1408	0.62474	0.645	0.280
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.3097	5.4374	0.24699	0.805	0.545
startle / PPI	average startle response to full pulse (120 dB)	-36.785	46.071	-0.50314	0.666	0.428
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-53.956	45.795	-0.80388	0.484	0.244
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-46.077	38.524	-0.72506	0.457	0.237
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-33.858	34.990	-0.61456	0.563	0.337
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.6439	1.9243	-1.1148	0.832	0.397
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.024976	1.4469	0.0049040	0.998	0.986
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-2.0325	1.9904	-1.2083	0.728	0.312
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.088867	0.094993	0.87771	0.869	0.354
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.10177	0.070292	0.78767	0.493	0.153
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.046887	0.065847	0.22047	0.724	0.479
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-33.197	46.027	-0.44203	0.705	0.474
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-52.981	45.906	-0.77329	0.491	0.253
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-46.215	38.707	-0.71236	0.454	0.238
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-31.896	35.419	-0.54818	0.584	0.372
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.061947	0.095552	0.56290	0.918	0.519
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.10547	0.071176	0.73377	0.475	0.144
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.039382	0.069098	0.11803	0.777	0.571
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-150.34	172.54	-0.55634	0.624	0.387
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-210.78	172.38	-0.87565	0.463	0.227
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-181.93	147.97	-0.76388	0.440	0.224
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-124.31	137.23	-0.57608	0.578	0.369
startle / PPI	maximum baseline movement during background noise	-5.9314	3.2967	-1.5287	0.539	0.0775
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.2636	9.0228	0.56948	0.937	0.562
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.8411	6.4764	0.52392	0.647	0.295
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	2.6627	6.1348	0.10457	0.854	0.666
startle / PPI	maximum startle response to full pulse (120 dB)	-156.44	172.47	-0.58936	0.603	0.368
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-213.57	172.52	-0.88391	0.461	0.221
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-178.22	147.56	-0.73053	0.451	0.232
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-129.25	136.33	-0.62815	0.564	0.347
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-4.0430	4.8444	-1.0890	0.800	0.408
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	3.0231	3.5457	0.80388	0.803	0.398
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-5.0091	4.9027	-1.2439	0.694	0.311

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

Download Plot

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	12.0 %	0.0788
eye morphology	cornea	both	5.0 %	0.344
eye morphology	cornea opacity	females	32.0 %	0.00443
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	15.0 %	0.00953
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	12.0 %	0.105
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	6.0 %	0.180
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	41.0 %	0.000997
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	18.0 %	0.00943
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	6.0 %	0.690
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	3.0 %	0.790
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	22.0 %	0.155
eye morphology	retina	both	8.0 %	0.428
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	12.0 %	0.0346
eye morphology	retinal blood vessels pattern	both	6.0 %	0.173
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	10.0 %	0.522
eye morphology	retinal pigmentation	males	10.0 %	0.432
eye morphology	retinal pigmentation	both	5.0 %	0.496
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Spata31d1d^em1(IMPC)J/Mmjax -/- with genotype: