MPD: JaxKOMP-EAP genotype: Tnks1bp1<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Tnks1bp1^em1(IMPC)J -/- Gene Tnks1bp1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.41667	1.5623	-0.15622	0.947	0.807
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	2.2917	2.4185	0.54681	0.822	0.413
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.4583	2.7168	0.15183	0.871	0.629
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	18.328	2.7717	2.1808	0.113	0.00704
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	11.369	5.1200	1.6525	0.473	0.113
body composition	body length	0.052625	0.044456	0.91224	0.539	0.242
body composition	body weight (at time of DXA)	-1.5629	0.71430	-0.99428	0.130	0.0334
body composition	bone area, whole body scan, head excluded	-0.12898	0.15767	-0.33809	0.674	0.417
body composition	bone mineral content of whole body scan, head excluded	-0.0060985	0.011031	-0.23001	0.798	0.583
body composition	bone mineral content to body weight ratio	-0.00041787	0.00048064	-0.35549	0.643	0.389
body composition	bone mineral density of whole body scan, head excluded	4.5220e-7	0.00051324	0.029373	1.00	0.999
body composition	fat tissue mass of whole body scan, head excluded	0.020030	0.35335	0.024577	0.976	0.955
body composition	fat tissue mass to body weight ratio	0.00024274	0.012143	0.080638	0.996	0.984
body composition	lean tissue mass of whole body scan, head excluded	0.19758	0.34721	0.25673	0.809	0.572
body composition	lean tissue mass to body weight ratio	0.0069474	0.013915	0.31595	0.817	0.620
body composition	percent fat, whole body scan, head excluded	-0.13457	1.1822	-0.0081917	0.962	0.910
body composition	ratio of soft-tissue attenuation coefficients	0.00015149	0.0013139	0.013683	0.966	0.909
body composition	tissue area	-0.17403	0.21689	-0.40142	0.721	0.426
body composition	total tissue mass, whole body scan, head excluded	0.27773	0.21722	0.39357	0.447	0.207
clinical blood chemistry	alanine transaminase (plasma ALT)	9.6190	7.6730	0.72195	0.597	0.224
clinical blood chemistry	albumin (plasma Alb)	-1.9500	0.81633	-2.2071	0.197	0.0269
clinical blood chemistry	alkaline phosphatase (plasma ALP)	14.468	5.3054	1.5650	0.0813	0.0130
clinical blood chemistry	aspartate transaminase (plasma AST)	19.809	17.882	0.77594	0.600	0.280
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.23527	0.37885	0.76746	0.841	0.541
clinical blood chemistry	blood urea nitrogen (BUN)	-0.30497	1.6616	-0.15468	0.934	0.856
clinical blood chemistry	calcium (plasma Ca)	0.11907	0.10429	1.1296	0.497	0.267
clinical blood chemistry	creatinine (plasma)	0.012678	0.027648	0.41955	0.817	0.651
clinical blood chemistry	glucose (plasma GLU, no fast)	1.0089	13.689	0.33087	0.965	0.942
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.9096	3.0651	-0.94467	0.646	0.354
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.031839	0.011254	1.5207	0.126	0.0101
clinical blood chemistry	phosphorus (plasma phosphate)	0.15513	0.35167	0.20448	0.839	0.664
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.017143	0.013416	-1.1862	0.558	0.215
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-4.9782	3.6504	-1.0351	0.484	0.188
clinical blood chemistry	total protein (plasma TP)	-3.3081	1.0850	-2.0793	0.0759	0.00610
clinical blood chemistry	triglyceride (plasma TG, no fast)	-36.165	12.244	-1.4958	0.0786	0.00758
EKG	duration of PQ interval	1.2225	1.1250	1.3918	0.822	0.290
EKG	duration of PR interval	0.60336	1.2933	0.71294	0.938	0.646
EKG	duration of QRS interval	-0.72054	0.60348	-2.0860	0.885	0.246
EKG	duration of QT interval	-0.64032	1.0862	-0.45220	0.898	0.562
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.12500	0.86341	-0.094846	0.991	0.886
EKG	duration of RR interval	-1.6656	1.8352	-0.61983	0.773	0.375
EKG	duration of ST interval	-0.022380	1.1144	0.18645	0.995	0.984
EKG	heart rate coefficient of variation (signal intensity)	-0.36590	1.5501	-0.20494	0.968	0.816
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-2.3000	11.079	-0.16803	0.972	0.838
EKG	heart rate, beats per min	19.735	16.574	0.96154	0.650	0.248
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.22295	0.15748	1.5587	0.542	0.172
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.039250	0.14506	0.13451	0.923	0.789
EKG	number of signals	7.4500	4.3090	1.3505	0.605	0.0992
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.26659	5.2940	0.030524	0.991	0.960
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.7573	5.9884	0.55517	0.972	0.772
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	3.0315	5.9073	0.79321	0.947	0.613
EKG	root mean square of successive differences of neighboring RR intervals	0.17904	3.3192	0.20082	0.989	0.958
glucose tolerance test	amount glucose injected	-5.7650	2.9158	-1.2165	0.351	0.0591
glucose tolerance test	plasma glucose, 0min	3.4631	6.6362	0.13078	0.785	0.606
glucose tolerance test	plasma glucose, 15min	29.097	20.385	0.94645	0.468	0.164
glucose tolerance test	plasma glucose, 30min	32.700	17.827	1.0794	0.339	0.0765
glucose tolerance test	plasma glucose, 60min	-4.8594	17.109	-0.082458	0.914	0.778
glucose tolerance test	plasma glucose, 120min	-8.2125	13.379	-0.69794	0.788	0.544
grip strength	body weight (at time of grip strength test)	-0.40261	0.50637	-0.17791	0.622	0.433
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-9.4857	6.7564	-0.43445	0.361	0.171
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.38907	0.30121	-0.35128	0.404	0.207
grip strength	forelimb and hindlimb grip strength by trial, trial1	-9.6514	9.1858	-0.42330	0.609	0.302
grip strength	forelimb and hindlimb grip strength by trial, trial2	-12.532	7.7961	-0.55599	0.330	0.119
grip strength	forelimb and hindlimb grip strength by trial, trial3	-3.9114	7.7996	-0.058124	0.819	0.620
grip strength	forelimb grip strength (mean of trials), average	-4.0209	4.7017	-0.24496	0.656	0.400
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.10677	0.21377	-0.052306	0.821	0.621
grip strength	forelimb grip strength by trial, trial1	0.16744	6.2273	0.29922	0.990	0.979
grip strength	forelimb grip strength by trial, trial2	-6.6855	5.7677	-0.51410	0.578	0.256
grip strength	forelimb grip strength by trial, trial3	-3.8526	5.1864	-0.17811	0.750	0.464
heart weight	heart weight, normalized to body weight	0.20011	0.15834	0.26313	0.436	0.218
heart weight	heart weight, weight	6.0797	4.5743	0.41939	0.399	0.195
hematology	basophil differential (percent of total WBC)	0.12638	0.040329	1.5574	0.164	0.00466
hematology	calculated hemoglobin (cHGB)	0.38918	0.19064	0.95181	0.250	0.0528
hematology	eosinophil differential (percent of total WBC)	0.41499	0.18322	1.2255	0.303	0.0337
hematology	hematocrit (HCT)	1.6275	0.45737	1.3753	0.0396	0.00176
hematology	hemoglobin concentration distribution width (HDW)	0.021948	0.029377	0.60307	0.729	0.463
hematology	large unstained cells (percent of total WBC)	0.44508	0.12274	2.0662	0.0501	0.00149
hematology	lymphocyte differential (percent of total WBC)	-0.13948	1.1539	-0.099939	0.956	0.905
hematology	mean corpuscular hemoglobin (CHr)	0.0096000	0.049498	0.096238	0.927	0.848
hematology	mean platelet volume (MPV)	-0.25076	0.10455	-1.4131	0.106	0.0250
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.085013	0.11161	-0.35297	0.770	0.454
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.025894	0.27077	0.065795	0.969	0.925
hematology	mean RBC corpuscular volume (MCV)	-0.11080	0.32262	-0.19810	0.877	0.735
hematology	measured hemoglobin (mHGB)	0.37174	0.16749	0.76349	0.229	0.0366
hematology	monocyte differential (percent of total WBC)	-0.26162	0.14950	-0.64476	0.423	0.0941
hematology	neutrophil differential (percent of total WBC)	0.23536	0.87619	0.13848	0.889	0.791
hematology	platelet count (PLT; units per volume x 10³)	110.53	49.647	1.4151	0.289	0.0366
hematology	RBC corpuscular distribution width (RDW)	0.062228	0.22224	0.22739	0.890	0.782
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.043975	0.36255	0.10813	0.955	0.905
hematology	red blood cell count (RBC; per volume x 10⁶)	0.29259	0.13207	0.93163	0.203	0.0369
hematology	reticulocyte count (Retic; units per volume x 10⁹)	28.925	12.554	1.2287	0.302	0.0306
hematology	reticulocyte differential (percent of total RBC)	0.20592	0.10462	1.0093	0.362	0.0612
hematology	white blood cell count (WBC; units per volume x 10³)	1.1304	0.50385	0.91561	0.130	0.0348
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.95176	0.50436	0.93950	0.485	0.0658
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.62827	0.48743	-0.82965	0.729	0.204
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.75820	0.50544	1.2031	0.661	0.141
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.99966	0.55711	1.0650	0.524	0.0798
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.38221	0.38327	0.72023	0.788	0.324
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.028355	0.24179	0.13876	0.988	0.907
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.35563	0.20213	0.90244	0.716	0.0855
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.10941	0.41775	-0.095515	0.963	0.795
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.15480	0.39683	0.38787	0.941	0.698
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.018854	0.21993	0.12549	0.984	0.932
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.18415	0.24208	0.49020	0.870	0.451
holeboard	number of hole pokes by individual hole number, 20 min test, 12	1.0314	0.31704	1.5846	0.129	0.00220
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.70055	0.67667	0.77885	0.718	0.306
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.78362	0.47111	-1.1727	0.537	0.103
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.49004	0.39250	0.85419	0.671	0.218
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.63554	0.88523	0.59504	0.812	0.477
holeboard	total number of hole pokes, 20 min test	5.7613	3.1511	0.87132	0.300	0.0743
light / dark	fecal boli count, 20 min test	1.1114	0.80184	1.1968	0.581	0.172
light / dark	latency to enter dark zone, 20 min test	65.403	44.447	1.0506	0.583	0.148
light / dark	number of transitions between light and dark zones, 20 min test	-2.3166	8.9514	-0.11518	0.914	0.797
light / dark	percentage of total time in dark zone, 20 min test	2.5685	3.7839	0.58464	0.785	0.501
light / dark	percentage of total time in light zone, 20 min test	-2.5685	3.7839	-0.58785	0.784	0.501
light / dark	time mobile in dark zone, 20 min test	7.6231	11.346	0.38809	0.764	0.505
light / dark	time mobile in light zone, 20 min test	4.2964	12.436	0.040571	0.874	0.731
light / dark	time spent in dark zone, 20 min test	-34.993	47.987	-0.31757	0.812	0.469
light / dark	time spent in light zone, 20 min test	34.993	47.987	0.31757	0.812	0.469
open field	average speed in center of arena, 20 min test	1.2768	0.48200	1.8654	0.131	0.0109
open field	average speed in periphery of arena, 20 min test	0.31125	0.15629	0.66567	0.169	0.0520
open field	distance traveled habituation ratio, 20 min test	1.1937	6.5037	0.13670	0.945	0.855
open field	distance traveled in center of arena, 20 min test	73.443	94.878	0.12857	0.683	0.443
open field	distance traveled in periphery of arena, 20 min test	312.47	148.90	0.76631	0.166	0.0411
open field	distance traveled slope, 20 min test	0.55874	6.1080	0.12722	0.990	0.927
open field	distance traveled, 20 min test, 1st 5min	94.830	70.933	0.42975	0.417	0.188
open field	distance traveled, 20 min test, 2nd 5min	73.993	55.778	0.32730	0.419	0.191
open field	distance traveled, 20 min test, 3rd 5min	118.45	54.837	0.82339	0.153	0.0357
open field	distance traveled, 20 min test, 4th 5min	124.97	53.068	0.89326	0.123	0.0226
open field	number of clockwise revolution episodes, 20 min test	0.68503	1.2147	-0.0080600	0.826	0.575
open field	number of counter-clockwise revolution episodes, 20 min test	3.0345	1.6988	1.1539	0.309	0.0802
open field	number of fecal boli, 20 min test	0.31404	0.84000	0.49368	0.868	0.710
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.4140	2.1461	0.18372	0.743	0.513
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	3.3557	2.2783	0.51994	0.421	0.147
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	3.4760	2.8408	0.51380	0.503	0.227
open field	number of rears in 5 min bins, 20 min test, 4th 5min	4.3686	3.0614	0.60811	0.425	0.160
open field	percentage of total time in center of arena, 20 min test	-1.9170	2.8824	-0.67070	0.781	0.509
open field	percentage of total time in center of arena, slope, 20 min test	-2.0301	1.8900	-0.93194	0.747	0.288
open field	percentage of total time in center, habituation ratio, 20 min test	-1.7407	2.0246	-0.79361	0.826	0.394
open field	percentage of total time in corners of arena, 20 min test	4.5436	3.0755	1.1181	0.446	0.146
open field	percentage of total time in corners, habituation ratio, 20 min test	4.0503	1.9092	1.4549	0.415	0.0390
open field	percentage of total time in corners, slope, 20 min test	4.5791	1.7675	1.7012	0.259	0.0126
open field	permanence time in center of arena, 20 min test	-22.996	34.587	-0.66902	0.782	0.509
open field	permanence time in corners of arena, 20 min test	54.520	36.905	1.1181	0.447	0.146
open field	permanence time in periphery of arena, 20 min test	23.069	34.587	0.66902	0.781	0.508
open field	total distance traveled, 20 min test	435.23	205.57	0.74310	0.142	0.0393
open field	total number of rears, 20 min test	12.250	8.9587	0.48490	0.414	0.178
open field	whole arena average speed, 20 min test	0.36134	0.17133	0.73605	0.144	0.0401
open field	whole arena resting time, 20 min test	-46.473	20.283	-0.72378	0.104	0.0263
open field	whole arena time spent mobile, 20 min test	46.372	20.267	0.95711	0.105	0.0265
open field	whole arena time spent vertical, 20 min test	3.8648	8.6286	0.18840	0.861	0.656
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.77500	1.7614	-0.14715	0.861	0.663
startle / PPI	average baseline movement during background noise	2.6470	1.4096	1.4726	0.565	0.0690
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.11427	0.083507	0.93910	0.535	0.180
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.081578	0.080637	0.72603	0.664	0.319
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	1.2660	11.256	0.20530	0.994	0.911
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.2858	8.0666	0.68022	0.713	0.373
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	10.204	6.5043	0.91328	0.388	0.126
startle / PPI	average startle response to full pulse (120 dB)	-64.877	33.410	-0.93910	0.202	0.0605
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-61.479	33.336	-0.91328	0.229	0.0739
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-55.335	30.257	-0.86542	0.230	0.0762
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-46.023	25.247	-0.84322	0.241	0.0771
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.59342	1.3853	-0.39613	0.937	0.671
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.016667	1.2882	0.041345	0.998	0.990
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	2.2265	2.1752	0.78277	0.728	0.313
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.099249	0.13175	-0.88598	0.900	0.457
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.037702	0.088792	0.23283	0.882	0.674
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.18948	0.083065	1.2589	0.153	0.0289
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-67.524	33.510	-0.97228	0.183	0.0519
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-60.998	33.593	-0.90270	0.239	0.0782
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-55.507	30.170	-0.86746	0.227	0.0745
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-48.435	25.518	-0.86542	0.214	0.0662
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.032207	0.13921	-0.25277	0.973	0.818
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.055583	0.085776	0.34456	0.783	0.521
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.19683	0.082775	1.2226	0.137	0.0232
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-246.25	121.98	-0.98131	0.184	0.0515
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-247.58	120.88	-1.0206	0.168	0.0483
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-204.95	112.15	-0.87360	0.228	0.0764
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-190.40	96.153	-0.94128	0.191	0.0558
startle / PPI	maximum baseline movement during background noise	5.6128	3.0823	1.3582	0.539	0.0774
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.7869	12.077	0.62304	0.942	0.635
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	4.0490	8.1368	0.27453	0.839	0.622
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	13.842	7.2580	1.1305	0.273	0.0650
startle / PPI	maximum startle response to full pulse (120 dB)	-240.64	121.94	-0.95666	0.196	0.0566
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-250.43	120.30	-1.0206	0.160	0.0450
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-204.31	112.32	-0.86542	0.230	0.0777
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-186.28	95.405	-0.92827	0.198	0.0592
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.5183	3.9995	-0.94565	0.791	0.385
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.31958	2.9261	0.12150	0.991	0.914
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	6.1746	5.2194	0.85528	0.630	0.245

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.00
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.0
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.0
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	21.0 %	0.345
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	11.0 %	0.487
eye morphology	lens opacity	females	24.0 %	0.0719
eye morphology	lens opacity	males	61.0 %	0.00111
eye morphology	lens opacity	both	36.0 %	0.000525
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.0
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.00
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.0
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	12.0 %	0.00587
SHIRPA	tail curvature	males	12.0 %	0.00592
SHIRPA	tail curvature	both	12.0 %	0.0000488
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	23.0 %	0.00946
SHIRPA	tail elevation	both	11.0 %	0.0329
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Tnks1bp1^em1(IMPC)J -/- with genotype: