MPD: JaxKOMP-EAP genotype: Xkr4<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Xkr4^em1(IMPC)J/Mmjax -/- Gene Xkr4

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-1.4401	1.8509	-0.70003	0.812	0.449
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	5.7330	5.2343	1.1371	0.735	0.291
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-2.9959	3.4624	-0.80770	0.741	0.401
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.8344	3.0904	-0.40258	0.826	0.562
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-7.5503	2.3693	-1.0912	0.112	0.00613
body composition	body length	0.065441	0.047330	1.0620	0.461	0.175
body composition	body weight (at time of DXA)	1.6640	0.84795	1.4905	0.184	0.0569
body composition	bone area, whole body scan, head excluded	-0.44188	0.11321	-1.4120	0.00926	0.000365
body composition	bone mineral content of whole body scan, head excluded	-0.011930	0.0099705	-0.51471	0.524	0.239
body composition	bone mineral content to body weight ratio	-0.00099377	0.00038152	-1.0468	0.0911	0.0130
body composition	bone mineral density of whole body scan, head excluded	-0.000022533	0.00075422	0.0020490	0.994	0.976
body composition	fat tissue mass of whole body scan, head excluded	0.63933	0.37593	0.95227	0.299	0.0972
body composition	fat tissue mass to body weight ratio	0.016393	0.012877	0.76837	0.439	0.211
body composition	lean tissue mass of whole body scan, head excluded	0.90223	0.43434	1.5113	0.231	0.0446
body composition	lean tissue mass to body weight ratio	0.011204	0.011600	0.55681	0.597	0.340
body composition	percent fat, whole body scan, head excluded	1.0743	1.2429	0.57812	0.636	0.393
body composition	ratio of soft-tissue attenuation coefficients	-0.0011813	0.0013799	-0.58116	0.638	0.397
body composition	tissue area	0.31297	0.26751	1.1147	0.549	0.249
body composition	total tissue mass, whole body scan, head excluded	1.5562	0.34962	2.4818	0.00283	0.0000725
clinical blood chemistry	alanine transaminase (plasma ALT)	3.8131	10.181	0.33414	0.918	0.713
clinical blood chemistry	albumin (plasma Alb)	-0.17050	0.61768	-0.20824	0.925	0.786
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-6.3620	4.4782	-1.6048	0.413	0.175
clinical blood chemistry	aspartate transaminase (plasma AST)	-0.24562	25.015	-0.017014	0.998	0.992
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.13991	0.44680	-0.44270	0.930	0.758
clinical blood chemistry	blood urea nitrogen (BUN)	-2.7018	1.1862	-1.0955	0.178	0.0368
clinical blood chemistry	calcium (plasma Ca)	0.044409	0.11086	0.64576	0.830	0.694
clinical blood chemistry	creatinine (plasma)	-0.011314	0.024007	-0.17764	0.814	0.645
clinical blood chemistry	glucose (plasma GLU, no fast)	7.7454	12.470	0.59712	0.727	0.544
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.050707	3.2219	-0.30878	0.998	0.988
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.017965	0.011565	-1.0843	0.461	0.140
clinical blood chemistry	phosphorus (plasma phosphate)	-0.081388	0.40785	-0.18705	0.936	0.844
clinical blood chemistry	total bilirubin (plasma TBIL)	0.014406	0.015070	0.93031	0.696	0.354
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.0078	4.5782	-0.057615	0.935	0.829
clinical blood chemistry	total protein (plasma TP)	0.88596	0.65801	0.60786	0.478	0.197
clinical blood chemistry	triglyceride (plasma TG, no fast)	18.377	15.719	1.1071	0.559	0.261
EKG	duration of PQ interval	-0.063393	1.0845	0.072603	0.986	0.954
EKG	duration of PR interval	0.37589	1.1312	0.48141	0.938	0.743
EKG	duration of QRS interval	0.47143	0.37762	1.2301	0.885	0.224
EKG	duration of QT interval	-1.3277	1.0375	-1.0524	0.704	0.213
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.075000	0.85106	0.14763	0.999	0.931
EKG	duration of RR interval	-5.9100	2.1479	-2.2553	0.258	0.0116
EKG	duration of ST interval	-1.8494	0.84472	-1.5069	0.460	0.0390
EKG	heart rate coefficient of variation (signal intensity)	-2.6074	1.0744	-2.0355	0.623	0.0239
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-17.316	7.5254	-1.9089	0.697	0.0312
EKG	heart rate, beats per min	45.809	15.606	2.1226	0.176	0.00766
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.12661	0.10121	0.83760	0.600	0.224
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.26193	0.12950	1.4351	0.316	0.0549
EKG	number of signals	-8.7459	4.0528	-1.4945	0.472	0.0416
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-14.490	5.9504	-2.3686	0.715	0.0235
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-5.2321	2.8021	-1.4884	0.858	0.0747
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-3.5759	3.1850	-0.96849	0.875	0.273
EKG	root mean square of successive differences of neighboring RR intervals	-2.5551	1.7699	-1.3259	0.843	0.162
glucose tolerance test	amount glucose injected	-6.6141	3.7337	-1.4423	0.406	0.0847
glucose tolerance test	plasma glucose, 0min	-0.68625	3.6100	-0.30819	0.927	0.850
glucose tolerance test	plasma glucose, 15min	-37.843	16.064	-0.90432	0.184	0.0237
glucose tolerance test	plasma glucose, 30min	-27.795	19.756	-0.74242	0.505	0.168
glucose tolerance test	plasma glucose, 60min	2.1866	13.601	0.21581	0.946	0.873
glucose tolerance test	plasma glucose, 120min	8.4153	9.6723	0.43928	0.671	0.390
grip strength	body weight (at time of grip strength test)	0.43970	0.52345	0.61204	0.600	0.406
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-6.3833	6.0885	-0.22704	0.514	0.301
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.61485	0.40119	1.1004	0.310	0.134
grip strength	forelimb and hindlimb grip strength by trial, trial1	-5.4647	9.6172	-0.13841	0.805	0.573
grip strength	forelimb and hindlimb grip strength by trial, trial2	-13.234	8.9030	-0.60585	0.374	0.145
grip strength	forelimb and hindlimb grip strength by trial, trial3	-2.4870	7.8292	0.039222	0.894	0.752
grip strength	forelimb grip strength (mean of trials), average	-0.27333	4.2139	0.22555	0.984	0.949
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.41327	0.27021	1.2108	0.380	0.134
grip strength	forelimb grip strength by trial, trial1	1.4120	5.9117	0.42807	0.926	0.813
grip strength	forelimb grip strength by trial, trial2	0.98954	6.8770	0.31902	0.957	0.886
grip strength	forelimb grip strength by trial, trial3	-3.2902	7.0585	-0.10622	0.854	0.644
heart weight	heart weight, normalized to body weight	-0.16741	0.14130	-1.1192	0.470	0.251
heart weight	heart weight, weight	-0.78563	4.2422	-0.46559	0.920	0.855
hematology	basophil differential (percent of total WBC)	0.070617	0.070594	1.0039	0.741	0.333
hematology	calculated hemoglobin (cHGB)	0.69029	0.26506	1.7402	0.146	0.0199
hematology	eosinophil differential (percent of total WBC)	-0.34229	0.24425	-0.84084	0.574	0.181
hematology	hematocrit (HCT)	2.6152	0.76347	2.0730	0.0606	0.00376
hematology	hemoglobin concentration distribution width (HDW)	0.022747	0.077021	0.62617	0.898	0.772
hematology	large unstained cells (percent of total WBC)	0.0079691	0.15445	0.070410	0.983	0.960
hematology	lymphocyte differential (percent of total WBC)	2.2043	1.4088	0.76573	0.385	0.139
hematology	mean corpuscular hemoglobin (CHr)	0.10202	0.065485	0.81358	0.346	0.140
hematology	mean platelet volume (MPV)	0.34910	0.13939	1.4057	0.107	0.0252
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.025856	0.15926	-0.12487	0.954	0.873
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.61051	0.42801	-1.0098	0.533	0.174
hematology	mean RBC corpuscular volume (MCV)	0.66418	0.46842	1.1405	0.374	0.177
hematology	measured hemoglobin (mHGB)	0.59862	0.36857	1.2856	0.402	0.125
hematology	monocyte differential (percent of total WBC)	0.018117	0.28887	0.26834	0.982	0.951
hematology	neutrophil differential (percent of total WBC)	-2.0588	1.2890	-0.86285	0.355	0.131
hematology	platelet count (PLT; units per volume x 10³)	-59.873	28.597	-0.73673	0.334	0.0537
hematology	RBC corpuscular distribution width (RDW)	0.10606	0.20474	0.36056	0.796	0.612
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.27203	0.24576	-0.74849	0.548	0.286
hematology	red blood cell count (RBC; per volume x 10⁶)	0.46067	0.19754	1.5921	0.191	0.0340
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-30.776	55.766	-1.1777	0.854	0.589
hematology	reticulocyte differential (percent of total RBC)	-0.56007	0.70477	-1.8572	0.754	0.439
hematology	white blood cell count (WBC; units per volume x 10³)	1.0536	0.76929	0.88892	0.391	0.191
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.22024	0.63560	-0.16875	0.926	0.730
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.42149	0.47082	-0.54681	0.818	0.375
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.67560	0.51884	-1.0710	0.719	0.199
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.42262	0.66993	-0.34517	0.859	0.531
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.43458	0.36410	-0.61883	0.736	0.238
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.58591	0.21727	-1.6534	0.384	0.00947
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.57912	0.22237	-1.6458	0.527	0.0120
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.63690	0.42166	-0.93165	0.695	0.137
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.26795	0.39022	0.57589	0.878	0.495
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.40179	0.23096	-1.1479	0.681	0.0880
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.14881	0.27014	-0.37515	0.910	0.584
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.23482	0.37357	-0.31022	0.881	0.532
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.62682	0.76027	-0.54542	0.768	0.414
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.10060	0.46343	-0.087828	0.963	0.829
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.58929	0.39349	-0.84451	0.629	0.140
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.96803	0.69901	0.87132	0.588	0.172
holeboard	total number of hole pokes, 20 min test	-4.6048	3.5753	-0.57502	0.488	0.204
light / dark	fecal boli count, 20 min test	0.73604	0.71695	0.84220	0.715	0.311
light / dark	latency to enter dark zone, 20 min test	222.01	54.852	2.6264	0.0544	0.000180
light / dark	number of transitions between light and dark zones, 20 min test	-23.939	8.0838	-2.0775	0.0775	0.00464
light / dark	percentage of total time in dark zone, 20 min test	0.060796	4.2971	0.13698	0.995	0.989
light / dark	percentage of total time in light zone, 20 min test	-0.060796	4.2971	-0.14381	0.995	0.989
light / dark	time mobile in dark zone, 20 min test	-55.139	12.873	-2.5860	0.00290	0.0000815
light / dark	time mobile in light zone, 20 min test	-13.153	10.518	-1.1817	0.474	0.217
light / dark	time spent in dark zone, 20 min test	-150.47	58.799	-1.7644	0.202	0.0135
light / dark	time spent in light zone, 20 min test	150.47	58.799	1.7644	0.202	0.0135
open field	average speed in center of arena, 20 min test	-1.1224	0.38458	-2.1168	0.0891	0.00530
open field	average speed in periphery of arena, 20 min test	-0.45930	0.11471	-2.0465	0.00372	0.000215
open field	distance traveled habituation ratio, 20 min test	19.049	7.2729	1.5114	0.127	0.0117
open field	distance traveled in center of arena, 20 min test	-67.578	54.953	-0.79361	0.479	0.225
open field	distance traveled in periphery of arena, 20 min test	-534.70	122.71	-2.4592	0.00179	0.0000672
open field	distance traveled slope, 20 min test	16.663	6.8120	1.4173	0.166	0.0181
open field	distance traveled, 20 min test, 1st 5min	-260.68	61.645	-2.1043	0.00284	0.000105
open field	distance traveled, 20 min test, 2nd 5min	-116.54	46.959	-1.7364	0.0940	0.0166
open field	distance traveled, 20 min test, 3rd 5min	-127.52	40.760	-1.7364	0.0307	0.00296
open field	distance traveled, 20 min test, 4th 5min	-93.709	46.549	-1.4948	0.197	0.0497
open field	number of clockwise revolution episodes, 20 min test	-1.4202	1.0861	-1.2926	0.552	0.197
open field	number of counter-clockwise revolution episodes, 20 min test	-1.7027	1.0974	-1.3475	0.389	0.127
open field	number of fecal boli, 20 min test	0.55406	0.92356	0.65536	0.794	0.554
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-4.8247	1.4714	-1.4986	0.0344	0.00192
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-4.5831	1.9672	-1.4511	0.147	0.0240
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-5.0782	2.5489	-1.4472	0.228	0.0519
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-4.0309	2.4450	-1.2079	0.345	0.106
open field	percentage of total time in center of arena, 20 min test	0.47497	1.9495	-0.084011	0.931	0.809
open field	percentage of total time in center of arena, slope, 20 min test	-2.1045	1.0430	-0.96993	0.436	0.0491
open field	percentage of total time in center, habituation ratio, 20 min test	-2.0362	1.0465	-0.91141	0.464	0.0574
open field	percentage of total time in corners of arena, 20 min test	11.738	4.1858	2.1562	0.0928	0.00721
open field	percentage of total time in corners, habituation ratio, 20 min test	2.0901	1.9346	0.67913	0.781	0.285
open field	percentage of total time in corners, slope, 20 min test	1.9892	1.8966	0.64569	0.779	0.299
open field	permanence time in center of arena, 20 min test	5.7197	23.396	-0.082664	0.931	0.808
open field	permanence time in corners of arena, 20 min test	140.84	50.230	2.1562	0.0928	0.00722
open field	permanence time in periphery of arena, 20 min test	-5.7245	23.394	0.082664	0.931	0.808
open field	total distance traveled, 20 min test	-617.61	157.01	-2.0804	0.00417	0.000263
open field	total number of rears, 20 min test	-18.306	6.8920	-1.5284	0.0791	0.0106
open field	whole arena average speed, 20 min test	-0.51336	0.13086	-2.0688	0.00427	0.000273
open field	whole arena resting time, 20 min test	56.722	16.375	2.0252	0.0111	0.00113
open field	whole arena time spent mobile, 20 min test	-56.708	16.370	-2.3400	0.0118	0.00113
open field	whole arena time spent vertical, 20 min test	-20.514	7.5171	-1.6064	0.0928	0.00880
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-3.4111	1.4563	-1.2686	0.181	0.0244
startle / PPI	average baseline movement during background noise	2.7965	1.4809	1.5517	0.565	0.0670
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.10390	0.063373	0.84923	0.435	0.110
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.087562	0.060435	0.78767	0.493	0.156
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.0670	6.6333	0.60780	0.882	0.450
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	12.459	7.2042	1.2112	0.425	0.0921
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	2.3897	6.4414	0.15545	0.895	0.713
startle / PPI	average startle response to full pulse (120 dB)	-156.12	38.115	-2.0870	0.00405	0.000220
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-163.70	40.271	-2.1826	0.00453	0.000241
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-157.18	36.730	-2.2656	0.00267	0.000127
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-105.79	32.593	-1.9669	0.0249	0.00249
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.39283	1.9726	-0.23833	0.973	0.843
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.24084	1.6235	-0.15829	0.978	0.883
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	3.9242	1.9088	1.3006	0.374	0.0469
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.028889	0.073903	0.32731	0.940	0.698
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.13963	0.074890	1.0609	0.355	0.0702
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.093320	0.071978	0.55751	0.455	0.203
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-159.20	37.898	-2.1677	0.00309	0.000161
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-163.65	39.971	-2.1677	0.00411	0.000221
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-157.08	36.456	-2.2656	0.00254	0.000116
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-109.62	32.646	-1.9767	0.0204	0.00183
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.025708	0.076071	0.26001	0.954	0.737
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.15699	0.078621	1.1409	0.304	0.0532
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.12718	0.076340	0.73377	0.314	0.104
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-523.74	131.93	-1.9206	0.00532	0.000319
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-545.73	146.76	-1.9969	0.00889	0.000661
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-553.28	135.69	-2.2656	0.00432	0.000232
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-395.70	123.56	-1.9669	0.0264	0.00280
startle / PPI	maximum baseline movement during background noise	8.4473	3.9213	1.7543	0.439	0.0380
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.9912	6.8078	0.52553	0.911	0.468
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	14.840	7.6348	1.3038	0.361	0.0596
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.7350	6.8894	0.39765	0.688	0.411
startle / PPI	maximum startle response to full pulse (120 dB)	-514.73	132.33	-1.9032	0.00637	0.000403
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-548.43	147.38	-2.0179	0.00876	0.000656
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-553.92	136.36	-2.2477	0.00448	0.000243
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-384.18	123.38	-1.9206	0.0320	0.00356
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.5346	5.2195	-0.95225	0.854	0.503
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.18764	3.6130	-0.042748	0.996	0.959
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	11.740	4.8749	1.4979	0.239	0.0211

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	12.0 %	0.175
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	6.0 %	0.248
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	12.0 %	0.134
eye morphology	persistence of hyaloid vascular system	both	5.0 %	0.564
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	7.0 %	0.375
SHIRPA	limb grasp	both	5.0 %	0.327
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.00788
SHIRPA	tail elevation	males	25.0 %	0.000219
SHIRPA	tail elevation	both	19.0 %	0.00000208
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Xkr4^em1(IMPC)J/Mmjax -/- with genotype: